3083 replies to this topic

[lancebr]

Here is a doctor in Dominican Republic talking about the use of Ivermectin with Azithromycin and seeing a 99% cure rate in 8 to 10 days.

 

https://www.trialsit...stage-covid-19/

Edited by lancebr, 01 July 2020 - 02:43 PM.

[kurdishfella]

I can't believe I'm still alive. I'm pretty sure I had and have covid-19 multiple times now. First In january 2020 which lasted three months then came back in march and still have it. Whole family has it. I was pretty much sure that I was gonna be dead soon. Maybe it will come soon.

Edited by kurdishfella, 02 July 2020 - 07:13 AM.

[gamesguru]

I can't believe I'm still alive. I'm pretty sure I had and have covid-19 multiple times now. First In january 2020 which lasted three months then came back in march and still have it. Whole family has it. I was pretty much sure that I was gonna be dead soon. Maybe it will come soon.

 

Sorry to burst your bubble, but likely just a bad flu.  Under 10,000 active cases in January in the USA means your chances of having it then are about 0.02%.  You'd have to talk to tens of thousands of forums members to find one who had it that early.

[kurdishfella]

Sorry to burst your bubble, but likely just a bad flu.  Under 10,000 active cases in January in the USA means your chances of having it then are about 0.02%.  You'd have to talk to tens of thousands of forums members to find one who had it that early.

I live in sweden I think is the only place that didn't shut down so I had it. 

 

I have never had a period were I sneeze for so long. I sneeze maybe few times a week for the last 6 months now.

Also I have other side effects like I felt burning in my lungs. And I felt pain in my left side of neck were lymph nodes are(among other negative effects but not that as harsh they seem mild), it's my body trying to get rid of it. Maybe I just have the non-mutated version which is not as bad. Either I have been reinfected or it has lasted for 6 months now.. 

 

Edited by kurdishfella, 02 July 2020 - 03:31 PM.

[Gal220]

@kurdishfella were you taking  quercetin, hesperdin, or any other supplements for prevention like a multivitamin?

[kurdishfella]

@kurdishfella were you taking  quercetin, hesperdin, or any other supplements for prevention like a multivitamin?

At first I was taking lithium which has been shown to inhibit virus DNA replica or something, but that quickly ran out. Then I ended up with vitamin E, A and D. Vitamin E has ran out (not sure it did much either). Now I currently take 10000 IU vitamin d daily which I can feel working and about equal amount of vitamin A (7500 mcg) daily which I feel nothing from all for the immune system. Oh yeah and I was also taking vitamin c (1000mg daily) before it ran out (don't feel like resupplying again though wastin cash feels like which i've done plenty off) which had some little effect I guess. But vitamin D has the most effect that I can tell/notice myself. But this was after I felt like I was infected because i didn't feel like I wanna die just yet and still don´t.

Edited by kurdishfella, 02 July 2020 - 06:30 PM.

[gamesguru]

I live in sweden I think is the only place that didn't shut down so I had it.

 

Nobody was locked down in January so it is a poor assumption Sweden would have a head start.  If anything, it had a lag behind, due to being a small, somewhat secluded nation with few direct ties to China.  Most of the cases in January were either in China, Italy, Iran, or some new budding epicenters such as Seattle or New York.

[lancebr]

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Study Shows

 

https://www.henryfor...treatment-study

 

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the

system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared

to 26.4% not treated with hydroxychloroquine.

 

“What we think was important in our study, in our patients, is that patients were treated early,” Dr. Marcus J. Zervos

said. “For hydroxychloroquine to have benefit, it has to be given before the patient suffers some of the severe immune

reaction that can occur with COVID-19.”

[gamesguru]

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Study Shows

 

https://www.henryfor...treatment-study

 

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the

system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared

to 26.4% not treated with hydroxychloroquine.

