Hi, I am Yamu, I am very interested in anti-aging and have read a lot about this topic.I found that chamomile may help to delay aging.Chamomile can be a good gift, we can buy chamomile as a gift to friends who don't want to take drugs.
My self-introduction :https://www.longecit...na/#entry868085
Efficiency of Chamomile
Chamomile contains apigenin and quercetin, apigenin is an inhibitor of CD38, CD38 is one of the main cellular NADases in mammalian tissues and appears to regulate cellular levels of NAD in multiple tissues and cells.CD38 levels increase in tissues with age and correlate with NAD+ decline[1].Apigenin is an activitor of AMPK and SIRT1 as well as inhibitor of the NAD+ ase CD38,pharmacological inhibition of CD38 results in higher intracellular NAD(+) levels[2].Auercetin is an activitor of AMPK and SIRT1[3], Auercetin can also inhibit CD38(maybe AMPK activitors have some mechanism that can inhibit CD38).
Potential Efficiency of Chamomile:
1、Activate SIRT1 can reduced oxidative stress by FOXO3a deacetylation[4].
2、Prevent neurodegenerative disorders( Alzheimer’s, Parkinson’s Huntington’s and so on) of ageing. Promote NAD+, activate AMPK and SiIR1 can prevent and cure neurodegenerative disorders[5].
3、Prevent cancer.NAD+ decline is a cause of thymus atrophy[6], thymus atrophy rising cancer incidence[7]. NAD+ decline reduces the ability of DNA repair.DNA damage is a cause of cancer too.[9]What's more, apigenin can prevent cancer by activate PI3K/Akt/mTOR[8].
4、Anti-aging. NAD+ and sirtuins decline can cause aging and related diseases.[9]
5、Improve the quality of sleep. SIRT1 regulates biological clock,activate SIRT1 can improve the quality of sleep.
The anti-aging material that chamomile contains is not too much,if you want to reverse aging, you should take more anti-aging dietary supplement or drugs.
[1]CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.
Camacho-Pereira J, Tarragó MG, Chini CCS, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN.
Cell Metab. 2016 Jun 14;23(6):1127-1139. doi: 10.1016/j.cmet.2016.05.006.
[2]Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.
Escande C, Nin V, Price NL, Capellini V, Gomes AP, Barbosa MT, O'Neil L, White TA, Sinclair DA, Chini EN.
Diabetes. 2013 Apr;62(4):1084-93. doi: 10.2337/db12-1139. Epub 2012 Nov 19.
[3]Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model.
Feng K, Chen Z, Pengcheng L, Zhang S, Wang X.
J Cell Physiol. 2019 Mar 10. doi: 10.1002/jcp.28452.
[4]Overexpression of Sirt1 in mesenchymal stem cells protects against bone loss in mice by FOXO3a deacetylation and oxidative stress inhibition.
Sun W, Qiao W, Zhou B, Hu Z, Yan Q, Wu J, Wang R, Zhang Q, Miao D.
Metabolism. 2018 Nov;88:61-71. doi: 10.1016/j.metabol.2018.06.006. Epub 2018 Jul 3.
[5]Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing.
Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ.
Nat Rev Drug Discov. 2018 Sep;17(9):660-688. doi: 10.1038/nrd.2018.109. Epub 2018 Aug 17. Review.
[6]NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion.
Diani-Moore S, Shoots J, Singh R, Zuk JB, Rifkind AB.
Sci Rep. 2017 May 23;7(1):2268. doi: 10.1038/s41598-017-02332-9.
[7]Thymic involution and rising disease incidence with age.
Palmer S, Albergante L, Blackburn CC, Newman TJ.
[8]Targeting the PI3K/Akt/mTOR axis by apigenin for cancer prevention
Xin Tong, Jill Pelling
Anticancer Agents Med Chem. Author manuscript; available in PMC 2014 Sep 1.
Published in final edited form as: Anticancer Agents Med Chem. 2013 Sep; 13(7): 971–978.
[9]NAD+ and Sirtuins in Aging and Disease
Shin-ichiro Imai, Leonard Guarente
Trends Cell Biol. 2014 Aug; 24(8): 464–471.
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1883-1888. doi: 10.1073/pnas.1714478115. Epub 2018 Feb 5.
