3083 replies to this topic

[Gal220]

Another reason to love Quercetin(best taken with vit c or bromelain) - Link1, Link2

 

"Quercetin fights prions

Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress"

 

Some discussion about prions here - LINK(page down 4 times)

Edited by Gal220, 01 August 2021 - 04:26 PM.

[DanCG]

 

Some discussion about prions here - LINK(page down 4 times)

Hey everybody don’t skip this. My interpretation: continue taking quercetin if you have been vaccinated or after you have had the infection.

[smithx]

Cochrane Review: Ivermectin for preventing and treating COVID‐19

Based on the current very low‐ to low‐certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent COVID‐19. The completed studies are small and few are considered high quality. Several studies are underway that may produce clearer answers in review updates. Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials.

 

https://www.cochrane...15017.pub2/full

 

 

This is a comprehensive review article. They don't say it doesn't work, but evidence according to their process is still equivocal.

Edited by smithx, 02 August 2021 - 05:13 AM.

[Advocatus Diaboli]

Re Cochrane review link

 

"Main results

 

We found 14 studies with 1678 participants investigating ivermectin compared to no treatment, placebo, or standard of care. No study compared ivermectin to an intervention with proven efficacy. There were nine studies treating participants with moderate COVID‐19 in inpatient settings and four treating mild COVID‐19 cases in outpatient settings. One study investigated ivermectin for prevention of SARS‐CoV‐2 infection. Eight studies had an open‐label design, six were double‐blind and placebo‐controlled. Of the 41 study results contributed by included studies, about one third were at overall high risk of bias. 

 

Ivermectin doses and treatment duration varied among included studies.

 

We identified 31 ongoing and 18 studies awaiting classification until publication of results or clarification of inconsistencies."

 

Instead of writing "Of the 41 study results contributed by included studies, about one third were at overall high risk of bias.", I wonder why they just didn't spit out a number, like 13 or 14, and then tell us how the 13 or 14 studies broke down into the inpatient/outpatient categories. That would be inportant information to know. I don't know if "41" in the above is a typo for "14" or if the 14 studies they used somehow incorporated ("contributed by", whatever that means) the results of 41 other studies of which "about one third were at overall high risk of bias". Anyway...

 

"Ivermectin doses and treatment duration varied among included studies."

 

I suspect that doses and treatment duration are very important metrics to assess when trying to gauge the efficacy of of a drug. And yet, the authors apparently blindly forged ahead with their study unaware (?) that their conclusions would surely be affected by those variables.

 

"We identified 31 ongoing and 18 studies awaiting classification until publication of results or clarification of inconsistencies."

 

Great find, one of monumental proportions. So glad they included that declaration.

 

"Authors' conclusions

 

Based on the current very low‐ to low‐certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent COVID‐19. The completed studies are small and few are considered high quality. Several studies are underway that may produce clearer answers in review updates. Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of COVID‐19 outside of well‐designed randomized trials."

 

From the above:

 

"The completed studies are small and few are considered high quality."

 

And yet those studies appear to be "the reliable evidence " on which the authors base thier conclusions. Gotcha.

 

 

I rate the paper "F". (There are other problems, too, but why bother beating a dead horse?)

[Gal220]

They added Quercetin to the list!

 

https://c19early.com/

 

 

[Gal220]

This is a comprehensive review article. They don't say it doesn't work, but evidence according to their process is still equivocal.

 

Kory had an interesting take on it.

https://twitter.com/...284834337456129

[Daniel Cooper]

They added Quercetin to the list!

 

https://c19early.com/

 

Interesting. I remember saying here early on that looking at the few studies that were available in the first 6 months of the pandemic that my take was that hydroxychloroquine and remdesivir seemed to have roughly the same level of effectiveness.  The former being well known, well tolerated, and fantastically cheap whereas the latter was new, relatively untested with unknown side effects, and very expensive. So naturally the FDA would support remdesivir over HCQ.  

 

I'd challenge anyone to come up with a finer example of regulatory capture than the FDA and the pharmaceutical industry.

