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S O U R C E : Geroprotectors.org
259 Experiments data in the database.
2408 references for corresponding compounds.
13 model organisms associated with experiments.
Welcome to Geroprotectors.org, the curated database of geroprotectors!
The risk for many chronic diseases increases as we age. These diseases include cardiovascular and metabolic syndrome-related problems such as type II diabetes, atherosclerosis, hypertension, myocardial infarction and stroke, as well as cancer and neurodegenerative diseases. Studies show that some agents which extend the lifespan in animal models may also be effective in humans. Geroscience, which aims to conserve the healthy state of the body, may therefore become a key concept in biomedicine in the near future, as chemicals become available which slow ageing and prevent or delay the onset of age-related diseases.
A “geroprotector” is any intervention that aims to increase longevity, or that reduces, delays or impedes the onset of age-related pathologies by hampering aging-related processes, repairing damage or modulating stress resistance.
The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others). We gathered data about more than 200 chemicals promoting longevity, including compounds approved for human use. This database integrates information about lifespan-increasing experiments and related compounds, suppression of aging mechanisms, activation of longevity mechanisms and age-related diseases obtained from research papers and databases.
Geroprotectors.org is intended as a tool for accelerating the process of identifying geroprotectors from a variety of existing substances through pharmacological modeling and biostatistical analysis to reveal new substances with geroprotective effects.
Citation
For the purposes of citation referring the URL might be enough in some cases (e.g., teaching and websites), for scientific publications we ask that you cite Geroprotectors.Org using:
Moskalev A et al. Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease. Aging (Albany NY). 2015
Contributors
We thank the following for their contributions to the project, either technically or academically.
Alexey Moskalev - Project leader
Alex Zhavoronkov - Project leader
Vladislav Bogomolov - Developer
Alexei Scerbacov - Developer, Xpansa Global
Roman Gurinovich - Technical Management, Xpansa Global
Elizaveta Chernyagina - Compilation of data for the database
Mikhail Shaposhnikov - Compilation of data for the database
Vasily Tsvetkov - Compilation of data for the database
Evgeny Bronovitsky - Compilation of data for the database
Alex Aliper - Compilation of data for the database
Arie Budovsky - Compilation of data for the database
Diogo Barardo - Compilation of data for the database
Harikrishnan Thoppil - Compilation of data for the database
João Pedro de Magalhães - Testing and constructive criticism
Vadim Fraifeld - Testing and constructive criticism
Andrew Garazha - Testing and constructive criticism
Leslie C. Jellen - Testing and constructive criticism
Brian Kennedy - Testing and constructive criticism
Polina Mamoshina - Testing and constructive criticism
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Edited by Engadin, 04 December 2019 - 10:46 AM.
