7 replies to this topic

[p75213]

I'm thinking of getting a kg of NMN powder from a manufacturer in China and having it independently tested by a lab. My question is what sort of a test should they do if I wish to confirm the COA supplied by the manufacturer?

Also how long will NMN powder last if stored in the fridge or freezer? 

[Fafner55]

A recent human trial failed to show benefit from NMN supplementation.

 

"Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men" (2019) https://www.jstage.j...9-0313/_article

[Fredrik]

A recent human trial failed to show benefit from NMN supplementation.

 

"Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men" (2019) https://www.jstage.j...9-0313/_article

 

You are misrepresenting or misunderstanding the trial.

 

How can a study fail to show benefit when it was not designed to do so?

 

The study you posted was a one-time single dose safety study of oral NMN. It was ONE PILL. It didn´t look at long-term efficacy of anything. Those studies are yet to be published.

 

"A single-arm non-randomized intervention was conducted by single oral administration of 100, 250, and 500 mg NMN."

 

 

They only looked at SAFETY:

 

"The single oral administration of NMN was safe and effectively metabolized in healthy men without causing any significant deleterious effects."

 

 

Edited by Fredrik, 13 November 2019 - 12:11 PM.

[Smith]

According to Dr. Sinclair's recent interview, NMN must be refrigerated otherwise it will quickly break down. He doesn't say how long it will last when cooled, but presumably a long time since he claims to have a bunch in his basement.

 

Futhermore, he states there is probably a threshold dose one much go over before it has any effect due to the body's clearance mechanisms.  Some studies showed effectiveness of NMN at 200mg/kg in mice.  The minimum HED could be somewhere around 1000-1250mg / day.

Edited by Smith, 13 November 2019 - 07:36 PM.

[Fafner55]

A recent human trial failed to show benefit from NMN supplementation.

 

"Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men" (2019) https://www.jstage.j...9-0313/_article

 

I retract this comment and regret posting it hastily without careful reading.

[PAMPAGUY]

Dr. Sinclair in his latest video, stated that he takes 1 gram NMN + 1 gram Resveratrol as a NMN booster daily.   The Jap study and most others do not administer high enough doses  You need a high dose in order to get the NAD precursor out of the liver and into the rest of the body.   NMN discussion starts around 50 min. into video.

 

https://www.foundmyf...AImeThKHD2ChsII

 

 

[malbecman]

 You would want confirmation of purity by HPLC as well as identity by LC-MS.    It would probably be good to get a heavy metal screen as well.

[LawrenceW]

At a minimum I would get this:

 

https://alivebynatur...Summit-Cert.jpg