[geo12the]

 

 

I'd challenge anyone to come up with a finer example of regulatory capture than the FDA and the pharmaceutical industry.

 

I would say the latest approval of the aducanumab for Alzheimers was the worst such example. 

[geo12the]

This is a comprehensive review article. They don't say it doesn't work, but evidence according to their process is still equivocal.

 

Yes my takeaway is "Several studies are underway that may produce clearer answers in review updates"

[DanCG]

Yes my takeaway is "Several studies are underway that may produce clearer answers in review updates"

My prediction is that the studies that are underway will be inconclusive as well. I don’t know the details, but I will bet that the trials are not set up to test the way people who are claiming efficacy actually use ivermectin. Look for lack of co-administration of other agents. For example, every protocol I have seen calls for zinc. Usually a macrolide is included, and a glucocorticoid for advanced cases. Depending on exactly what is done, it may seem to work in some trials but not in others, just like in the trials we already have. The debate will go on. I hope I am wrong about this.

[Qowpel]

I wouldnt change a thing, more importantly if I got vaccinated, I would add a blood cleanser like neprinol afd or serracor nk to minimize the circulating spike protein and blood clots that result from it.

I think vaccine injury could be dramatically reduced if health agencies were more proactive.

 

I will look for the link, one doctor noted a huge drop in vitamin D from the vaccine, make sure you are 

I am getting J and J tomorrow.

 

Do you reccomend I take aspirin daily to avoid the clots, in addition to the serrakor I will take. Or do you think the aspirin will mess with vaccine effectiveness?

 

For the record I will continue taking my zinc, quercetin, vitamin c, and egcg and NAC

 

I heard vitamin e may be smart for the anti thrombroycytopenia

[Dorian Grey]

Congratulations on joining the herd Q.  I've slept a lot easier since I got my one-and-done J&J jab.  Haven't worn a mask in over a month now.  

 

Aspirin is probably the most potent over the counter anticoagulant.  The stuff wrecks my gut though, even the low dose (81mg) "baby" aspirin; speaking of which, is probably all you need.  

 

There are several supplements known to thin blood too.  Vitamin-E is probably most effective: 

 

https://www.epainass...-blood-thinners

 

You probably don't need any big-guns anti-coagulation, so what ever is easiest should be fine.  

 

 

 

[Gal220]

I am getting J and J tomorrow.

 

Do you reccomend I take aspirin daily to avoid the clots, in addition to the serrakor I will take. Or do you think the aspirin will mess with vaccine effectiveness?

Serracor will take care of any clots, hopefully the spike protein too. no need for aspirin

[Gal220]

Serracor will take care of any clots, hopefully the spike protein too. no need for aspirin

Serracor and Neprinol are made by companies that specialize in enzymes - LINK1, LINK2

Edited by Gal220, 03 August 2021 - 04:06 PM.

[Gal220]

VEDICINALS® 9

 

"Here you find a detailed description of the 9 bioactive molecules used in VEDICINALS® 9 and their documented efficacy against SARS-CoV-2 Coronavirus and Covid19 disease."

 

Long Covid also

[Hebbeh]

Rethinking remdesivir: Researchers modify current drug, creating oral version that can be taken earlier in COVID-19 diagnoses -- ScienceDaily

 

Remdesivir is an antiviral drug originally discovered as part of a program to develop antiviral agents with activity against novel emerging viruses. In the first months of the COVID-19 pandemic, it was tested as a potential therapeutic and found to measurably reduce recovery time for hospitalized COVID-19 patients. The Food and Drug Administration approved its use in October 2020 and it remains the only FDA-approved antiviral for treatment of SARS-CoV-2 infection.

 

Currently, remdesivir must be administered intravenously, a process that restricts its use to patients hospitalized with relatively severe or advanced cases of COVID-19. The FDA has approved the use of remdesivir only for adults and children age 12 and older.

 

In a new paper, published in the July 26, 2021 online issue of Antimicrobial Agents and Chemotherapy, researchers at University of California San Diego School of Medicine describe cell and animal studies that demonstrate how lipid modifications of remdesivir nucleoside can improve drug delivery, effectiveness and toxicity compared to remdesivir.

