3083 replies to this topic

[Heisok]

Hi Calimero, I scrolled through the Dr. Alexie interview, and they show an I-MASK+ graphic indicating 1 dose every 4 weeks after the initial doses.

 

The website graphic dated 01/12/2021 shows the period as 2 weeks. Is there a newer update?

 

https://covid19criti...l-translations/

 

 

[Gal220]

Hi Calimero, I scrolled through the Dr. Alexie interview, and they show an I-MASK+ graphic indicating 1 dose every 4 weeks after the initial doses.

 

The website graphic dated 01/12/2021 shows the period as 2 weeks. Is there a newer update?

 

https://covid19criti...l-translations/

FLCC was also recommending every 4 weeks not too long ago, you are looking at the most up to date protocol

 

Edited by Gal220, 26 January 2021 - 10:06 PM.

[Gal220]

What are peoples opinion on one dose every 2 weeks?  I thought the monthly dose was ridiculous.  Presumably more than that was considered unsafe at the time?

 

Seems like 4-5 days would make more sense, again I guess they are concerned about the side effects of Ivermectin if shorter.

 

https://www.drugs.co...in-tablets.html

The plasma half-life of ivermectin in man is approximately 18 hours following oral administration.

 

 

https://www.webmd.co...bation-period#1

On average, symptoms showed up in the newly infected person about 5 days after contact.

Edited by Gal220, 27 January 2021 - 05:57 AM.

[Dorian Grey]

I'm going with bi-weekly dosing, 12mg with a fatty meal, which spikes serum levels 2.5 times higher than when taken on an empty stomach with water.  

 

https://www.accessda...0742s026lbl.pdf

 

"Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5­ fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state."

 

This (12mg dosing with fatty meal) would produce serum equivalents of around 30mg empty stomach dosing.  Serum/plasma concentrations (Cmax) largely determine the amount of uptake into tissue, so brief, high spikes should induce the greatest uptake into pulmonary tissue.  

 

Plasma half life may be only 18 hours, but IVM is taken up into tissues, where it can persist considerably longer.  Here's a paper where they dose IVM for onchocerciasis once a year: 

 

https://www.annualre...5.100191.002305

 

"The investigators concluded that a dosage of 150 u/kg, given yearly, represented the best regimen in terms of efficacy and safety."

 

It would be nice to know the half life of IVM in pulmonary tissue, but I reckon 2 weeks is a reasonable guesstimate.  

[albedo]

Open letter by Dr Kory on IVM proposed trial methodology:

Open Letter to the Investigators of the Oxford PRINCIPLE Trial on Ivermectin in COVID-19

https://bit.ly/3ccwq7b

which also re-include the evidence:

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

 

[calimero]

Hi Calimero, I scrolled through the Dr. Alexie interview, and they show an I-MASK+ graphic indicating 1 dose every 4 weeks after the initial doses.

 

The website graphic dated 01/12/2021 shows the period as 2 weeks. Is there a newer update?

 

https://covid19criti...l-translations/

 

The interview I've quoted is very recent - January 20.

In Romania, the prophylactic treatment with Ivermectin is taken every 4 weeks.

In the last 2 evenings, Dr. Alexie was invited(Skype) to a very watched show in Romania, but the treatment scheme was not discussed.

[Heisok]

Thanks calimero and Gal220

[zorba990]

In this interview ivermectin is presented both as a prophylactic and also as a late treatment. Dr. Ion Alexie was interviewed by Marius Tuca(a well-known Romanian journalist who has recovered by taking Ivermectin). Unfortunately I do not have the time to translate this interview, but in short:


Ivermectin is a very safe drug, has very few side effects, can sometimes increase transaminases and can be combined with an anticoagulant (ex: Eliquis) only if there are no contraindications. The increase in transaminases is much lower with Ivermectin compared to Remdesivir.
Dr. Alexie treated his father and brother with ivermectin and has been using ivermectin for months to treat patients in LA. The FDA has not approved Ivermectin for Covid, but the NIH approved physicians to use ivermectin.

