3083 replies to this topic

[Dorian Grey]

The jury has reached a verdict.  It's Hydroxychloroquine!  

 

https://www.dailymai...-available.html

 

Malaria drug hydroxychloroquine is the most effective coronavirus treatment currently available, finds international poll of 6,000 doctors

 

The malaria drug hydroxychloroquine is the best coronavirus drug currently available, according to an international poll of thousands of doctors.   Of 6,200 physicians surveyed from 30 countries, the majority (37 per cent) said it was the 'most effective therapy' for the virus.

 

-----------------------

 

I expect old school chloroquine phosphate & quinine are most likely equally effective, as appears to be the case for malaria.

 

https://www.scienced...035920388904117

 

"Chloroquine (25 mg/kg over 3 d) was compared to quinine (10 mg/kg 3 times daily for 5 d) in 20 adult Filipino males with uncomplicated Plasmodium falciparum malaria in a double-blind, randomized trial. Asexual parasitaemia was cleared in all patients, with no statistically significant difference"

 

Interesting the effective dose for quinine appears to be substantially lower than for chloroquine.  Might lower doses of quinine be helpful at preventing mild COVID from advancing to advanced end stage disease, or perhaps be an effective prophylaxis?  Will your doctor or healthcare system provide this for you?  

 

I've been looking at Tonic Water as an available source for quinine.  Only problem I've seen is that most tonic waters contain a remarkable amount of sugar, & diet tonic is full of saccharin (artificial sweetener).  Discovered "Fever-Tree Refreshingly Light Premium Indian Tonic Water with Natural Quinine".  At only 30 calories per 6.8oz / 200ml, one might be able to get a fair amount of quinine without massive amounts of sugar.  

 

Quinine content of tonic water is limited to 83mg/liter, but I've had no luck finding the actual quinine content for any tonic water I've seen.  Have started my forlorn hope at prophylaxis by having a couple bottles of this before bed after dosing zinc with dinner.  If I get sick,I will add cimetidine (Tagamet) which inhibits metabolism of quinine and avoid caffeine/nicotine which increases metabolism of quinine.  

 

Wish me luck!  

Edited by Dorian Grey, 03 April 2020 - 03:36 PM.

[Daniel Cooper]

Preferred by 7 out of 10 doctors eh?  Sounds like they're marketing a toothpaste.

 

That's good and a step in the right direction, but saying that a poll of 6,200 doctors gave some response makes me wonder what data those 6,200 are looking at.  I just wish someone would write a quick report that summarizes the results from all the non-RCTs that have been done.  That's not asking for a lot.  I'd rather have that than some poll of thousands of doctors who may or may not know what the underlying data is.  Chances are, with that big of a pool most of them probably don't know anything more than what we've posted in this very thread.

 

 

 

 

[Izan]

“The results that we are starting to accumulate suggest that hydroxychloroquine administered early...is helping us prevent hospitals from filling up.”

 

-Dr. Pier Luigi Bartoletti, Deputy National Secretary of the Italian Federation of General Practitioners

 

https://www.trustnod...roxychloroquine

 

 

 

[Mind]

Preferred by 7 out of 10 doctors eh?  Sounds like they're marketing a toothpaste.

 

That's good and a step in the right direction, but saying that a poll of 6,200 doctors gave some response makes me wonder what data those 6,200 are looking at.  I just wish someone would write a quick report that summarizes the results from all the non-RCTs that have been done.  That's not asking for a lot.  I'd rather have that than some poll of thousands of doctors who may or may not know what the underlying data is.  Chances are, with that big of a pool most of them probably don't know anything more than what we've posted in this very thread.

 

They also voted Azithromycin as the second most effective treatment. It is kind-of meaningless without data, except that it is a large survey. Thousands of doctors are using these treatments and are seeing something positive in at least some patients. Better than the survey coming back and thousands of doctor saying the treatments are worthless.

[Daniel Cooper]

They also voted Azithromycin as the second most effective treatment. It is kind-of meaningless without data, except that it is a large survey. Thousands of doctors are using these treatments and are seeing something positive in at least some patients. Better than the survey coming back and thousands of doctor saying the treatments are worthless.

