Here is an interesting article about the relatiosnhip of TGF-β to Skin Aging
https://www.fightagi...-in-aging-skin/
What is really interesting, however, is the post at the bottom (very first comment), which reads as follows:
Now that we know TGF-β causes sagging and wrinkles by preventing formation of dermal fat, should we toss all of our skin lotions containing growth factors? As for the systemic problem, balance should be the goal but people over 50 probably have too much. The diabetes drug pioglitazone has been shown to help increase dermal fat in those who have lost it due to HIV drugs. A couple studies show a healthy increase in dermal fat with a decrease in viscarel fat in healthy people taking it low dose. This is interesting as it relates to the above study because ppar-gamma reduces TGF-β expression. Pioglitazone is the safest drug that can meaningfully increase ppar-gamma. Perhaps the anti-aging appearance effects of low dose ( 7.5 mg per day) Pioglitazone are related to TGF-β suppression via ppar-gamma activation.
I have actually located some studies that confirm Pioglitazone's ability to increase subcutaneous fat, Example:
https://journals.plo...al.pone.0109134
However, I am not sure one can really conclude, based on this, that such an effect would make one look younger..
Any thoughts?