 

Senior author Karl Hostetler, MD, professor of medicine at UC San Diego School of Medicine, and colleagues synthesized three new lipid prodrugs, which combine a therapeutic agent (in this case, remdesivir nucleoside) with one of several types of lipid-phosphates. The resulting conjugated molecule uses new pathways to enter cells: the lipid phosphate portion carrying along the drug.

 

The lipid phosphate prodrugs of the remdesivir nucleoside can be taken orally, remaining intact and bioactive in the body following absorption from the digestive system.

 

"COVID-19 is a two-stage disease," said Schooley. "Rapid viral growth occurs shortly after infection and can trigger a misdirected immune response that results in an 'inflammatory' pneumonia in those who don't do well. In order to be maximally effective, antiviral therapy must be given early in the illness before the inflammatory phase of the illness results in hospitalization. These compounds are designed to be taken orally, rapidly absorbed from the gastrointestinal tract and to largely bypass the liver where most of remdesivir's toxicity is seen."

 

To become active, remdesivir requires modification by multiple enzymes. This complicated metabolism likely contributes to variable antiviral activity and toxicity in different cell types. For example, remdesivir works well in lung cells, but is less effective in other organs and is relatively more toxic in hepatocytes (liver cells), which limits the amount of drug that can be administered to patients. In comparison, the lipid prodrugs described in the new paper are activated by a simple single enzymatic reaction and show a consistently potent antiviral activity and minimal toxicity across many cell types.

 

"An optimal antiviral for the treatment of SARS-CoV-2, and potentially other emerging viral infections, would be equally effective in any cell type that could be infected," said co-first author Aaron F. Carlin, MD, assistant professor of medicine and an infectious disease specialist at UC San Diego Health. "The metabolism of remdesivir is complex, which may lead to variable antiviral activity in different cell types. In contrast, these lipid-modified compounds are designed to be activated in a simple uniform manner leading to consistent antiviral activity across many cell types."

 

rest at link

[Dorian Grey]

Breaking News: Mr Science himself Tony Fauci has had a brilliant brainstorm!  

 

The possibility of an early, oral outpatient therapeutic, that might reduce severe disease, hospitalization, and reduce deaths!

 

You just give it to patients as soon as they are diagnosed, and head advanced disease off at the pass.  

 

 

Anyone have any ideas?  Anyone have his email address?  

Edited by Dorian Grey, 04 August 2021 - 01:51 AM.

[Qowpel]

Serracor and Neprinol are made by companies that specialize in enzymes - LINK1, LINK2

should i take it once per day or twice per day? (serracor)

[Daniel Cooper]

Breaking News: Mr Science himself Tony Fauci has had a brilliant brainstorm!  

 

The possibility of an early, oral outpatient therapeutic, that might reduce severe disease, hospitalization, and reduce deaths!

 

You just give it to patients as soon as they are diagnosed, and head advanced disease off at the pass.  

 

 

Anyone have any ideas?  Anyone have his email address?  

 

Since the post above you announced that an oral form of remdesivir is becoming available, I'm going to guess that Fauci is going to recommend a safe, effective, readily available, and cheap drug ...... ivermectin.

 

Nah, just kidding .... he's about to tout oral remdesivir.

[Mind]

Just another RCT study showing the benefits of Ivermectin.....add it to dozens of others.

 

Surely to be ignored by the CDC, FDA, WHO. Surely to be censored out of US national media. Surely to be banned from discussion on social media.

[DanCG]

Just another RCT study showing the benefits of Ivermectin.....add it to dozens of others.

 

Surely to be ignored by the CDC, FDA, WHO. Surely to be censored out of US national media. Surely to be banned from discussion on social media.

It looks like the only treatments in this trial were ivermectin vs placebo. Still IVM showed a positive effect. For comparison, look at these notable protocols for how to use ivermectin at the comparable stage of disease.