 

I agree.  I'm hopeful about hydroxychloroquine and seeing that many doctors are as well is encouraging.

 

I'm just frustrated that we don't seem to be able to get information from these non-controlled trials.  You could put the information I want to see on half a sheet of paper for each of these.

 

I hope that these 6,200 doctors are privy to more information than we are.

[lancebr]

Anyone who wants a deeper thought process on why Vitamin D is a good idea and why Chris Masterjohn/Andrew Weil are wrong, read this response to BMJ from Attila Garami, MD PhD.  He notes his views as 'hypothesized', but I think he is pretty much spot on.

 

https://www.bmj.com/.../bmj.m810/rr-24

 

Saw a post on another page about Vitamin D increasing IL-1B which they say you do not

want to happen if you get this virus:

 

https://www.ncbi.nlm...les/PMC3675149/

 

https://scholar.goog...monocytic cells

 

Any thought on that?

 

 

Edited by lancebr, 03 April 2020 - 07:22 PM.

[Izan]

About the potent antiviral activity of anthelmintic drugs:

 

 

Anti-parasitic drug Ivermectin kills COVID-19 in lab within 48 hours

 

An anti-parasitic drug available throughout the world has been found to kill COVID-19 in the lab within 48 hours. A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture. “We found that even a single dose could essentially remove all viral RNA (effectively removed all genetic material of the virus) by 48 hours and that even at 24 hours there was a really significant reduction in it,” Monash Biomedicine Discovery Institute’s Dr Kylie Wagstaff said on Friday. While it’s not known how Ivermectin works on the virus, the drug likely stops the virus dampening the host cells’ ability to clear it. A Monash University-led study has shown a single dose of the drug Ivermectin could stop coronavirus growing in cell culture. File image. A Monash University-led study has shown a single dose of the drug Ivermectin could stop coronavirus growing in cell culture. The next step is for scientists to determine the correct human dosage, to make sure the level used in vitro is safe for humans. “In times when we’re having a global pandemic and there isn’t an approved treatment, if we had a compound that was already available around the world then that might help people sooner,” Dr Wagstaff said. “Realistically it’s going to be a while before a vaccine is broadly available.” Before Ivermectin can be used to combat coronavirus, funding is needed to get it to pre-clinical testing and clinical trials.

 

 

https://7news.com.au...ab-c-955457.amp

 

Remember this from 2004?

 

 

Inhibition of Severe Acute Respiratory Syndrome Coronavirus Replication by Niclosamide

 

 

https://www.ncbi.nlm...cles/PMC434198/

 

 

brandname niclosamide=  ''Yomesan'' is sold out almost everywhere

 

 

 

I wonder if mebendazol and fenbendazol (both possess potent anti-tumor mechanisms) would also work.

 

 

 

 

[albedo]

In line with preventative strategies, this might be useful in the discussion with your doctor as I have it from dear friends in the north of Italy, in one of the worst hit regions. Recently the mother in law of one of them has been tested positive at 92 (also being tested for antibodies to gather insight on timing of infection) and retained in the hospital with her family not (yet) put in strict quarantine but prescribed - ONLY IF FEVER HIGHER THAN 37.5 deg C (99.5 deg F) - to take hydroxychloroquine 200mg 2x in the morning and 2x in the evening on the first day and from the second day, for at least 5 days, 1x in the morning and 1x in the evening. For the all duration MDs added azithromycin 500mg per day.

[Rosanna]

What do people here think about some use of tonic water for the quinine that's in it?  I read an article by a herbalist that mentioned trying this but that he had no idea if it would be helpful (based on the chloroquinine info...)

 

I had very mild symptoms 10 days ago of a viral infection, after 7 days isolation I took myself off out for a walk, feeling 100% fine.  The wind was very cold and I should have turned back but I didn't.  The next day I had a very bad headache, which comes and goes, a high temperature (36.8c, which is not that high, but as a hypothyroid I'm usually about 35.0c, even with thyroid treatment) and a sore throat.  There's a mild cough that seems to occur just in the evenings, usually after a temperature spike.  

