I've been going through Wikipedia hoping to find a sedating antihistamine without negative effects on cognition and memory. Unfortunately there are many incomplete articles. Any suggestions or experiences?
Central Anti-histamines without strong anti-cholinergic effects?
Started by
BioInfinite
, Nov 16 2019 05:40 AM
antihistamines anticholinergic sedative cognition memory
1 reply to this topic
#1
Posted 16 November 2019 - 05:40 AM
#2
Posted 02 December 2019 - 09:07 PM
You have for all intents and purposes described hydroxyzine (Atarax/Vistaril),
Hydroxyzine has a low affinity for muscarinic acetylcholine receptors and is noted to cause minimal effect on memory and cognition compared to other antihistamines but will cause somnolence. It is prescribed as a sleep aid and anxiolytic.
Wikipedia - Hydroxyzine
I'm unsure of how quickly tolerance will build with daily use but I would be surprised if it didn't to some extent.
Also tagged with one or more of these keywords: antihistamines, anticholinergic, sedative, cognition, memory
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