14 replies to this topic

[Lady4T]

Being a female of "a certain age," muscle and bone loss is a concern. After coming across a few studies, I have become interested in taking oxytocin.

Is anyone here taking it for its positive effect on muscle and/or bone?  I would be very interested in your experience, and will help me decide if it would be the right thing for me. 

 

An easy-read article:

 

Trust hormone’ oxytocin helps old muscle work like new, study finds

https://news.berkele...e-regeneration/

 

 

And here are some studies:

 

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.
https://www.ncbi.nlm...pubmed/24915299

 

Oxytocin and bone
https://www.ncbi.nlm...pubmed/25209411

Oxytocin reverses osteoporosis in a sex-dependent manner.
https://www.ncbi.nlm...pt=AbstractPlus

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.  
https://www.ncbi.nlm...pubmed/31422380




 

Edited by Lady4T, 21 December 2019 - 12:34 PM.

[Oakman]

I'm a male of a certain age.. etc., etc. I'd love to use this molecule, it's been discussed before, but the issues of $$, availability, and safety has kept me from it. So I agree, thoughts from anyone?.

[xEva]

vet versions, for injection, used to be readily available in the US, for little $ not that long ago (~7 years?). But with each passing year all meds become more and more expensive and difficult to obtain.

 

Injectable oxitocin is wildly used in delivery (both human and animal). 

 

[Lady4T]

xEva, Do you know where it could be obtained?

So far, I've learned that the commonly available nasal sprays might not be useful for this purpose, so it would need to be an injectable. I've been looking around the internet, and found a couple of sites, but it seems that a prescription is needed? Also, not sure what exactly would be the correct product.

 

Here's one from a vet supply:  https://www.valleyve...92-00B0D0204AE5

From the description:  Purified Oxytocic Principle. Each ml of Oxytocin Injection contains 20 USP units oxytocin. Administer by SQ, IM or IV route.

 

This one comes in a powder:  https://nootropicsou...tides/oxytocin/

From the description: Lyophilized Powder

 

Which would be the correct product?

 

Can someone suggest a reputable source?

Edited by Lady4T, 22 December 2019 - 03:23 AM.

[Lady4T]

I also found this:  Oxytocin 10mg

https://www.peptides...m/oxytocin-10mg

I think it's a powder, but the page doesn't specify.

[Oakman]

I also found this:  Oxytocin 10mg

https://www.peptides...m/oxytocin-10mg

I think it's a powder, but the page doesn't specify.

 

Love this site, first they say never to use this except in vitro, then it is illegal to ingest, bla, bla. The rest of the listing is how many wonderful things it does when used in people. Lame.

[Believer]

I'm a male of a certain age.. etc., etc. I'd love to use this molecule, it's been discussed before, but the issues of $$, availability, and safety has kept me from it. So I agree, thoughts from anyone?.

It's dirt cheap on Alibaba. 5-10 months supply for only as little as 25-30 dollars (not including shipping). I am buying it from there myself.

I don't believe the nonsense about purity concerns.

 

[Believer]

What about dosing protocols? Is it necessary to take it long-term or continuously?

[adamh]

The spray does work I tried it before going to a social meeting and everybody reacted more positively to me. Not subjective, lots of things were different. I was different too, I felt differently, more positive etc which no doubt influenced others but it seemed like it was working on them too. A spray in each nostril

 

Another time I used one small spray and it did not seem to do a whole lot. It can also intensify negative experiences and make you dislike people outside your group so its not all love and cuddles.

 

The spray I got also had rose oil in it which has a somewhat similar effect, got it on ebay. Bottle said 10 iu per spray. Now that I'm learning all the other good things it does I will probably use it more often. It wasn't expensive $22 for a bottle of 240 sprays. Or so they say but it really does not take much

 

I have ordered from alibaba, read the reviews carefully. They are tricky to say the least and often won't honor promises but there are good vendors and I got what I ordered each time except one that customs got.

 

Just don't expect something miraculous from oxy, a positive situation involving people can get better. Don't use it when you will be negotiating a business deal, it makes you more likely to bargain weakly out of empathy maybe. Its subtle but can make a big difference. Great for going out with the gang, perhaps good for a new date unless it ends badly then you feel worse. Going some place you do not feel 100% safe is not a good time for it. 

[Lady4T]

What about dosing protocols? Is it necessary to take it long-term or continuously?

 

Yes, of course the dosage is important. I'm still looking into this.

It would be great if someone here can chime in with their experience, or point us in the right direction.
 

[Rocket]

ThThought a lot about buying oxy over the years. I don't see much about it from users if anything. I personally look to things that keep the body from entering into catabolism which seems to be observationally the overriding theme of becoming old and frail.

For muscle that the op asks about, that is about a couple of major things: activating the androgen receptors, nutrition, exercise, and stem cells.

Edited by Rocket, 30 December 2019 - 01:47 AM.

[Lady4T]

I've been looking around for the past couple of days, but can't find articles or users post recounting their experiences using it to benefit muscles. Almost everything out there is about using it as a mood/behavior modifier.

Has anyone seen articles or posts from people using it to benefit muscles?

[VP.]

This Study:

The study focuses on two of the key molecules that influence the ability of stem cells to function and regenerate tissues: TGF-β1, which increases during aging, and oxytocin, which falls during aging. Using a pharmacological approach, they were able to reduce TGF-β1 levels and increase oxytocin, spurring rejuvenation and leading to significantly increased neurogenesis, a reduction of neuro-inflammation, increased cognitive performance, and rejuvenation of the liver and muscle in aged mice.

https://www.leafscie...ing-aged-blood/

 

Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity.

https://www.ncbi.nlm...les/PMC3813596/

 

Discussion on the Age Reversal forums: https://forum.age-re...en-tea-extracts

I'm in the process of making my own yogurt. 

[Lady4T]

From what I've researched, oxytocin is dosed in micrograms, not milligrams.

Here's a blurb from Wikipedia: 

"Oxytocin has a molecular mass of 1007 Da,, and one international unit (IU) of oxytocin is the equivalent of 1.68 μg of pure peptide."

 

The usual intranasal doses range from about 12 to 40 IUs.  So that would be about 20 to 67 micrograms. And I have found a couple of studies that used 10 IUs intravenous which would be about 17 micrograms.

[Lady4T]

One more data point:

 

"By convention, for the purpose of labelling oxytocin preparations, 1 mg of oxytocin peptide (C43H66N12O12S2) is equivalent to 600 IU of biological activity."

 

Source: Oxytocin --  World Health Organization (WHO)

https://www.who.int/...FINALJune10.pdf