 

I took elderberry until I felt better from the first round.  I felt quite strong on it as I usually do when I take it with flu etc.  But when the second round hit (and I think it's the same virus because of the shivery feeling in the legs that was there at first) I decided not to take the elderberry due to concerns about cytokine storm, but I'm continuing with echinacea.  As a previous asthmatic, so far my lungs are fine, apart from a small amount of coughing each evening after a temperature spike.  

 

Wondering now whether to try tonic water.  Wondering if because this has come back I should be concerned.  Is a second wave of it indicative of cytokine storm or just part of the pattern of this virus?  Interested in any thoughts on quinine.

[Dorian Grey]

What do people here think about some use of tonic water for the quinine that's in it?  I read an article by a herbalist that mentioned trying this but that he had no idea if it would be helpful (based on the chloroquinine info...)

 

I had very mild symptoms 10 days ago of a viral infection, after 7 days isolation I took myself off out for a walk, feeling 100% fine.  The wind was very cold and I should have turned back but I didn't.  The next day I had a very bad headache, which comes and goes, a high temperature (36.8c, which is not that high, but as a hypothyroid I'm usually about 35.0c, even with thyroid treatment) and a sore throat.  There's a mild cough that seems to occur just in the evenings, usually after a temperature spike.  

 

I took elderberry until I felt better from the first round.  I felt quite strong on it as I usually do when I take it with flu etc.  But when the second round hit (and I think it's the same virus because of the shivery feeling in the legs that was there at first) I decided not to take the elderberry due to concerns about cytokine storm, but I'm continuing with echinacea.  As a previous asthmatic, so far my lungs are fine, apart from a small amount of coughing each evening after a temperature spike.  

 

Wondering now whether to try tonic water.  Wondering if because this has come back I should be concerned.  Is a second wave of it indicative of cytokine storm or just part of the pattern of this virus?  Interested in any thoughts on quinine.

 

I'm banking on quinine from tonic water to at least have some effect.  The Chinese used old school chloroquine to treat COVID and chloroquine is actually a synthetic analog of quinine.  

 

https://en.wikipedia...iki/Chloroquine

 

"The quinoline antimalarial drug quinine was isolated from the extract in 1820, and chloroquine is an analogue of this"

 

The amount of quinine in tonic water is limited to 83mg/liter, which would provide a rather puny dose.  Doctors are dosing chloroquine at 200mg twice a day.  Might it be any help at all at preventing a mild case of COVID from progressing to end stage/advanced disease?  I haven't a clue, but hope springs eternal.  

 

Most tonic water is quite sweet, so drinking this by the liter would be a real sugar bomb.  Diet tonic water contains saccharin, which I wouldn't want in large doses either.  I've also read diet tonic is made with less quinine, so another negative for sugar free tonic water. 

 

I've found Fever-Tree "refreshingly light" Premium Indian Tonic Water in stores that has only 30 calories per 6.8oz (200ml) bottle, & have bought a dozen 4-packs of this.  I'm taking 2 bottles per night as a prophylactic and will increase to 4 bottles twice a day if I get sick.  Please note...  Caffeine & nicotine use ramps up metabolism of quinine so you might wish to avoid this.  Also...  cimetidine (brand name Tagamet) stomach remedy is known to inhibit metabolism of quinine, so a dose of this an hour or so before you dose with quinine might help it to work better.  

 

Hope you're feeling better soon!  

[DanCG]

 

 

 

Most tonic water is quite sweet, so drinking this by the liter would be a real sugar bomb.  Diet tonic water contains saccharin, which I wouldn't want in large doses either.  I've also read diet tonic is made with less quinine, so another negative for sugar free tonic water. 

 

 

Do any diet tonic waters contain aspartame? Aspartame did show up as a Potential PLpro inhibitor in one of the structure screens. That is not a chemical I wish to consume regularly, but....