 

“What we think was important in our study, in our patients, is that patients were treated early,” Dr. Marcus J. Zervos

said. “For hydroxychloroquine to have benefit, it has to be given before the patient suffers some of the severe immune

reaction that can occur with COVID-19.”

 

Interesting, however the authors themselves conclude by noting:

Prospective trials are needed to examine this impact.

 

 

This review is being lauded as highly scrutinized and definitive, when in fact it is yet neither of those things.

[geo12the]

 

 

“What we think was important in our study, in our patients, is that patients were treated early,” Dr. Marcus J. Zervos

said. “For hydroxychloroquine to have benefit, it has to be given before the patient suffers some of the severe immune

reaction that can occur with COVID-19.”

 

 

FWIW that is exactly what my Pulmonologist brother told me were his observations a couple of months ago 

[Mind]

Treatment with Hydroxychloroquine Cut Death Rate Significantly in COVID-19 Patients, Study Shows

 

https://www.henryfor...treatment-study

 

In a large-scale retrospective analysis of 2,541 patients hospitalized between March 10 and May 2, 2020 across the

system’s six hospitals, the study found 13% of those treated with hydroxychloroquine alone died compared

to 26.4% not treated with hydroxychloroquine.

 

“What we think was important in our study, in our patients, is that patients were treated early,” Dr. Marcus J. Zervos

said. “For hydroxychloroquine to have benefit, it has to be given before the patient suffers some of the severe immune

reaction that can occur with COVID-19.”

 

 

There are 2 "junk studies" (one completely faked - as far as I can discern) that showed HCQ was harmful (touted very very very loudly by mainstream media outlets, btw)

 

There are a handful of very small studies which showed little to no benefit (benefits, yes, but not statistically significant).

 

The largest studies (Raoult) in France and now this one have shown dramatic benefits.

 

In addition, most doctors, when polled, say it is beneficial.

 

In addition Dr. Zelenko in New York continues to treat people succesfully in New York (hundreds of patients, but perhaps more than 1,000 by now).

 

I have mentioned it a couple of times already, it seems the best bet for treating COVID (presently) at the least cost, is HCQ+anitbiotic+zinc+other low-dose essential nutrients.

[gamesguru]

What's concerning about this recommendation that the drug be given early is basically you could wind up with people taking it for years at a time out of compulsive fear, which is exactly the duration of use under which it is likeliest to produce adverse effects and death.

 

Everyone knows (even intuitively) it has the highest cardiac risk, highest psychiatric and endocrine effects when taken in high doses over long periods.

 

What the right-wing homeopathic wanna-be witch doctors are out there doing is peddling a moderately offensive immno-suppressant anti-malarial as some miracle cure to this new virus.  They completely lack the foresight of mind to see the situation this created with hoarding and shortages, and how this kind of scientific misinformation basically encourages frightened old people with weak hearts to kill themselves.  Ah, we never get anywhere

[Mind]

Yet another study showing the benefits of essential nutrients such as D and B12 (which have been discussed in this thread quite often). 

 

https://www.medrxiv....6.01.20112334v2

 

It is not rocket-science. This thread is full of studies and data showing beneficial effects of essential nutrients in the treatment of COVID-19. None of them are "silver-bullets", which should not be expected, however, older and damaged immune systems respond favorably to proper nutrition - this is not in dispute - it is backed by decades of research.

 

Just think of how close we would be to "back to normal", if national media outlets were focused on treatments (like we are here in this thread), instead of pumping out constant "fear porn".

[gamesguru]

Yes it's amazing how the study also involves MAGNESIUM, one of the MOST COMMON first world NUTRIENT DEFICIENCIES.  Zinc advocates will be the first to neglect this key element, absorption of which are in competition with each other.