Prophylactic treatment for a 85kg person:
- first day: 5 tablets of ivermectin (3mg / tablet) in a single dose
- third day: 5 tablets of ivermectin (3mg / tablet) in a single dose
- every 30 days (after day 3): 5 tablets of ivermectin (3mg / tablet) in a single dose

At 106kg : 1 dose = 7-8 tablets (7-8x3mg)

Early Treatment: Vitamin C + D + Zn + Ivermectin + Aspirin (or Eliquis)

Late Treatment: ivermectin + high dose of steroids (1g / day of Solu-Medrol for 3 days after which the dose is reduced according to CRP)


Dr. Alexie gargles with a solution of 1/2 hydrogen peroxide (3%) + 1/2 mouthwash. He also uses this solution for intensive care patients 3-4 times a day.
You can also do nasal washes with a solution of hydrogen peroxide (1%) and saline sterile solution.

What is the mechanism of action for Ivermectin against a virus directly?
Is there reason to believe that some strains of cover are carried by a parasite?

[calimero]

What is the mechanism of action for Ivermectin against a virus directly?
Is there reason to believe that some strains of cover are carried by a parasite?

I quote from Dr. Alexie:

"It prevents disease, but not necessarily by generating antibodies, as the vaccine does.

Ivermectin levels remain in our body for many weeks and cannot multiply in our cells.

Because Ivermectin blocks some proteins called importin, which imports fragments of the virus into the nucleus and cytoplasm and does not allow it to multiply. "

[calimero]

Nasal spray developed in Turkey kills coronavirus in 1 minute

 

Pharma & Beauty Group, will launch a nasal spray capable of removing more than 99% of the coronavirus.

Based on ionized water, known for its antimicrobial properties, this I’st class  medical device has a preventive purpose. Laurent Dodet, president of P&B, told  to AFP that this spray can be used after a person has been exposed to a risk of contracting the disease, after traveling or shopping.

The cosmetics company in Bouches-du-Rhône explains on its LinkedIn page that its spray "helps prevent the spread of viruses, remove infectious agents from the nasal cavity and facilitate their evacuation." Clinical trials conducted by the Institute of Infectious Diseases in Marseille concluded that it eliminated more than 99% of the virus in 30 seconds.

 

 

Ivermectin Nasal Spray for COVID19 Patients

 

Nasal spray formulation of ivermectin for COVID-19 shows promise in pigs

 

 

Edited by calimero, 27 January 2021 - 08:25 PM.

[Daniel Cooper]

The thing about that nasal spray - how long does it provide protection? Minutes? Hours? Days?

 

I think ivermectin is reasonably safe. But I'm not sure I want to spray it in my nose day in/day out. Your brain is right there after all. Unless that spray provides at least days of protection, I'm not sure how viable it is.  

 

I'm pretty sure that most people infected did not know the moment they were exposed after all.

 

 

[Qowpel]

Hi there.

 

I take longevity seriously and wanted an opinion from you guys on something. So basically for the last 10 years (29 now), I have partaken in intermittent fasting, prolonged periodic fasting, methionine restriction, caloric restriction optimum nutrition, and some bouts of High Intensity Interval training, to basically slow aging so that I remain young on the inside and out [if any of these even work].... At any rate, I keep my approaches to these things essentially and recently, due to the fact that I have asthma, my doctor wants me on prophylactic Ivermectin one dose of about 15 mg per week until I get vaccinated for covid due to some very promising study results on its safety as well as for seemingly being very effective at preventing infection from covid 19. So far, I have taken 3 doses. One per week as mentioned above

 

