12 replies to this topic

[Believer]

A month ago my 75 year old father had a stroke, brain bleeding followed by multiple blood clots.

His left side, arm, hand, leg and feet is practically immovable but not numb.

He has difficulty swallowing and chewing food due to some oral reflex being dysfunctional, typical for stroke patients.

 

The objective is to regain the ability for him to walk and talk properly. His cognitive functions are intact.

 

We've tried:

(1) Nicotinic acid (niacin, 0.5-1.5 gram), it helped and helps but only slightly.

(2) Taurine 500mg, messes his sleep up but he claims it benefits him mentally.

(3) Cerebrolysin 5-25ml, once the next day he had better vision and when we did 25ml he became fatigued the next day. Total waste of money.

(4) Semax (peptogen.ru ,not sure if acetylated), absolutely worthless and overpriced, no benefit or effect at ALL. I should probably try reconstituting the acetylated powder form.

(5) DHEA timed release 50mg, helps his sleep quality. Supposed to bind to NGF receptors TrkA but doesn't seem to benefit him in that sense.

(6) IGF1-LR3 1mg intranasal, doesn't seem to have any effect at all.

(7) BPC-157 5mg intranasal, seems to alleviate his asthma symptoms.

(8) TB-500 5mg intranasal, not sure if this or BPC alleviated the asthma symptoms.

 

I wish to try:

(9) Taltirelin - 100mg, intranasal.

(10) PEG MGF - 5mg, intranasal. It's claimed to have potential growth stimulating effects in rat brain???

(11) P-21 - 50mg, intranasal.

(12) N- Acetyl Semax Amidate 30m, intranasal. The shit I bought was probably not acetylated, might as well try again.

(13) GHK-CU 100-200mg intranasal, is supposed to stimulate nerve growth factor but not sure if it also does this in the brain. Might as well try.

(14) Ladostigil, is claimed to be neurogenic.

(15) Fabomotizole (Afobazole), is supposed to increase neurotrophins. Looks promising.

 

Please advice me on supplements/drugs/peptides whatever might help

[Believer]

I wish to try:

(16) Palmitoyl Tetrapeptide-7 (Rigin) is supposed to have nerve regenerating effects so will try that as well.

(17) GLP-1 (Glucagon Like Peptide -1) supposedly has neuroregenerative properties, increasing neurite outgrowth (but doesn't seem by much) so I may give it a try as well.

[Believer]

I wish to try:

(18) L1L4, a fragment of nerve growth factor which is substantially cheaper to produce than nerve growth factor itself but has >60% of the binding potency of real recombinant human nerve growth factor.

"H-CTDIKGKCTGACDGKQC-OH" is the amino acid sequence of L1L4 although I am not sure if this is entirely correct.

 

 

https://www.jneurosc...tent/28/11/2698

https://www.research...ic_Pain_in_Rats

https://www.ncbi.nlm...pubmed/18337399

[Daniel Cooper]

I replied in another thread.  I would go with 1% Semax if you can afford it.  

 

https://cosmicnootro.../products/semax

 

You want the 1% (pulldown menu).  

[Believer]

I replied in another thread.  I would go with 1% Semax if you can afford it.  

 

https://cosmicnootro.../products/semax

 

You want the 1% (pulldown menu).  

 

Already tried it - no effect whatsoever.

If you read number (12), I have ordered a large quantity of semax (much more than those 1% bottles contain). We will see

 

[Daniel Cooper]

When did your father have the stroke?

 

These things take a lot of time to recover from.  Nerves and brain tissue regenerate *very* slowly.  What these peptides might do for you is make the recovery somewhat faster and hopefully wind up at a better endpoint.  But nothing is going to improve the recovery time from 6-12 months to a month or so.

 

BTW - sorry that your father has had to go through this.

 

 

ETA:  I see it was a month ago.  Yeah, nothing is going to make a dramatic improvement at the one month mark.  These strategies are to pull in a recovery so that a 1 year recovery might be compressed into 9 months and have an endpoint that is more functional at that point.  Even if we had stem cell therapy up and running for strokes, you wouldn't see anything miraculous at the 1 month mark.

 

 

Edited by Daniel Cooper, 05 December 2019 - 07:48 PM.

[ambivalent]

If you can find it there is a post from niner buried in the c60 thread where he gave his mother in law a bottle of c60oo while in hospital recovering from a stroke and stated her to have made a full recovery. This study appeared to supported this approach, though timeliness obviously matters, so it is referenced somewhat for information purposes.

 

http://news.rice.edu...-flow-in-brain/

 

I would have thought fasting would be of benefit. Quickly found this:

 

https://spinalflowyo...troke-recovery/

 

This is of limited evidence obviously, since we'd prefer to know the benefit without pre-stroke fasting. There was an interesting comment posted though of someone experiencing tingling in the affected after a 24 hour fast.

 

Aside: I recall reading over a decade ago of a method of watching videos of yourself moving the unaffected side of the body, stimulates the activity in the brain associated with injury and aided recovery (when we wish to indicate to someone they have sauce on their left cheek, we instinctively point to our right one).

 

What about other NAD precursors other than Niacin?