 

Magnesium and Immune Function: Recent Findings


Abstract

Recent findings regarding roles for magnesium in immunocompetence confirm and extend previous knowledge of its participation in natural and adaptive immunity. The detrimental effects of severe magnesium deficiency have been confirmed. There is better comprehension of how magnesium relates to mechanisms that control cellular activities and regulate interactions among cells that affect immune functions. Insight has been gained into how magnesium status affects susceptibility to physiological disorders, such as cardiomyopathy and cancer, that are exacerbated by inflammation and by the chemical mediators of anaphylaxis. More information is needed about the impact of less severe magnesium deficiency and of supplemental magnesium on indicators of immune function. Future studies should explore interactive relationships between Mg and such nutrients as vitamin D to elucidate more completely the roles that Mg can play in optimizing immune function.

 

 

What also amazes me is the tendency of individuals to run with such conclusions as some sort of endorsement for mega-dosing quackery?  If you're not deficient, there's likely NO benefit, as the agencies set the threshold for deficiency so high that 80% of people have problems meeting it.  So therefore to properly rule out the idea that there are no benefits beyond correcting a deficiency, we would have to conduct studies on only non-deficient volunteers, which constitute less than 20% of the population.

 

Notice how the below study modestly suggests supplementation may be beneficial for those at a suspected deficiency, not that everyone should go charging in like Galahad in with long-term regimens of 5,000 IU daily.  That's my gripe with the internet for today.  Thank you, stay curious, stay skeptical!

 

Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2, and thrombosis (R1).

BACKGROUND: SARS-CoV-2 coronavirus infection ranges from asymptomatic through to fatal COVID-19 characterised by a "cytokine storm" and lung failure. Vitamin D deficiency has been postulated as a determinant of severity.

OBJECTIVES: To review the evidence relevant to vitamin D and COVID-19 METHODS: Narrative review

RESULTS: Regression modelling shows that more northerly countries in the Northern Hemisphere are currently (May 2020) showing relatively high COVID-19 mortality, with an estimated 4.4% increase in mortality for each 1 degree latitude north of 28 degrees North (P=0.031) after adjustment for age of population. This supports a role for ultraviolet B acting via vitamin D synthesis. Factors associated with worse COVID-19 prognosis include old age, ethnicity, male sex, obesity, diabetes and hypertension and these also associate with deficiency of vitamin D or its response. Vitamin D deficiency is also linked to severity of childhood respiratory illness. Experimentally, vitamin D increases the ratio of angiotensin converting enzyme 2 (ACE2) to ACE, thus increasing angiotensin II hydrolysis and reducing subsequent inflammatory cytokine response to pathogens and lung injury.

CONCLUSIONS: Substantial evidence supports a link between vitamin D deficiency and COVID-19 severity but it is all indirect. Community-based placebo-controlled trials of vitamin D supplementation may be difficult. Further evidence could come from study of COVID-19 outcomes in large cohorts with information on prescribing data for vitamin D supplementation or assay of serum unbound 25(OH) vitamin D levels. Meanwhile vitamin D supplementation should be strongly advised for people  likely  to be deficient.

Edited by gamesguru, 04 July 2020 - 08:58 PM.

[pamojja]

It is not rocket-science. This thread is full of studies and data showing beneficial effects of essential nutrients in the treatment of COVID-19. None of them are "silver-bullets", which should not be expected, however, older and damaged immune systems respond favorably to proper nutrition - this is not in dispute - it is backed by decades of research.

 
Also my experience with orthomolecular medicine: chronic conditions considered non-reversible by conventional medicine went all in remission with just most of the essential nutrients (PAD, COPD, NAFLD, CKD, ME/CFS, T2D), some phytonutrients and lifestyle changes.
 
And if one considers that all studies find above 90% - even up to 99% covid-19 deaths - with same of such comorbities, it is not too far-feched to say, almost no-one would die without.
 

What also amazes me is the tendency of individuals to run with such conclusions as some sort of endorsement for mega-dosing quackery?  If you're not deficient, there's likely NO benefit, as the agencies set the threshold for deficiency so high that 80% of people have problems meeting it.

 

In my case with multiple tested for deficiencies, mega-dosing was the key. However testifying to it, isn't automatically an endorsement.