Basically he wants me to do this and I said ok kind of blindly and took my first dosage today. I did some reading and apparently it gets deposited into tissues (fat especially as it is fat soluble), and according to some studies was still detectable in significant amounts in fat tissue for like 17 days after, perhaps even longer if it was tested for..... At any rate there also was a study showing that even after a single dosage, (it is an anti parasitic an anti scabies drug being of course used off label for prophylaxis from covid 19), a small population had 90% lesser scabies in a three year period after just that single dosage and if it is potentially staying in tissue that long I wonder if that is a large problem....... So I guess I am here asking how bad this could be for longevity? Would this mean anything bad for my organs based on its ability to long term deposit into tissues especially fat? And also, would such a drug, eat up subcutaneous fat and cause a premature aging effect based on this as well as its mechanisms of action? I know this seems like a dumb question but I feel like I should ask since my doctor wants me to take this and it would be a shame if this drug were to hurt my longevity efforts to remain youthful, whether it be on the inside or the outside... Am I being silly here? At any rate here is a wikipedia page https://en.wikipedia...anism_of_action
for the drug and it has a mechanism of action section as well as a pharmikokinetics section.... I know this probably seems like the dumbest question ever. I just want to stay safe from covid, but also do not want to prematurely age myself on the inside or outside because of a drug. How long until it is fully out of the tissue in humans? Are any of my concerns reasonable or just straight up dumb?

[Dorian Grey]

Hi Qowpel, & welcome.  No worries about dumb questions here.  We're all living and learning all the time.  

 

Regarding the persistence of IVM in tissues, I was surprised to learn this just the other day. 

 

https://www.annualre...5.100191.002305

 

Apparently, for onchocerciasis a single dose once a year is all it takes.  

 

"The investigators concluded that a dosage of 150 u/kg, given yearly, represented the best regimen in terms of efficacy and safety."

 

Don't know what the long term implications are, but IVM has been around for several decades, with over a billion doses given for parasitic disease in Africa.  I'd think if there were issues with longevity, someone would have noticed.  

 

MERCK's monograph on Stromectol (their brand name for ivermectin)... 

 

https://www.merck.ca...MECTOL-PM_E.pdf

 

...doesn't have any ominous indicators I can find.  Keep in mind, many of the side effects mentioned occur due to the parasitic die-off, and in these cases the drug itself is not what is causing the symptoms.  

 

Personally, I feel the risk/reward ratio favors going with the IVM prophylaxis.  I'm 64 and in good health.  At my age, I no longer fear death like I once did, but chronic illness is now on the front burner for me.  I really don't want to have to deal with pulmonary fibrosis or cardiomyopathy the last 10-20 years of my life.  The brain fog is also a major concern, if this turns out to be chronic in some patients.  

 

Can't advise others on this decision, but it's a no-brainer for me.  I've been on IVM prophylaxis since November, without issues.  Getting out from under the coronavirus black cloud has changed my entire outlook on life.  

 

Best of Luck, & hope to see you posting again soon.  

[Gal220]

440,000 deaths later, the American Journal of Medicine has a eureka moment on HCQ.   How many lives and jobs could have been saved?  Apparently zinc is the only magical vitamin, nothing about b,c,d, and selenium.

 

COVID-19 hospitalizations and death can be reduced with outpatient treatment.

• Principles of COVID-19 outpatient care include: 1) reduction of reinoculation, 2) combination antiviral therapy, 3) immunomodulation, 4) antiplatelet/antithrombotic therapy 5) administration of oxygen, monitoring, and telemedicine.

Edited by Gal220, 29 January 2021 - 07:30 PM.

[zorba990]

An excellent and informative presentation :
Pathophysiologic Basis and Clinical Rationale for Early Ambulatory Treatment of COVID-19


Would be a great interview for Longecity

Edited by zorba990, 29 January 2021 - 09:56 PM.

[Qowpel]

Hi Qowpel, & welcome.  No worries about dumb questions here.  We're all living and learning all the time.  

 

Regarding the persistence of IVM in tissues, I was surprised to learn this just the other day. 

 

https://www.annualre...5.100191.002305

 

Apparently, for onchocerciasis a single dose once a year is all it takes.  

 

"The investigators concluded that a dosage of 150 u/kg, given yearly, represented the best regimen in terms of efficacy and safety."

 

Don't know what the long term implications are, but IVM has been around for several decades, with over a billion doses given for parasitic disease in Africa.  I'd think if there were issues with longevity, someone would have noticed.  

 

MERCK's monograph on Stromectol (their brand name for ivermectin)... 