[Iporuru]

Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

...Among COVID-19 patients with hypertension, those received either ARBs/ACEIs or non-ARBs/ACEIs had comparable blood pressure. However, ARBs/ACEIs group had significantly lower concentrations of CRP (p=0.049) and procalcitonin (PCT, p=0.008). Furthermore, much lower proportion of critical patients (9.3% vs 22.9%; p=0.061), and a lower death rate (4.7% vs 13.3%; p=0.216) were observed in ARBs/ACEIs group than non-ARBs/ACEIs group, although these differences failed to reach statistical significance. Our findings thus support the use of ARBs/ACEIs in COVID-19 patients with preexisting hypertension.

[Dorian Grey]

Do any diet tonic waters contain aspartame? Aspartame did show up as a Potential PLpro inhibitor in one of the structure screens. That is not a chemical I wish to consume regularly, but....

 

I've been looking at every brand of tonic water I can find over the past couple of weeks.  Haven't seen aspartame in any of them.  It's either a boat load of sugar or saccharine in the diet tonics.  Was surfing around trying to find actual quinine content without much luck, but I did find one post that said the "diet tonics" had less quinine, as the saccharine doesn't work as well as sugar against the bitterness of quinine.  

 

The Fever-Tree "refreshingly light" Premium Indian Tonic Water with "natural quinine" was the best compromise I've found.  Sweetened with fructose, but only 30 calories per 200ml bottle.  Don't know if their putting less quinine in this, but if you're going to be drinking a liter or two of tonic water per day treating acute/active COVID, you really don't want the amount of sugar you'll get from standard tonic, & I imagine the saccharine in a liter or two of diet tonic would be a pretty big dose too.  

 

A 4 pack of the Fever-Tree light would only give 120 calories (about the same as a 12 oz Coke) and may provide around 60-70mg of quinine.  Not much when you consider the chloroquine meds are dosed around 200mg twice/day, but perhaps better than nothing at all?  

Edited by Dorian Grey, 04 April 2020 - 05:19 PM.

[Rosanna]

I'm banking on quinine from tonic water to at least have some effect.  The Chinese used old school chloroquine to treat COVID and chloroquine is actually a synthetic analog of quinine.  

 

https://en.wikipedia...iki/Chloroquine

 

"The quinoline antimalarial drug quinine was isolated from the extract in 1820, and chloroquine is an analogue of this"

 

The amount of quinine in tonic water is limited to 83mg/liter, which would provide a rather puny dose.  Doctors are dosing chloroquine at 200mg twice a day.  Might it be any help at all at preventing a mild case of COVID from progressing to end stage/advanced disease?  I haven't a clue, but hope springs eternal.  

 

Most tonic water is quite sweet, so drinking this by the liter would be a real sugar bomb.  Diet tonic water contains saccharin, which I wouldn't want in large doses either.  I've also read diet tonic is made with less quinine, so another negative for sugar free tonic water. 

 

I've found Fever-Tree "refreshingly light" Premium Indian Tonic Water in stores that has only 30 calories per 6.8oz (200ml) bottle, & have bought a dozen 4-packs of this.  I'm taking 2 bottles per night as a prophylactic and will increase to 4 bottles twice a day if I get sick.  Please note...  Caffeine & nicotine use ramps up metabolism of quinine so you might wish to avoid this.  Also...  cimetidine (brand name Tagamet) stomach remedy is known to inhibit metabolism of quinine, so a dose of this an hour or so before you dose with quinine might help it to work better.  

 

Hope you're feeling better soon!  

Thanks.  I do feel better tonight.  I've just opened up one of the tonic water cans I have, took a mouthful and then decided to look up what the heck quinine actually is.  I don't like the side effects, even if they are unlikely as I get heart skips as it is, though I've been told they are benign.

 

Anyway, curiously I've got a bit of ringing in the ears which I would normally not notice, but I remembered something else the herbalist said, if you get ringing in the ears that suggests it's at a therapeutic dose.  Of course that could be coincidence in my case with one mouthful, lol.