 

What I do however endorse in every case is laboratory testing for deficiencies. Supplementing those starting with lowest possible doses, and increasing gradually over weeks, months and years, while monitoring labs to find the opptimal dose of each nutrient to correct deficiency. And take whatever it takes.

 

In lack of access of some lab-test, one also can titrate slowly to find optimal doses by remission from symptoms, of course. Main available lab-tests should however always be monitored despite, and especially high dose anything.

[resveratrol_guy]

Ivermectin has only been tested in vitro as an antiviral for coronavirus. With these in vitro tests, they will determine the concentration of the substance which inhibits viral replication by 50% in a cell line in a petri dish. That concentration is known as the EC50 or IC50.

 

In order to have an antiviral effect in vivo, you have to attain at least the same concentration in the blood. To work out the concentration achieved in the blood when you take an substance orally, you use pharmacokinetic data and calculations. A lot of the time, it is not possible to achieve in the blood the same high concentration that were used in vitro, because of limiting factors such as oral bioavailability and plasma protein binding. 

 

And according to my pharmacokinetic calculations, the oral ivermectin dose required to achieve the EC50 is far, far too high. So ivermectin does not look like it will be clinically useful as a antiviral for coronavirus.

 

It is however possible that ivermectin might have some immune-boosting effects which might be useful.

 

Any reduction in viral replication rate provides an advantage to the immune system. It's just a question of whether or not it's sufficient to win the war. Early in the course of disease, it might be, because during that time the most important consideration is viral load. Even extending things by a single day might make the difference between preventing or facilitating a cytokine storm down the road. So while I take you at your word that the ivermectin dose in question is insufficient to inhibit viral replication by 50% (over what time period?), that doesn't preclude the hypothesis that said dose could explain a decrease in patient mortality.

 

Of course, you might be right. It might be some other mechanism entirely. Either way, it seems that the evidence is mounting in this thread, and elsewhere, that this stuff works synergistically with other therapies to boost survival, although the sooner the better after diagnosis. I would drink it again if I got the virus, not because I'm completely convinced of its efficacy, but because I think the risk/reward ratio is compelling.

 

Edited by resveratrol_guy, 05 July 2020 - 12:59 PM.

[lancebr]

Low plasma 25(OH) vitamin D3 level is associated with increased risk of COVID-19 infection: an Israeli population-based study

 

https://www.medrxiv....7.01.20144329v1

 

"Suboptimal" or "low" plasma 25(OH)D level was defined as plasma 25-hydroxyvitamin D, or 25(OH)D, concentration below 30 ng/mL.

 

Results: Of 7,807 individuals, 782 (10.1%) were COVID-19-positive, and 7,025 (89.9%) COVID-19-negative. The mean plasma vitamin D

level was significantly lower among those who tested positive than negative for COVID-19

Edited by lancebr, 05 July 2020 - 10:08 PM.

[Gal220]

 Either way, it seems that the evidence is mounting in this thread, and elsewhere, that this stuff works synergistically with other therapies to boost survival, although the sooner the better after diagnosis. I would drink it again if I got the virus, not because I'm completely convinced of its efficacy, but because I think the risk/reward ratio is compelling.

 

 

Did you do anything else as part of your protocol? Like NAC, glutathione (Lungs) , Natto (clots) or potassium (probably require IV)?

 

Are you doing anything preventative now like ashwagandha , quercetin, hesperidin or a multivitamin?

[lancebr]

Ivermectin for COVID-19 Treatment: Clinical Response at Quasi-Threshold Doses Via Hypothesized Alleviation of CD147-Mediated Vascular Occlusion

 

https://papers.ssrn....ract_id=3636557

 

"It is proposed that higher doses of IVM could yield sharply greater clinical benefits. In several clinical studies, IVM at doses of up to 2,000 µg/kg, ten times that used in the Florida study, were well tolerated. The potential for major dose-response gains is evaluated based upon studies indicating that IVM shields SARS-CoV-2 spike protein and that this spike protein binds to the CD147 transmembrane receptor as well as to ACE2. The abundant distribution of CD147 on red blood cells (RBCs) suggests a hypothesized “catch” and “clump” framework whereby virally-mediated bindings of RBCs to other RBCs, platelets, white blood cells and capillary walls impede blood flow, which in turn may underlie key morbidities of COVID-19."