 

https://www.merck.ca...MECTOL-PM_E.pdf

 

...doesn't have any ominous indicators I can find.  Keep in mind, many of the side effects mentioned occur due to the parasitic die-off, and in these cases the drug itself is not what is causing the symptoms.  

 

Personally, I feel the risk/reward ratio favors going with the IVM prophylaxis.  I'm 64 and in good health.  At my age, I no longer fear death like I once did, but chronic illness is now on the front burner for me.  I really don't want to have to deal with pulmonary fibrosis or cardiomyopathy the last 10-20 years of my life.  The brain fog is also a major concern, if this turns out to be chronic in some patients.  

 

Can't advise others on this decision, but it's a no-brainer for me.  I've been on IVM prophylaxis since November, without issues.  Getting out from under the coronavirus black cloud has changed my entire outlook on life.  

 

Best of Luck, & hope to see you posting again soon.  

 

Thank you so much you clearly are smarter and wiser than I am. At any rate you make a good point that I suppose people would have noticed an pro aging effects due to Ivermectin by now. So in summary, do you think based on its mechanisms of action (such as what is on its wikipedia page, as well as the fact that it seems this stuff can stay in fat tissue for so long), that this could cause organ, skin, and subcutaneous fat changes both in our body and faces, or even around our organs? Have you noticed any internal or external changes at all?

 

"Mechanism of action

Ivermectin and its related drugs act by interfering with nerve and muscle function of helminths and insects.[51] The drug binds to glutamate-gated chloride channels that are common to invertebrate nerve and muscle cells.[52] Ivermectin binding pushes these channels open, increasing the flow of chloride ions and hyper-polarizing the cell membranes.[52][51] This hyperpolarization paralyzes the affected tissue, eventually killing the invertebrate.[52] In mammals (including humans) glutamate-gated chloride channels are restricted to the brain and spinal cord; ivermectin cannot cross the blood-brain barrier and so it does not make it to the brain to affect mammalian channels.[52]"

[Dorian Grey]

I haven't noticed any changes to my facial features, but I've only been on prophylaxis around 90 days.  There's a good video here: 

 

 

that discusses a lot of possible effects.  The PAK1 & STAT3 modulation are intriguing, as this could have some effects on physiology.  

 

I was a bit wary of new medications when I was your age, & my caution has served me well.  Viagra the only pharmaceutical I've ever really embraced.  Other than that, I've just said no to drugs.  

 

Pharmageddon: A dystopian scenario wherein medicine and the pharmaceuticals industry have a net detrimental effect on human health and medical progress does more harm than good.  

 

I'm making an exception with my IVM prophylaxis.  My lungs, heart & brain are 3 of my favorite organs.  Would really feel bad if any of them got damaged.  

 

I guess there is also the option of having a stash of IVM on hand and initiating therapy at the first sign of trouble.  It really is supposed to work remarkably well when there is no delay in therapy.  You are young and should do well.  

[Qowpel]

I haven't noticed any changes to my facial features, but I've only been on prophylaxis around 90 days.  There's a good video here: 

 

 

that discusses a lot of possible effects.  The PAK1 & STAT3 modulation are intriguing, as this could have some effects on physiology.  

 

I was a bit wary of new medications when I was your age, & my caution has served me well.  Viagra the only pharmaceutical I've ever really embraced.  Other than that, I've just said no to drugs.  

 

Pharmageddon: A dystopian scenario wherein medicine and the pharmaceuticals industry have a net detrimental effect on human health and medical progress does more harm than good.  

 

I'm making an exception with my IVM prophylaxis.  My lungs, heart & brain are 3 of my favorite organs.  Would really feel bad if any of them got damaged.  

 

I guess there is also the option of having a stash of IVM on hand and initiating therapy at the first sign of trouble.  It really is supposed to work remarkably well when there is no delay in therapy.  You are young and should do well.  

 

Thanks a lot my friend. I, according the the FLCCC protocol. Took my very first dosage on January 4th (14 mg as per my boy weight), Second dose on the 6th (14 mg), and then the next dose on January 17th. What exactly would PAK1 and STAT3 modulation have in terms of body composition? I wish I was smarter when it comes to this, but I simply do not know what any of that would mean to be honest. I am going to watch the video now to try to learn more.