 

Considering I'm feeling relatively ok at the moment and temperature is down for now, I'm going to just keep hold of the tonic water for if I should really need it.  Interesting though, thanks for responding.

[p75213]

"An anti-parasitic drug available throughout the world has been found to kill COVID-19 in the lab within 48 hours.

A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture."

https://7news.com.au...in-lab-c-955457

[ymc]

This vaccine patch seems very promising and can be easily deployed to millions of people:

 

https://nypost.com/2...avirus-vaccine/
 

 

[Dorian Grey]

Thanks.  I do feel better tonight.  I've just opened up one of the tonic water cans I have, took a mouthful and then decided to look up what the heck quinine actually is.  I don't like the side effects, even if they are unlikely as I get heart skips as it is, though I've been told they are benign.

 

Anyway, curiously I've got a bit of ringing in the ears which I would normally not notice, but I remembered something else the herbalist said, if you get ringing in the ears that suggests it's at a therapeutic dose.  Of course that could be coincidence in my case with one mouthful, lol.

 

Considering I'm feeling relatively ok at the moment and temperature is down for now, I'm going to just keep hold of the tonic water for if I should really need it.  Interesting though, thanks for responding.

 

Sounds like you're pretty sensitive to quinine!  Good to know if you do come down with this plague.  Hydroxychloroquine is a safer med, but still part of the quinine/chloroquine family.  Make sure to tell your doctor about your quinine sensitivity so they can watch you carefully if you are prescribed hydroxychloroquine.  

[niteinnyc]

Dorian, here is a clue about quinine content- Portland Syrups Rose City Quinine Tonic Concentrate seems to have 6 mg quinine per ounce of concentrate, as per the manufacturer's response to a question on Amazon. It has 10 grams of sugar per "serving", which is 3/4 ounce of the concentrate.

I am thinking that perhaps brewing chinchona bark into a home made tonic is a better way to go.

[Iporuru]

Fatal toxicity of chloroquine or hydroxychloroquine with metformin in mice

Guided by the principle of primum non nocere (first do no harm), we report a cautionary note on the potential fatal toxicity of chloroquine (CQ) or hydroxychloroquine (HCQ) in combination with anti-diabetic drug metformin. We observed that the combination of CQ or HCQ and metformin, which were used in our studies as potential anti-cancer drugs, killed 30-40% of mice. While our observations in mice may not translate to toxicity in humans, the reports that CQ or HCQ has anti-COVID-19 activity, the use of CQ resulting in toxicity and at least one death, and the recent Emergency Use Authorization (EUA) for CQ and HCQ by the US Food and Drug Administration (FDA) prompted our report. Here we report the lethality of CQ or HCQ in combination with metformin as a warning of its potential serious clinical toxicity. We hope that our report will be helpful to stimulate pharmacovigilance and monitoring of adverse drug reactions with the use of CQ or HCQ, particularly in combination with metformin.

[lancebr]

Interesting to see why women are not hit as hard as men with this Covid-19:

 

"Every human, male and female, carries a set of 46 chromosomes in our cells. One of those 23 chromosome pairs determines

a human’s biological sex. A man’s cells contain an X chromosome inherited from his mother and a Y chromosome provided by

his father. A woman’s cells carry two X chromosomes — one from each of her parents.

 

The X chromosome has the genes that go into making the brain and the immune system, the two crucial things you need to survive

as a human being. Both of a female’s X chromosomes are present in all her cells. But within each cell, only one of the X’s calls the shots.

Half of a woman’s cells are dominated by the X chromosome that came from her mother, half by the X contributed by her father.

That genetic diversity is really valuable.

 

One of the immune system’s most important weapons is the ability to recognize a virus. Well, genes on the X chromosome are involved

in viral recognition. Right away, women have two different populations of immune cells that are best at spotting invaders. Meanwhile, the

other X has a gene that’s very good at identifying and killing infected cells. So women’s immune cells function like a tactical unit.

They specialize, then they interact and cooperate to fight the invaders. Men, with their single X chromosome, have a far less nimble

immunological army at their command.