 

Below is a more detailed pdf of the information....it appears from this information that Ivermectin could reduce or prevent the blood clotting that appears to be deadly in Covid19

 

https://poseidon01.s...2083093&EXT=pdf

 

 

Edited by lancebr, 06 July 2020 - 06:26 AM.

[Daniel Cooper]

 

What the right-wing homeopathic wanna-be witch doctors are out there doing is peddling a moderately offensive immno-suppressant anti-malarial as some miracle cure to this new virus.  They completely lack the foresight of mind to see the situation this created with hoarding and shortages, and how this kind of scientific misinformation basically encourages frightened old people with weak hearts to kill themselves.  Ah, we never get anywhere

 

Continued ad hominem comments will result in a time out.

 

We are hear to debate ideas, not attack people.  People with whom you disagree are not "witch doctors" because you disagree with them.

 

Understand?

Edited by Daniel Cooper, 06 July 2020 - 02:07 PM.

[lancebr]

Melatonin and COVID-19: More Studies Emerging That Melatonin Is Useful As An Adjuvant Treatment For COVID-19 Due to Its Anti-Inflammatory Properties.

 

https://www.thailand...ory-properties-

[joelcairo]

This study appeared in my inbox today for a Google Alert on a completely different subject. It's just an in silico (i.e. computer) study, but melatonin has been mentioned several times in this thread and this article goes into some specific reasons why it could be of help.

 

Going off on a tangent slightly, melatonin also has significant support as a cancer preventive/treatment. I mean it can show some really significant effects. If it works so well, what would happen if you too it all day to keep your levels up? You'd be somewhat groggy depending on the dosage and your personal sensitivity, but I wonder if that strategy would be twice as effective as if you only took it at night.

 

COVID-19: Rational discovery of the therapeutic potential of melatonin as a SARS-CoV-2 main protease inhibitor

(online in .doc format)

 

https://www.medsci.o...pub/48053k2.doc

Edited by joelcairo, 07 July 2020 - 03:31 AM.

[DanCG]

 If it works so well, what would happen if you too it all day to keep your levels up? You'd be somewhat groggy depending on the dosage and your personal sensitivity, but I wonder if that strategy would be twice as effective as if you only took it at night.

 

 

If you were actually sick with COVID, so what if you got drowsy from taking melatonin all day. You should be resting anyway.

[joelcairo]

That's my thinking, if you're taking it for a limited time. Of course every instruction I've ever seen for how to take it specifies only taking it at or before bedtime. For longterm preventative use I'm sure it would mess up all kinds of body systems that rely to some extent on the circadian rhythm.

Edited by joelcairo, 07 July 2020 - 05:44 PM.

[lancebr]

Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management

 

https://www.medrxiv....7.07.20145979v1

 

Methods:

 

"This Pilot clinical trial conducted on hospitalized adult patients with mild to moderate COVID-19 diagnosed according to WHO interim guidance. Sixteen Patients received a single dose of IVM 200Mcg /kg on admission day as add on therapy to hydroxychloroquine ( HCQ) and Azithromycin (AZT) and were compared with 71 controls received HCQ and AZT matched in age, gender, clinical features, and comorbidities. The primary outcome was percentage of cured patients, defined as symptoms free to be discharged from the hospital and 2 consecutive negative PCR test from nasopharyngeal swabs at least 24 hours apart. The secondary outcomes were time to cure in both groups and evaluated by measuring time from admission of the patient to the hospital till discharge."

