6 replies to this topic

[peoplepleaser101]

METHODS AND RESULTS:

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Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max)) was increased to 1544% with the addition of piperine.

 

CONCLUSION:

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Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.

 

- Source: https://www.ncbi.nlm...pubmed/21714124

 

This is pretty old stuff though, so I guess most of you already know this.

Edited by peoplepleaser101, 17 November 2019 - 02:40 PM.

[Castiel]

There is a claim that resveratrol processed by the liver is converted back into resveratrol within cells.   So not sure, depending if that claim is true or not, would be how beneficial inhibiting liver processing would be.   Fat increases the absorption of resveratrol into the system by 500%, if I'm not mistaken.   Might not necessarily matter that the liver processes it, if the claim of it being converted back in tissues is true.  

 

What might be necessary is to increase absorption even more than 500%

[Hip]

It's the AUC that I think is more important here; the AUC is in effect the average blood concentration over time after a dose is taken. The peak concentration (Cmax) only lasts for a relatively short time.

 

Piperine approximately doubles the AUC according to the above study.

 

 

Note that too high a blood concentration of resveratrol may be toxic for the kidneys: the Sirtris Pharmaceuticals trial of a 5000 mg resveratrol drug called SRT501 led to some of those taking it getting kidney failure. Ref: here.

[Castiel]

References

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence.

https://www.ncbi.nlm...pubmed/24089405

 

As for the fat resveratrol comment, I think David Sinclair said so in a few of the interviews he gave about his recent book.  He said that it boosted absorption by like 5x, if I recall correctly.

[peoplepleaser101]

What's your guys take on Resveratrol decreasing brain volum in Alzheimer patients.

This study: https://www.ncbi.nlm...pubmed/26362286

 

RESULTS:

 

Resveratrol and its major metabolites were measurable in plasma and CSF. The most common adverse events were nausea, diarrhea, and weight loss. CSF Aβ40 and plasma Aβ40 levels declined more in the placebo group than the resveratrol-treated group, resulting in a significant difference at week 52. Brain volume loss was increased by resveratrol treatment compared to placebo.

 

 

[Castiel]

 

What's your guys take on Resveratrol decreasing brain volum in Alzheimer patients.

This study: https://www.ncbi.nlm...pubmed/26362286

 

RESULTS:

 

would need to investigate.  It could be that it decreased inflammation which decreased volume but improved health.

[peoplepleaser101]

would need to investigate.  It could be that it decreased inflammation which decreased volume but improved health.

That seems like a possible explanation, however, not even the researchers that did the study had an theory, so who knows :/