Hi Longecity,
Seeing as this forum is populated with some of the greatest minds in biohacking/physiology, I'd like your input.
Can you verify if this experiment has any probability of being effective?
The desired outcome is: Increasing rate of Vitamin A catabolism.
It's of use for people suffering from Hypervitaminosis A.
I would NOT like any input or questioning of whether it should be done at all.
There are people who suffer from Chronic HVA, and there are people who die from it.
But there's no known cure.
That's the applicability.
https://www.scienced...022347687801099
(Study where kids suffered from HVA, one of whom died.)
Check this blogpost and especially the comment section for more cases of people suffering from it:
https://www.healthex...icity/#comments
Here's my experiment for depleting it:
Retinoic acid is broken down primarily by Cyp26b1 and cyp26a1, which makes them the rate limiting enzymes in VA catabolism.
Pioglitazone is the strongest known inducer of this VA-catabolic enzyme, causing it to increase up to 54x.
That’s a 5400% increase in catabolic rate.
Here’s the study:
https://www.ncbi.nlm...les/PMC2812069/
And for some further support of this hypothesis, a study of cyp26b1 knockout animals: they quickly suffer from Hypervitaminosis A.
https://www.scienced...352187218300391
As this study points out, PPARy also controls Retinoic acid synthesis from Retinol, and Rosiglitazone (cousin of Pioglitazone) also induces Retinol dehydrogenase and Retinal dehydrogenase, which are the rate-limiting enzymes in Retinoic acid synthesis:
https://www.ncbi.nlm...les/PMC2118109/
The hypothesis I'd like feedback on then is:
Could Pioglitazone be used to Increase the rate at which Vitamin A is depleted?
The studies seem to indicate that the whole pathway of Retinol to RA conversion and subsequent breakdown is accelerated by Pioglitazone.
What are your thoughts?
Thanks everyone.
P.s.
I'm aware of the potential harm of Pioglitazone and Rosiglitazone.
Pioglitazone is the "safer" option but still carries side effects.
But the application is for people with incurable Chronic HVA.
Edited by chung_pao, 23 February 2019 - 06:43 PM.