 

How often do you take it? It must be a giant relief to be taking a prophylactic and feeling you are protecting yourself! Youre an inspiration at your age. I hope to be like you when I get there too

[Dorian Grey]

"How often do you take it?"  Check out my post near the top of this page.  I'm dosing every other week, and only 12mg, taken with a fatty meal to enhance Cmax (serum spike level).  

 

I spent an hour or so looking into PAK1 & STAT3 issues when I first saw them mentioned, but apparently these systems are about as complicated as the immune system itself.  I never really came to any state of complete reassurance or curious alarm.  

 

Wikipedia has a couple of fairly easy reads 

Here: https://en.wikipedia.org/wiki/PAK1

And here: https://en.wikipedia...gnaling_pathway

 

Bottom line...  All pharmaceuticals probably have some risk that goes along with the reward (even Viagra causes nasal congestion, which makes me snore!). 

 

I've spent quite a few hours learning about IVM, & never really had any "oh crap" moments where I questioned the wisdom of taking it, though deep in the weeds there is much I don't understand.  

 

[Qowpel]

"How often do you take it?"  Check out my post near the top of this page.  I'm dosing every other week, and only 12mg, taken with a fatty meal to enhance Cmax (serum spike level).  

 

I spent an hour or so looking into PAK1 & STAT3 issues when I first saw them mentioned, but apparently these systems are about as complicated as the immune system itself.  I never really came to any state of complete reassurance or curious alarm.  

 

Wikipedia has a couple of fairly easy reads 

Here: https://en.wikipedia.org/wiki/PAK1

And here: https://en.wikipedia...gnaling_pathway

 

Bottom line...  All pharmaceuticals probably have some risk that goes along with the reward (even Viagra causes nasal congestion, which makes me snore!). 

 

I've spent quite a few hours learning about IVM, & never really had any "oh crap" moments where I questioned the wisdom of taking it, though deep in the weeds there is much I don't understand.  

 

Here is an interesting study. https://www.ncbi.nlm...les/PMC4029773/

 

It seems that the Jak/Stat pathway and the hormones and cytokines that activate it, are actually involved in the genesis and modulation of adipocytes. It is likely placebo, but I feel my body and face is noticeably leaner since starting Ivermectin (I have now taken 3 doses over the last 3 weeks). Perhaps it is the case i do not know. Aside from regular old subcutaneous fat though, I wonder what this also could mean for Brown fat. Fascinating paper

[lancebr]

Here is an interesting study. https://www.ncbi.nlm...les/PMC4029773/

 

It seems that the Jak/Stat pathway and the hormones and cytokines that activate it, are actually involved in the genesis and modulation of adipocytes. It is likely placebo, but I feel my body and face is noticeably leaner since starting Ivermectin (I have now taken 3 doses over the last 3 weeks). Perhaps it is the case i do not know. Aside from regular old subcutaneous fat though, I wonder what this also could mean for Brown fat. Fascinating paper

 

From all the research I have done on Ivermectin I haven't been able to find anything substantial about fat distribution and its effect on it.

 

The main concern I have had about Ivermectin is its possible neuro effects.

 

There is the following interesting article about this on pages 17 to 22 with an interesting chart.

 

http://canhgiacduoc....017-2 Final.pdf

 

 

[Qowpel]

From all the research I have done on Ivermectin I haven't been able to find anything substantial about fat distribution and its effect on it.

 

The main concern I have had about Ivermectin is its possible neuro effects.

 

There is the following interesting article about this on pages 17 to 22 with an interesting chart.

 

http://canhgiacduoc....017-2 Final.pdf

 

Thanks for sharing friend. I posted a paper in the quote you quoted me with above. If you happen to skim it and go down there is a section outlining specifically STAT3 and adipose tissue effects

[smithx]

From all the research I have done on Ivermectin I haven't been able to find anything substantial about fat distribution and its effect on it.

 

The main concern I have had about Ivermectin is its possible neuro effects.