 

McCullough, zinc, azithromycin, doxycyline, and either HCQ, IVM, or Favipiravir

 

Italian protocol: zinc, VitD, VitC, hesperidin,quercetin, lactoferrin, bromhexine, and more for asymptomatic, add aspirin, ivermectin, HCQ, azithromycin or doxycyline, colchicine, if symptoms.

 

FLCCC: zinc, VitD, VitC, aspirin, quercetin, melatonin, nasal sanitation, IVM, and fluvoxamine

 

The trial I would like to see would compare one of these complete protocols vs the same protocol without ivermectin vs placebo.

Edited by DanCG, 05 August 2021 - 01:37 AM.

[DanCG]

VEDICINALS® 9

 

"Here you find a detailed description of the 9 bioactive molecules used in VEDICINALS® 9 and their documented efficacy against SARS-CoV-2 Coronavirus and Covid19 disease."

 

Long Covid also

It's almost like they read this forum and picked an all-star team.

[Gal220]

Sign of things to come, Mercola taking all his content down.

 

https://articles.mer...r-48-hours.aspx

[Dorian Grey]

Sign of things to come, Mercola taking all his content down.

 

https://articles.mer...r-48-hours.aspx

 

Saw this earlier today on another forum, & thought of you Gal.  Apparently the result of the New York Times article that named Mercola the Number 1 purveyor of misinformation in the US (World?).  

 

Not enough bad news for one day?  How 'bout this: https://anh-usa.org/...or-supplements/

 

Clock Ticking For Supplements

 

"The FDA could be preparing to unleash an anti-supplement policy as early as next year that could eliminate tens of thousands of products from the market"

 

"Recently, the FDA announced that, by the end of June 2022, it plans to release drafts or final versions of a number of policies, and among them is the “new dietary ingredient” (NDI) guidance (“new supplement” guidance, in plain English). It is no exaggeration to say that this is the most dangerous threat to supplements we’ve seen in decades. "

 

------------------------

 

Walls closing in...  Free no more.  Glad I'm nearing the end of my journey, & came of age & enjoyed the glory days of the 70s, 80s & 90s.  Feel sorry for the kids, but then many of the young ones have evolved to tedious & insufferable basterds.  It's going to be a fine mess come mid century.  I'll see you on the dark side of the moon!  

[Gal220]

Not enough bad news for one day?  How 'bout this: https://anh-usa.org/...or-supplements/

 

Clock Ticking For Supplements

I added it to the NAC thread in Supplements section, Cooper has the right idea.

[DanCG]

 

 

 Glad I'm nearing the end of my journey,

 A man in his 60's says this at Longecity?!  C'mon man!

[Gal220]

Another reason to love Quercetin(best taken with vit c or bromelain) - Link1, Link2

 

"Quercetin fights prions

Quercetin Disaggregates Prion Fibrils and Decreases Fibril-Induced Cytotoxicity and Oxidative Stress"

 

Some discussion about prions here - LINK(page down 4 times)

 

More from Rhonda Patrick - LINK 

Another study used imaging data and found that people who had COVID-19, both severe and mild, lost a significant amount of gray matter in several brain regions compared to shortly before they had been infected with SARS-CoV2

 

A recovery protocol of some type would probably be in order.  Krill oil /fish oil 4g + vitamin e + choline  - LINK , LINK2

Edited by Gal220, 06 August 2021 - 12:59 AM.

[Gal220]

It's almost like they read this forum and picked an all-star team.

Not sure how much Glycyrrhizin(from licorice) is in it, but long term use isnt recommended as it lowers potassium leading to high blood pressure.

 

I would have licorice on hand if I had symptoms.

[Heisok]

They have made it clear from the start that changes would be made to each protocol when warranted. Over time, in the I-MASK + protocol for prevention and early outpatient treatment, FLCCC has gone from recommending 2 doses of Ivermectin followed by one dose every 4 weeks to 1 dose every 2 weeks to currently one dose every week.

 

https://covid19criti...-plus-protocol/

 

 

 

 

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[Gal220]

Long covid treatment protocol - LINK