Hello, i have not menaged to find any strong stimulant without tolerance. the only good target that i have found is adenosine 2a.
a2a antagonists are being tested as new parkinson treatment [1] and pretty much any parkinson drugs is a possible stimulant for healthy (l-dopa, mao inhibitors ecc.)
caffeine is a a2a antagonist, but its short-term effect and lack of selectivity (a1 antagonism cause tolernace overtime [2]) makes it pretty much useless for me.
teacrine seemed good, but it has no real stimulation and ruins my sleep (max 4-5 h while i take it in the morning)
[1] https://www.ncbi.nlm...les/PMC2583202/
[2]https://www.scienced...014299900006828
studies: https://sci-hub.tw/1...1910-012-0279-2
is there someone who would like to do a small-group buy it buy any selective a2a antagonist??
the price should be low
