I'm interested in this new drug thats supposed to decrease the amount you eat at meals but its not available yet and i'm sure its not going to be cheap.
https://www.myplenit...m/#the-benefits
It seems like a pretty simple formula of citric acid and cellulose cross linked.
PLENITY is administered in the form of capsules taken with water before lunch and dinner. PLENITY is made by cross-linking two naturally-derived building blocks – cellulose and citric acid – to create a three-dimensional hydrogel matrix.
I found this article and it seems the process of cross linking these substances is pretty straight forward.
http://www.ijpsonlin...ug-delivery.pdf
Preparation of citric acid crosslinked TG-based hydrogel films: The citric acid crosslinked hydrogel films of TGCMC were prepared by esterification-crosslinking mechanism, as reported elsewhere[10]. Two percent w/v aqueous solutions containing TG, CMC and citric acid were prepared using a mechanical stirrer (RQG126D, Remi, India), at room temperature (Table 1). The solutions were kept overnight to remove the entrapped air bubbles. The aqueous solutions (50 ml) were casted into 9 cm diameter Petri dishes and Parameter Batch code B1 B2 B3 C1 D1 TG:CMC* 1:1 2:1 3:1 1:1 1:1 Citric acid (%) 10 10 10 15 20 Curing temperature (°) 140 140 140 140 140 Curing time (min) 5 5 5 5 5 TABLE 1: CMC AND TG HYDROGEL FILMS TG- tamarind gum; CMC- carboxymethyl cellulose (sodium salt); *total polymer concentration equivalent to 2 % w/v www.ijpsonline.com July-August 2018 Indian Journal of Pharmaceutical Sciences 659 dried at 50° for 24 h. The resulting films were cured at 140° for 5 min. The curing temperature and curing time was sufficient to achieve crosslinking. The cured hydrogel films were washed with distilled water and isopropyl alcohol for 1 h in order to remove untreated entities. Then, the hydrogel films were dried in a hot air oven at 50° for 24 h and stored in a desiccator until use. The parameters such as concentrations of TG, CMC, citric acid and curing time were varied individually to study their effect on hydrogel properties[31].
Does anyone have any experience with this type of process and how difficult it would be to produce?
Thanks
David
