37 replies to this topic

[Harkijn]

Here is yet another very large prospective study confirming a link between glucosamine use and lower cancer rates:

https://www.frontier...022.947818/full

 

Quote:

'Conclusion: Habitual glucosamine use was significantly related to decreased overall cancer, kidney cancer, lung cancer, and rectum cancer mortality, based on data from the large-scale, nationwide, prospective UK Biobank cohort study.'

Unquote.

[Zarathrustra]

Interesting.

 

For me, glucosamine correlated with my becoming more cancerous. One of the reasons I self-track is that I found that what well may be true for some research, this latter is always about averages and may not apply to me. Not for the first time, I have found that indeed a research finding is at odds with my experience.

[Daniel Cooper]

Interesting.

 

For me, glucosamine correlated with my becoming more cancerous. One of the reasons I self-track is that I found that what well may be true for some research, this latter is always about averages and may not apply to me. Not for the first time, I have found that indeed a research finding is at odds with my experience.

 

So you got cancer while taking glucosamine?

 

 

[Zarathrustra]

Yes. I was taking it for years on and off.

 

More importantly, since that brush with death (2007), I have tracked my cancerousness with frequent markers as well as glucosamine intake and it is from this really that I can see the correlation - the two rise and fall together.

[ironfistx]

Interesting.

 

You are incorrect about my CRP being in mg/dL; it is in mg/L

 

I do not use established means of changing my various levels; I relay on my own correlations to determine whether and how to address any perceived change requirements.- 400+ item lifestyle variables.

 

I keep my iron levels on the low side, being convinced by the "The Mindspan Diet" book by Preston Ester that higher iron levels are probably an Alzheimer stimulant.

Do you mind if I ask what kind of glucosamine you used?  Seemingly there are different kinds, moreover after reading at novoslabs.com I'm questioning which kinds actually work, if any, for the purpose of longevity.  There is glucosamine sulfate potassium chloride, there is glucosamine sulfate sodium chloride, and there is glucosamine hydrochloride.  And apparently there is glucosamine hydrochloride potassium sulfate.

 

*Supposedly* the best kind Is crystalline glucosamine sulfate, which I believe is glucosamine sulfate sodium chloride.  This kind is hard to find.  That may be the kind used in the studies.  Where a study just say "Glucosmine Sulfate" that doesn't really help.

Edited by ironfistx, 26 December 2022 - 07:02 AM.

[Zarathrustra]

No, I do not mind at all; always happy to share.

 

I wasn't aware that there were different sorts, and which may be quite different in their reactions. Having said that, I am reluctant to add to my already 400+ variables and hence would need some convincing of there being meaningful differences between the different sorts before I'd track them separately.

 

I took a prepackaged set of supplements (Nutrashield) for years, which had the the following:

Glucosamine hydrochloride 500mg (Active ingredients: Glucosamine hydrochloride (from shellfish), eo-enzyme Ql0 Other ingredients: Soya oil beeswax Capsule shell Gelatin, glycerin, natural colours (titanium dioxide, plain  caramel, annatto) providing Glucosamine 415mg

 

And from 22 Aug 20 for a while: Transforme Glucoamine Sulphate 2KCl 1,500mg 365 tabs, Glucosamine Sulphate 2KCl 1,500mg, Providing Glucosamine Sulphate 1,131mg, of which Glucosamine 888mg.

 

My tracking shows a negative correlation with glucosamine for morning HRV PNN50 (so probably good), but a positive correlation with two cancer markers (so probably bad).

 

On body composition, taking glucosamine correlates positively with muscle and bone mass - and so probably good for those.

 

On balance, I've decided that glucosamine is not probably good for me.

[Florin]

A large study of new users of glucosamine suggests no effect on cancer incidence.

 

Glucosamine and cancer incidence in osteoarthritis: A prevalent new-user cohort design
https://doi.org/10.1002/acr.25399

 

Conclusions: In this large, real-world study of patients with osteoarthritis, designed to emulate a trial, treatment with glucosamine did not reduce the incidence of cancer. This finding reinforces that previous studies, not based on new users, were affected by selection bias. Our study does not support the use of glucosamine to prevent cancer in patients with osteoarthritis.

 

Edited by Florin, 12 July 2024 - 08:51 PM.

[Zarathrustra]

Whilst using research to inform my decisions on how to improve/change my lifestyle, it is always secondary to what I find from my own research on myself. Overall, it seems helpful.

 

  Glucosamine  100mg   Correlations   t <5%         CxBladder -0.0670   NMP22 -0.1008   CA19-9 -0.1199   CEA 0.0042   CRP -0.1506   AST/ALT     Neutro/Lymph -0.0464   Hb:PLT 0.1332   Basophil 0.0756   Eosinophils 0.1875   CRP:Albumin -0.1899   Blood