 

There is the following interesting article about this on pages 17 to 22 with an interesting chart.

 

http://canhgiacduoc....017-2 Final.pdf

 

Very interesting. From this paper:
 

While  a  number  of   AEs  experienced  by  subjects  in  this  case  series  are  included  in  the  product  label  (dizziness,  headache,  tremor),  there  were  many other  events  which  are  similar  to  those  described  as  neurotoxic effects as found in overdose or in susceptible dogs: coma, loss of consciousness/depressed level of consciousness, abasia and coma.

 

A  number  of   cases  included  in  the  case  series  may  be  related  to  concomitantly  administered  drugs.  Drugs  that are substrates of  CYP3A4 enzymes are often also substrates for P-glycoprotein transport, and thus there may  be  a  risk  of   increased  absorption  past  the  blood-brain barrier with concomitant adminstration.9 Several cases  presented  here  reported  concomitant  use  of   such  drugs,  such  as  statins,  HIV  protease  inhibitors,  calcium   channel   blockers,   and   benzodiazepines. Current  labelling  for  ivermectin  contains  no  warning  for co-administration with CYP3A4 substrates.

 

Another  possible  explanation  is  that  some  humans  experiencing  an  SNAE  after  ivermectin  therapy  may  also  have  mutations  in  the  mdr-1  gene,  allowing  for  penetration  of   ivermectin  into  the  central  nervous  system.  More  than  50  naturally  occurring  single nucleotide polymorphisms (SNP) have been identified in  the  mdr-1  gene;  the  majority  of   these  SNP  are  silent,  and  there  is  no  current  evidence  of   a  mutation  that  results  in  loss  of   function.  However,  various  combinations   of    these   SNP,   comprising   different   P-glycoprotein haplotypes, have been found to exhibit reduced mdr-1 expression.10 Bourguinat et al performed a  study  in  which  they  analysed  mdr-1  genotypes  in  13 subjects from Cameroon: four who experienced a serious adverse event and nine who did not. Haplotypes associated  with  altered  drug  disposition  were  present  as  homozygotes  in  two  of   the  serious  AE  patients  and  in  none  of   the  control  patients.

 

 

So if you are taking any of the drugs noted above, it may be wise to be very cautious about, or avoid ivermectin.

[Qowpel]

I quote from Dr. Alexie:

"It prevents disease, but not necessarily by generating antibodies, as the vaccine does.

Ivermectin levels remain in our body for many weeks and cannot multiply in our cells.

Because Ivermectin blocks some proteins called importin, which imports fragments of the virus into the nucleus and cytoplasm and does not allow it to multiply. "

 

 

I was looking at this paper  https://parasitology...ogy_rev2009.pdf

 

In said paper, even though it is quite long, there are many mentions of it staying in liver ad fat tissue for many many days. This has me concerned with its long term effects. Especially because i can swear now that after a few oses, my bodyfat level has dropped a TON, to levels so low I literally have never seen them before. I have a very very strict diet and excercise regimen and always am with the same 1 or 2% of bodyfat year round. Right now I am sitting at a staggering 9%. Seems ivermectin not only stays in tissues (stores in fat and liver tissue with super slow excretion) long but also inhibits STAT3, which has functions in adipocyte differentiation an modulation. This has me concerned. To combat this, I have been eating 6000 calories a day to see if it reverses. y body simply is not putting the fat back on, and this is seriously conerning, especially since my last dose as of now was 14 days ago. I worry the other bodily effects it may have. And this has me wanting to stop it out of fear right now. I may just rely on quercetin plus zinc and vitamin D for prophylaxis

Edited by Qowpel, 02 February 2021 - 12:29 AM.

[Dorian Grey]

Don't know Qowpel, you could drop down to monthly maintenance, or simply have a stash on hand to start with at the first sign of illness.  

 

At your tender young age, you'll most likely have an easy time of it.  Looks like most all the young long-haulers are female.  Don't know what that's all about, but increases confidence you'll recover well.  Nothing wrong with going with your gut feeling.  I'm thinking I'll start stretching out my dosing to 3 weeks rather than 2 myself.  