 

Results:

 

"Of 87 patients included in the study, the mean age ± SD (range) of patients in the IVM group was similar to controls [44.87 ± 10.64 (28-60) vs 45.23 ± 18.47 (8-80) years, p=0.78] Majority of patients in both groups were male but statistically not significant [11(69%) versus 52 (73%), with male: female ratio 2.21 versus 2.7-, p=0.72) All the patients of IVM group were cured compared with the controls [ 16 (100 %) vs 69 (97.2 %)]. Two patients died in the controls. The mean time to stay in the hospital was significantly lower in IVM group compared with the controls (7.62 ±2.75 versus 13.22 ±.90 days, p=0.00005, effect size= 0.82). No adverse events were observed"

 

Conclusion:

 

"Add-on use of IVM to HCQ and AZT had better effectiveness, shorter hospital stay, and relatively safe compared with controls. however, a larger prospective study with longer follow up may be needed to validate these results."

Edited by lancebr, 08 July 2020 - 11:06 PM.

[bladedmind]

NAC for blood clotting.

 

Dr. Seheult’s Medcram hasn’t been cited in a while. I did speed browsing of the last 20 episodes.  

 

Recall his personal regimen at episode 59 of Vitamins C, D, Zinc, Quercetin, and NAC. 

 

He’s a theorist and active clinician, and is optimistic about the emerging standard of care, especially dexamethasone, also remdesivir, tocilizumab, convalescent plasma, proning.   Plus, little risk and likely benefit by adding his personal regimen.  Open-minded on HCQ, awaiting more RCT evidence. 

 

Episode 83 advised to lower fructose reduction, lower BMI.

 

Episodes 84 and 85 are what questions to ask upon arrival at hospital.  I'm assigning those to my son. 

 

Episode 90 is a classy slap back at Youtube’s censoring of his videos.  Without the slightest snark or hint of vindictive pride, he reviews a published study of the quality of Covid-19 Youtube videos.  Wherein MedCram outscored all other sources examined. 

 

Episode 92 is of greatest interest.  Several here have wondered what we can do to guard against and mitigate the coagulatory attack; and remedies offered have been uncertain.  Here is his summary:

 

There is mounting evidence that COVID-19 has a profound impact on the endothelium (the lining of blood vessels) which may explain the observed blood clots associated with this pandemic. Roger Seheult, MD of https://www.medcram.com discusses new research from the Lancet on coagulopathies (clotting or bleeding problems) in COVID-19 and explains how reactive oxygen species (ROS) may set the stage for clotting. Dr. Seheult also illustrates how the supplement N-acetylcysteine (NAC) may be beneficial to reduce excess ROS and prevent blood clots. Sloan Kettering is performing a clinical trial that studies N-acetylcysteine (NAC) with COVID 19 infec tion.

 

https://youtu.be/kK-DNyKnb5c

 

Also, he now holds a weekly Q&A separate from the series.  In one of those - I didn't take note - someone asked about ivermectin.  An initial dose of ivermectin is standard at the two hospitals he works in. 

 

Edited by bladedmind, 09 July 2020 - 04:04 AM.

[Gal220]

I'm surprised that it's taken this long to figure this out.  I would think a corticosteroid would have been tried very early on in a disease where cytokine storm is a major contributor to mortality.  

 

I had assumed that corticosteroids had been tried and found not to help.  It's such an obvious thing to try.

 

In a similar vein

 

West Texas doctor claims to have “silver bullet” for COVID-19

 

“The treatment plan is inhaled, generic budesonide,” Bartlett said. “Using some generic antibiotics to protect from a secondary bacterial infection. Using zinc, which interferes with virus replication. It’s common sense. It’s intuitive.”

Budesonide is a steroid, that can be inhaled directly to the lungs using a nebulizer.

 

Bartlett said he treats people as soon as they show symptoms.

“Early treatment is better with this disease,” he said. “And I’m having a 100% survival rate. I don’t even know how many I’ve treated...dozens. I have 14 that I’m treating right now.”

Bartlett said that patients tell him they feel immediate relief."

