Ketamine has a wide range of uses from treating pain, anxiety, depression, and even just recreational use, who doesn't love a cozy k hole? That been said, ketamine mediates a substantial amount of its activity though antagonism of the NMDA receptors. The NMDA system is deeply involved in the buildup of tolerance to a wide range of drugs, which may be why tolerance to ketamine is said to be next to impossible to reset? With many even reporting a state of permanent tolerance that never seems to subside after prolonged high dose usage. Sarcosine is known to increase NMDA receptor activation. It is pretty effective at treating negative symptoms(apathy, depression..etc)of schizophrenia that are postulated to result from NMDA hypofunction. Perhaps it's possible to use sarcosine to restore NMDA receptor sensitivity to ketamine so tolerance can remain low? Is this something anyone has experimented with?
I myself have experimented with using sarcosine to reduce ketamine tolerance with outstanding results. I have been using sarcosine for the past 2-3 months however noticed dramatically reduced ketamine tolerance early on, just 2 weeks into it. My dose of sarcosine was 500mg daily on an empty stomach before breakfast. I must note however my results are probably not the most indicative of my suspicion that sarcosine can be used to reduce ketamine tolerance as alot of evidence does point to me suffering from pre-existing NMDA hypofunction, so perhaps sarcosine in my case has just restored brain function back to base-line so i'm more able to reap the benefits of ketamine at lower doses.