 

https://svn.bmj.com/content/4/2/83

 

Good luck

 

Also I'd research meditation too.

[Believer]

We've now also tried:

(9) Taltirelin intranasal, so far no discernible effects. The dosage was even quite high.

(10) PEG MGF intranasal. No effect whatsoever intranasal

(11) P-21 intranasal, this is the only thing we actually felt. Instantly I feel a sharpness in my vision, improvement in my sense of smell and increase in mental clarity. I love it, will order again in the future.

(12) N- Acetyl Semax Amidate intranasal. Absolutely no effect. This time I even megadosed it but still.. What a waste of money.

[Daniel Cooper]

Again, I think you're expecting noticeable results in a few weeks.  That's just not realistic.  Your father has brain damage due to ischemia/reperfusion.  Brain tissue has died or been damaged to the point it is not functional.  In order to heal, the brain must regenerate what it can (a veeeerry slow process) or shift certain functions to other undamaged areas .

 

What is the doctor telling you in terms of recovery period?  What are your expectations that any of these treatments might accomplish?  I'm suggesting that at best, any of the treatments you have access to might improve the recovery time the doctor is quoting by 10 - 20% and might result in improved functionality out at the 1 year mark.  

 

I don't think there's anything on the planet today that would show a dramatic improvement to a serious brain injury in a couple of weeks.  You're talking Star Trek level technology there.

 

 

 

 

[Believer]

Again, I think you're expecting noticeable results in a few weeks.  That's just not realistic.  Your father has brain damage due to ischemia/reperfusion.  Brain tissue has died or been damaged to the point it is not functional.  In order to heal, the brain must regenerate what it can (a veeeerry slow process) or shift certain functions to other undamaged areas .

 

What is the doctor telling you in terms of recovery period?  What are your expectations that any of these treatments might accomplish?  I'm suggesting that at best, any of the treatments you have access to might improve the recovery time the doctor is quoting by 10 - 20% and might result in improved functionality out at the 1 year mark.  

 

I don't think there's anything on the planet today that would show a dramatic improvement to a serious brain injury in a couple of weeks.  You're talking Star Trek level technology there.

I tested the supplements on myself to see which did what, because I was going to mix them together in one big 30ml nasalspray and I wanted to know their effects individually.

Contrary to popular belief, the effects of neurotrophins are immediate, felt and seen within milliseconds of administration. This doesn't mean that they cure brain damage instantly but it means they grow or affect the brain immediately and the higher the dosage the more the effect.

If Semax had increased BDNF or done anything at all then it should immediately be felt. However semax even in large dosages did absolutely nothing. Maybe it was bunk or I have so weird mutation that makes it not work. Nicotinic acid also increases BDNF and it can definitely be felt instantly.

My father is taking the nasalspray every day, twice a day. I don't expect much but it was just to test anyway.

 

Right now I am waiting for the L1L4 nerve growth factor fragment 10mg I paid 400 dollars for. Read my earlier comment about L1L4. It is being synthesized in China and takes 3 weeks to synthesize and 1-2 weeks for transportation. We are at week 2 now. There's also a package with GLP-1 on the way from China which should be here next week. The package also contains 50mg BPC-157 because he asked for more of it, he feels it helps his asthma and airway inflammation. I also wanted to see if the BPC could perhaps cure my penile damage scar tissue--yes I know it's weird to mention in the same paragraph but in my early teens i damage my penis from chronic masturbation and since then it has only gotten more deformed and damage. There's nerve damage, scar tissue and inflammation.

 

edit whoops I forgot to add that the doctor does not expect his inability to move his left side to improve. The doctor thinks it's permanent damage. But "permanent" has many times proven to be not true in regards to medical problems.

Edited by Believer, 17 December 2019 - 06:20 PM.

[Daniel Cooper]

You're making a logical fallacy.  You're assuming that a compound that will help a damaged brain repair itself, i.e. return to baseline or some approximation of it, will take your undamaged brain and improve it beyond baseline.  There's no reason that should be the case and many that it should not.  

 

 

 

 

[ironfistx]

wobenzym?

 

http://www.mnwelldir...dio/cardio3.htm

[Believer]

Now we've tried

(18) I had L1L4 (nerve growth factor fragment) synthesized by a Chinese manufacturing company doing peptide synthesis.Took 3 weeks and cost a little over 400 dollars for the peptide, at >95% purity and 10mg.

 

I tried intranasal administration both with only water and only pure DMSO, and did not really feel anything typically associated with nerve growth factor except maybe a bit sharper vision for a short while but it was so mild so as to probably be placebo. Both myself and my father experienced the vision effect very mildly.

 

I now have tried injecting small microgram quantities subq in an acetic acid 0.6% solution.

Now I am experiencing very mild neuropathy in my hands and feet. No improvement of my senses as nerve growth factor is known to do so definitely, 100% this is not a nerve growth factor fragment, it does not have the pharmacology of NGF or L1L4. Something must've went wrong in the manufacturing process. Although the company claims HPLC shows 99% purity and that it definitely is what I ordered.

 

https://www.jneurosc...tent/28/11/2698