 

It gets worse for men in the age of COVID-19: The new coronavirus takes direct aim at their single-X vulnerability. Researchers are seeing

the way this coronavirus gets into the lung cells, and it has a key: a spike protein we think it uses to break in. The lock it picks to enter is

called ACE2 — an enzyme attached to the outer surface of the cell membrane.

 

The gene that makes ACE2 is on the X chromosome, so if the coronavirus has the right key, it can unlock every one of a male’s lung cells.

But females have two X’s — so half of their lung cells use one ACE2 lock, and the other half use a slightly different ACE2 lock. The chance

that the virus has the perfect key to unlock both of them is not great. So that’s another enormous advantage for females.

 

The virus’ lock-picking action damages the ACE2 so badly that it can no longer perform one of its crucial functions: preventing the buildup

of fluid in the lungs during the infection. It’s the lungs filling up with fluid that happens in COVID-19 that can lead to the breathing difficulties

experienced by so many. The severest lung injury we’re seeing with this infection is not likely to occur unless all your locks get picked.

In females, the virus can’t usually get into enough of their cells to do that amount of damage — and that may be the reason why we’re

seeing so many more men dying.”

Edited by lancebr, 05 April 2020 - 08:00 AM.

[mike_ag]

There's a new theory floating around, that SARS-nCov-2 impairs the ability of hemoglobin from carrying O2 in the blood.

 

https://chemrxiv.org...yrin/11938173/5

 

Some twitter threads : 

https://twitter.com/...116490614579201

https://twitter.com/...409573277282305

 

 

[albedo]

Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

...Among COVID-19 patients with hypertension, those received either ARBs/ACEIs or non-ARBs/ACEIs had comparable blood pressure. However, ARBs/ACEIs group had significantly lower concentrations of CRP (p=0.049) and procalcitonin (PCT, p=0.008). Furthermore, much lower proportion of critical patients (9.3% vs 22.9%; p=0.061), and a lower death rate (4.7% vs 13.3%; p=0.216) were observed in ARBs/ACEIs group than non-ARBs/ACEIs group, although these differences failed to reach statistical significance. Our findings thus support the use of ARBs/ACEIs in COVID-19 patients with preexisting hypertension.

 

 

Gut feeling, while waiting results of clinical trials e.g. NCT04311177 and NCT04312009, that those pushing ARBi such as the "...sartans" (eg. losartan) are on something. A nice short very recent review of the controversy here:

South, A.M., Tomlinson, L., Edmonston, D. et al. Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic. Nat Rev Nephrol (2020). https://doi.org/10.1...1581-020-0279-4

 ACEi and ARBi.png   217.01KB   0 downloads

[Rosanna]

Sounds like you're pretty sensitive to quinine!  Good to know if you do come down with this plague.  Hydroxychloroquine is a safer med, but still part of the quinine/chloroquine family.  Make sure to tell your doctor about your quinine sensitivity so they can watch you carefully if you are prescribed hydroxychloroquine.  

 

I will do thanks, it could have been a coincidence, lol, I notice everything  :-)

[lancebr]

Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension

...Among COVID-19 patients with hypertension, those received either ARBs/ACEIs or non-ARBs/ACEIs had comparable blood pressure. However, ARBs/ACEIs group had significantly lower concentrations of CRP (p=0.049) and procalcitonin (PCT, p=0.008). Furthermore, much lower proportion of critical patients (9.3% vs 22.9%; p=0.061), and a lower death rate (4.7% vs 13.3%; p=0.216) were observed in ARBs/ACEIs group than non-ARBs/ACEIs group, although these differences failed to reach statistical significance. Our findings thus support the use of ARBs/ACEIs in COVID-19 patients with preexisting hypertension.

 

 

Since ARBS/ACEIs up-regulate ACE2, then based upon this information it looks like up-regulating ACE2 is apparently the correct way to go. 

 

So keep up the Vitamin D supplementing.
 

Edited by lancebr, 05 April 2020 - 07:07 PM.

