One condition favoring viral replication is high oxidative
stress. More ROS is produced by G6PD-knockdown cells than
their normal counterparts, and cellular GSH content was lower
than that of control cells during viral infection. The low GSH
content in G6PD-knockdown cells has been associated with low
NADPH levels in these cells. Because these changes in redox
status of G6PD-knockdown cells are associated with increased
viral gene expression (table 1), these findings are consistent with
the postulate that increased oxidative stress in G6PD-
knockdown cells promotes viral gene expression.
Because increased susceptibility of G6PD-knockdown cells to
HCoV 229E infection correlates with ROS production, antioxi-
dant pretreatment should attenuate the phenomena. Indeed, the
enhanced susceptibility of these cells to viral infection can be
attenuated by pretreating G6PD-knockdown cells with lipoic
acid (figure 1D). The current finding that lipoic acid diminishes
ROS production in G6PD-knockdown cells supports the postu-
late that oxidative stress contributes to the enhanced susceptibil-
ity of these cells to HCoV 229E infection. Moreover, this finding
also suggests that antioxidant treatment may protect G6PD-
deficient subjects from viral infection
https://www.research..._229E_infection
Antioxidants could theoretically make it worse by inhibiting the host immune response to acute viral infections, but imho that would seem to be a good idea with Covid.
Production of ROS can induce cell death and the release of virions representing possible proviral role of enhanced ROS production and altered redox balance. On the other hand, one of the important roles of oxidative stress is the triggering of an antiviral immune response. However, too strong immune responses lead to a cytokine storm and severe inflammation, which is very dangerous for tissue and may disturb lung function. From this point of view, antioxidant supplementation is expected to ameliorate the consequences of infection. Many studies showed the positive role of antioxidant therapy in infected cells and animals. At the same time, almost no relevant clinical data exist even for popular antioxidants, such as NAC, ascorbic acid, and vitamin E. This gap needs to be filled in by new research.
https://www.ncbi.nlm...les/PMC6115776/
Good overview article that briefly covers many substances we discuss. NO can be had from UV-a exposure as a DIY. I have been knocking myself out under the death rays of my 300w Philips UV lamp recently to up my Vitamin D, at the right distance (~150cm to not burn myself) it's possible to sleep almost as if you are sedated by benzodiazepines with the effects of the UV/Infra.
4.6 Nitric oxide
Nitric oxide (NO) is a gas with diverse biological activities and is produced from arginine by NO synthases. NO is able to interact with superoxide, forming peroxynitrite, which, in turn, can mediate bactericidal or cytotoxic reactions.112 In addition, NO had played an important role in regulating airway function and in treating inflammatory airway diseases.113 Rossaint et al114 reported that the beneficial effects of NO inhalation could be observed in most patients with severe acute respiratory distress syndrome. NO was also found to inhibit the synthesis of viral protein and RNA.115 Moreover, Akerström et al116 had reported that organic NO donor, S‐nitroso‐N‐acetylpenicillamine, could significantly inhibit the replication cycle of SARS‐CoV in a concentration‐dependent manner. Therefore, the NO inhalation could be also chosen as an option for the treatment of severely COVID‐19 infected patients.
https://onlinelibrar...oKrZ0Qc8MX30e6g
Dear God Help Us...
https://www.yahoo.co...-141844870.html
Trump Calls This Drug a 'Game Changer.' Doctors Aren't So Sure
"The drug (HCQ) has generated excitement because a laboratory study, with cultured cells, found that chloroquine could block the coronavirus from invading cells, which it must do to replicate and cause illness"
"A placebo-controlled trial financed by the National Institutes of Health began enrolling patients last week at Vanderbilt University Medical Center in Nashville, Tennessee. That trial aims to enroll more than 500 people who have been hospitalized"
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So their trialing a drug that "could block the coronavirus from invading cells" on patients "who have been hospitalized". Do they not realize the patients they are enrolling in this trial already have a massive viral load and the virus has already invaded the cells?
Talk about closing the barn door after the horses are already out. We live in interesting times!
Someone said he is a bull in a China shop but I remember that mythbusters tried that and the bull was pretty respectful not to touch anything.
Lucky for us places like Japan, China and South Korea are bound to try this. Japan in particular have a nice history of looking for cheap cures with open eyes so we should find out.