 

On the other hand, Mike Osterholm says we've got a Category 5 hurricane headed our way due to the multiple new variants arriving from overseas.

 

https://www.webmd.co...hes-expert-says

 

More contagious and lethal.  Not good for an old timer like me.  Eat, drink & be merry; for tomorrow...  

[Qowpel]

Don't know Qowpel, you could drop down to monthly maintenance, or simply have a stash on hand to start with at the first sign of illness.  

 

At your tender young age, you'll most likely have an easy time of it.  Looks like most all the young long-haulers are female.  Don't know what that's all about, but increases confidence you'll recover well.  Nothing wrong with going with your gut feeling.  I'm thinking I'll start stretching out my dosing to 3 weeks rather than 2 myself.  

 

On the other hand, Mike Osterholm says we've got a Category 5 hurricane headed our way due to the multiple new variants arriving from overseas.

 

https://www.webmd.co...hes-expert-says

 

More contagious and lethal.  Not good for an old timer like me.  Eat, drink & be merry; for tomorrow...  

 

 

Thank you doriann I appreciate your input. At any rate, How is everything? Good?

 

In addition, is this new hurricane going to deem the vaccine ineffective? How disappointing. . . I can always keep it on hand and worst case I can dose a very small amount

[Dorian Grey]

At 64, I've found peace with the plague.  Worked in healthcare 35 years (surgical technologist), so I know the system well.  Can't imagine what it would be like to be dealing with this if I was younger, without knowledge of what goes on behind the hospital walls (it's not as bad as you might imagine).  

 

I've been psyching my self up about getting vaccinated, but it appears the virus mutations may well escape the vaccines by the time I am eligible.  I'm in San Diego, & they announced today around 1% of the county population has been vaccinated.  How many more mutations will occur before we even reach the half way mark?  

 

It's a fine mess...  I thank God for IVM every night.  Hard to believe it might actually work, what with the total blackout from the political scientists.  I do the best I can with the knowledge I have gleaned over the past year.  5K/day of Vitamin-D, a little zinc, & IVM.  I now live from day to day, much like I did when I was young.  Feeling fine right now, so no worries!  

 

Life is good!  

[Qowpel]

At 64, I've found peace with the plague.  Worked in healthcare 35 years (surgical technologist), so I know the system well.  Can't imagine what it would be like to be dealing with this if I was younger, without knowledge of what goes on behind the hospital walls (it's not as bad as you might imagine).  

 

I've been psyching my self up about getting vaccinated, but it appears the virus mutations may well escape the vaccines by the time I am eligible.  I'm in San Diego, & they announced today around 1% of the county population has been vaccinated.  How many more mutations will occur before we even reach the half way mark?  

 

It's a fine mess...  I thank God for IVM every night.  Hard to believe it might actually work, what with the total blackout from the political scientists.  I do the best I can with the knowledge I have gleaned over the past year.  5K/day of Vitamin-D, a little zinc, & IVM.  I now live from day to day, much like I did when I was young.  Feeling fine right now, so no worries!  

 

Life is good!  

 

Damn you sound like the grandfather i never had. So wise. Thank you Dorian!

[geo12the]

 

 

I've been psyching my self up about getting vaccinated, but it appears the virus mutations may well escape the vaccines by the time I am eligible.  

 

I don't understand why they are not actively incorporating the new variants into the vaccines. They could make a cocktail like they do every year with the flu vaccine and incorporate the UK and South African variants. They could easily include mRNAs of these spike variants into the mRNA vaccines being produced.   

[Dorian Grey]

I don't understand why they are not actively incorporating the new variants into the vaccines. They could make a cocktail like they do every year with the flu vaccine and incorporate the UK and South African variants. They could easily include mRNAs of these spike variants into the mRNA vaccines being produced.   

 

From what I've gathered, they've been making the vaccines the whole time they've been testing them so there would be no delay in massive distribution once they got approved.  

 

I read Moderna is already working on a booster, but I guess they don't want to dump everything they've produced so far, only to make people wait for the "new & improved" juice.  

 

The SARS shots may wind up needing more updates than Windows-10.