[Kalliste]

How does UVB help with immunity? By synthesising Vitamin D3? If so, is this somehow better than supplementing D3? And how do you increase your exposure? With a UVB lamp? If so, can you recommend one? Thanks.

 

There is a never ending parade of science showing that those with high solar exposure do better with a variety of disease. For centuries doctors would place patients next to open windows with a blanket.

 

I suspect that Vit D3 has become a cargo-cult, a proxy that science picks up on to reveal humans who have actually been exposed to the sun.

That means people went outside, took nice walks with their own muscles in use, maybe talked to someone and did some nice thinking while trillions of photons from the entire solar spectrum struck their exposed skin. Not just the UV-B. Also the infrared light.

 

Taking a Vit D3 pill will only give a very partial benefit of this activity.

 

I have a 300w Philips UV lamp which is very powerful, also have a Exo Terra UVB 25w E27 lamp a lot weaker which I place close to myself at work so to keep the inflow coming. Also have 2 250w Philips Infrared lamps that I light in the afternoons to simulate the sunset effect indoors.

 

If I get sick I intend to light all lamps on my balcony and lie down under a blanket on a bed in the fresh air all day if possible.

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[Kalliste]

There was a disturbing report from Russia that the asymptomatic cases can actually become infected again and fall sick. Maybe they just received a too small virus dose the first time around. Pity since I have been putting some hope in already having been afflicted by the weaker version though I had a fever. But it was probably a normal rhinovirus.

 

Dorish Loh is going all in on oral ascorbic acid as a first line defense. She goes into a fair amount of details on the molecular pathways. Provides some TL:DR graphs at the end on dosing depending on age and severity of disease.

https://www.evolutam...nd-lymphocytes/

 

The Ferritin angle is fascinating, I read somewhere ferritin will skyrocket and reach values of ~2000 in the ARDS phase. It made me do another blood donation this weekend. Going to keep up my inositol use for a while too but I am also doing Zinc so not to go too low on that if Myo inositol powder can do that.

 

This whole oxidative (and I suspect Ferroptotic) angle which seems like a big deal has made me go back to C60. I ordered a 30ml vial and took maybe 6ml so far. That effect is a very subtle one compared to MitoQ (MitoQ seems almost thorny the hour after if the two feelings are compared) the C60oo seems to affect some deeper level of function. I am able to stay clear headed and keep on working/cleaning and doing thinking without stopping up for breaks like I usually do. Or is it the placebo working me? I got this same feeling in 2015 when I first tried it and I realize now I really missed it. Hopefully it will give me some protection against the massive organ damage that seems to take place with C19 if I fall sick.

[Daniel Cooper]

Dorish Loh is going all in on oral ascorbic acid as a first line defense. She goes into a fair amount of details on the molecular pathways. Provides some TL:DR graphs at the end on dosing depending on age and severity of disease.

https://www.evolutam...nd-lymphocytes/

 

Dorish Loh is an "independent researcher" who's training is as a pianist.  Looking at her articles she apparently believes a lot of what I would consider to be fringe science.  So the fact that she's going "all in on oral ascorbic acid" doesn't exactly wow me.

 

 

 

 

 

 

 

[lancebr]

New study on use of hdroxychloroquine and azithromycin:

 

 

https://www.scienced...399077X20300858

Edited by lancebr, 06 April 2020 - 01:46 AM.

[lancebr]

There was a disturbing report from Russia that the asymptomatic cases can actually become infected again and fall sick. Maybe they just received a too small virus dose the first time around. Pity since I have been putting some hope in already having been afflicted by the weaker version though I had a fever. But it was probably a normal rhinovirus.

 

 

 

Here is a Boston doctor who says people previously discharged are coming back even sicker:

 

https://twitter.com/...830942741815300
 

[xEva]

Here is a Boston doctor who says people previously discharged are coming back even sicker:

 

https://twitter.com/...830942741815300
 

 

I think, even though he is saying they were "discharged with covid-19", he means they were sent home because their symptoms were mild.  ---  Or do you think they were "discharged" as in 'cured'?

 

Kalliste, I'd like to read that report about Russia. Do you have the link?

thanks