11 replies to this topic

[sedentary]

i didnt know this about theaflavins but then i read this article; https://www.lifeexte...senescent-cells

so whats the deal with theaflavins. i know lifeextension usually exaggerates so they sell more products but the article does have good points. do you think theaflavins can fall into the senolytic category??

[kench]

I am using the LEF senolytic product, but I don't have much to report on as of now.

[Iporuru]

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

 

Highlights

• The lncRNA Hnscr is highly expressed in htNSCs of young mice but decreases during aging
• Hnscr depletion promotes the senescence of htNSCs and aging-like phenotypes
• Hnscr attenuates htNSC senescence by binding to YB-1 to prevent its degradation
• Theaflavin 3-gallate mimics Hnscr and ameliorates aging-related physiological disorders

Summary

Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, we report that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. We show that depletion of Hnscr is sufficient to drive the senescence of htNSCs and aging-like phenotypes in mice. Mechanistically, Hnscr binds to Y-box protein 1 (YB-1) to prevent its degradation and thus the attenuation of transcription of the senescence marker gene p16 ^INK4A. Through molecular docking, we discovered that a naturally occurring small compound, theaflavin 3-gallate, can mimic the activity of Hnscr. Treatment of middle-aged mice with theaflavin 3-gallate reduced the senescence of htNSCs while improving aging-associated pathology. These results point to a mediator of the aging process and one that can be pharmacologically targeted to improve aging-related outcomes.

 

Edited by Iporuru, 12 February 2020 - 06:14 AM.

[johnross47]

I treat myself with this stuff every day; usually about a litre of tea.

[sedentary]

a liter of water might be fine, but tea... i even know some people having that much coffee too. not sure its good for you long term

[johnross47]

I've been drinking tea since I was a child, like many people in the UK and I'm 73 now. I've never seen anything that made it look at all dangerous or harmful.

[sedentary]

oh wow so you probably consumed a lot of theaflavins in your life. i mean, what, like 60 years regularly perhaps? tea also contains quercetin. so i guess you should be experiencing senescence. can you feel it or see it somehow? probably take a test, like one of those telemores DNA tests

[johnross47]

I probably was introduced to tea by the time I was about 7 or 8, but being Scottish, it was drunk with quite a bit of milk, which would soak up the oxalic acid component. I take a lot less milk now, but still some.

[aribadabar]

Correct, adding milk to tea negates its beneficial properties.

[johnross47]

Interesting...I usually drink green tea neat as they say, and black tea with a small amount of milk ....I must measure how much. I could probably learn to drink it black, but then of course there would be the oxalic acid issue.??????

[sedentary]

Correct, adding milk to tea negates its beneficial properties.

 

any chance on figuring out which type of black teas contain what amount of theaflavins?

[johnross47]

http://seanol.com.br...e/artigos/8.pdf