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Supplemental pyruvate increases NAD via NAMPT and activates SIRT1

Started by p75213 , Oct 16 2019 09:15 AM
nad+ mef2c nampt

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#1 p75213

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Posted 16 October 2019 - 09:15 AM


"Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1."

Nucleic Acids Res. 2019 Oct 10. pii: gkz864. doi: 10.1093/nar/gkz864.
"Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway."

https://www.ncbi.nlm...pubmed/31598701
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#2 orion22

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Posted 16 October 2019 - 12:05 PM

by how much


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