Edited by Gal220, 09 July 2020 - 11:14 AM.

[Gal220]

NAC for blood clotting.. 

 

Episode 92 is of greatest interest.  Several here have wondered what we can do to guard against and mitigate the coagulatory attack; and remedies offered have been uncertain.  Here is his summary:

 

https://youtu.be/kK-DNyKnb5c

 

 

I like the idea, but I would still use Natto or some other proteolytic enzymes enzyme(serracor /block buster all clear) to destroy clots and excess fibrin, especially if your blood pressure isnt optimal already(below 120/80).

 

Is Natto the safest blood thinner?

Edited by Gal220, 09 July 2020 - 11:12 AM.

[lancebr]

A Combination of Ivermectin and Doxycycline Possibly Blocks the Viral Entry and Modulate the Innate Immune Response in COVID-19 Patients

 

https://chemrxiv.org.../files/23757572

 

"In the current study we have explored the possible mechanism by which these drugs might have worked for the positive response in the COVID-19 patients. To explore the mechanism we have used molecular docking and molecular dynamics simulation approach. Effectiveness of Ivermectin and doxycycline were evaluated against Main Protease (Mpro), Spike (S) protein, Nucleocapsid (N), RNA-dependent RNA polymerase (RdRp, NSP12), ADP Ribose Phosphatase (NSP3), Endoribonuclease (NSP15) and methyltransferase (NSP10-NSP16 complex) of SARS-CoV-2 as well as human angiotensin converting enzyme 2 (ACE2) receptor.

 

Our study shows that both Ivermectin and doxycycline have significantly bind with SARS-CoV-2 proteins but Ivermectin was better binding than doxycycline. Ivermectin showed a perfect binding site to the Spike-RBD and ACE2 interacting region indicating that it might be interfering in the interaction of spike with ACE2 and preventing the viral entry in to the host cells. Ivermectin also exhibited significant binding affinity with different SARS-CoV-2 structural and non-structural proteins (NSPs) which have diverse functions in virus life cycle. Significant binding of Ivermectin with RdRp indicate its role in the inhibition of the viral replication and ultimately impeding the multiplication of the virus. Ivermectin also possess significant binding affinity with NSP3, NSP10, NSP15 and NSP16 which helps virus in escaping from host immune system. Molecular dynamics simulation study shows that binding of the Ivermectin with Mpro, Spike, NSP3, NSP16 and ACE2 was quiet stable."

Edited by lancebr, 09 July 2020 - 10:46 PM.

[bladedmind]

Thanks, Gal220, for the remarks on Natto.    

 

https://youtu.be/kK-DNyKnb5c

Seheult is not saying, oh, here is another antiplatelet therapy among others.  He’s saying that NAC could be exactly appropriate to sunder the causal chain leading from the virus to thrombosis.  Implying that it could be great for prophylaxis and treatment. 

 

I don’t understand biochemistry and won’t try to fake it - I’m paraphrasing language I half understand.   Earlier (Episode 69), Seheult offered a detailed hypothesis -- the endothelial oxidative stress hypothesis -- about the biochemical mechanism leading from Sars Cov-2 to thrombosis.  In Episode 92, he reviews it again, and reports on a new article in NEJM and another in Lancet that in different ways lend support to the hypothesized mechanism.   The Lancet article proposes antiplatelet therapy, mentioning dipyridamole (easy to get from India pharmacies by the way) and two others as candidates to test. 

 

Seheult suggests that NAC is a better candidate to trial because 1) it is an antioxidant and recharges the glutathione peroxidase mechanism, and thus weakens two steps in the causal chain from the virus to the thrombosis, and 2) it disrupts a third step in the chain (VWF antigen).  And there is already a trial of NAC in progress - in hospital, 6g of intravenous NAC per day for three weeks.  Seheult’s “personal regimen” (not “advice”) reported in Episode 59 includes 600 mg of oral NAC twice a day, for the duration.