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[BioInfinite]

I've been going through Wikipedia hoping to find a sedating antihistamine without negative effects on cognition and memory. Unfortunately there are many incomplete articles. Any suggestions or experiences?

[Daniel Cooper]

You have for all intents and purposes described hydroxyzine (Atarax/Vistaril),
 
Hydroxyzine has a low affinity for muscarinic acetylcholine receptors and is noted to cause minimal effect on memory and cognition compared to other antihistamines but will cause somnolence.  It is prescribed as a sleep aid and anxiolytic. 
 
Wikipedia - Hydroxyzine

 

I'm unsure of how quickly tolerance will build with daily use but I would be surprised if it didn't to some extent.