53 replies to this topic

[Rorororo]

I don't actually know what's wrong with my brain specifically other then it's severely damaged, I have a referral for a nuero psychiatrist who hopefully can give me a better picture of what's wrong with the right brain scans.
I honestly thought Dihexa would reverse all damage and I could make a full recovery, I was even told by the most reputable source there is theoretically it should work, a one of 500mg dose has to do at least something, Iv been at this for over a decade and I'm still fucked in the head.

 

Take 7,8 DHF instead (100mg doses at a time, sublingual) 

 

How are you taking the Dihexa is the real question. Are you taking it orally, through the skin or injection?

Edited by Rorororo, 24 May 2020 - 05:56 PM.

[zorba990]

Seems some effects from ingesting the raw material(s) perhaps similarly to glucosamine.

Oral Administration of Myelin Basic Protein Is Superior to Myelin in Suppressing Established Relapsing Experimental Autoimmune Encephalomyelitis
https://pubmed.ncbi....h.gov/10229871/
"Abstract

Oral administration of a myelin component, myelin basic protein (MBP), induces immunological unresponsiveness to CNS Ags and ameliorates murine relapsing experimental autoimmune encephalomyelitis (REAE). However, a recent clinical trial in which multiple sclerosis patients were treated with repeated doses of oral myelin was unsuccessful in reducing disease exacerbations. Therefore, we directly compared the tolerizing capacity of myelin vs MBP during REAE in B10.PL mice. Oral administration of high doses of myelin, either before disease induction or during REAE, did not provide protection from disease or decrease in vitro T cell responses. In contrast, repeated oral administration of high doses of MBP suppressed established disease and MBP-specific T cell proliferation and cytokine responses. The frequency of IL-2-, IFN-gamma-, and IL-5-secreting MBP-specific T cells declined with MBP feeding, implicating anergy and/or deletion as the mechanism(s) of oral tolerance after high Ag doses. We have previously shown that the dosage and timing of Ag administration are critical parameters in oral tolerance induction. Studies presented here demonstrate that Ag homogeneity is also important, i.e., homogeneous Ag (MBP) is more effective at inducing oral tolerance than heterogeneous Ag (myelin)."

Amazon has it (Ecological Formulas - Sphingolin 200 mg 240 caps)

[FunSponge]

Take 7,8 DHF instead (100mg doses at a time, sublingual)

How are you taking the Dihexa is the real question. Are you taking it orally, through the skin or injection?

I was taking it topically but have been told by a very trusted source it's best subcutaneous in one very large dose, tried it yesterday but as I was drawing the solution it started reverting back to powder so I just freaked out added more dmso and took 500mg topically, had a ISRIB solution ready to go today but fell apart when I added olive oil, I figured it wasn't a good idea to be ingesting 99% dmso undiluted, I have the dmso stored in caps but don't know how much or if any ISRIB got dissolved, have 50mg ISRIB left, I really need need to start measuring everything before attempting any of this.

[Rorororo]

I was taking it topically but have been told by a very trusted source it's best subcutaneous in one very large dose, tried it yesterday but as I was drawing the solution it started reverting back to powder so I just freaked out added more dmso and took 500mg topically, had a ISRIB solution ready to go today but fell apart when I added olive oil, I figured it wasn't a good idea to be ingesting 99% dmso undiluted, I have the dmso stored in caps but don't know how much or if any ISRIB got dissolved, have 50mg ISRIB left, I really need need to start measuring everything before attempting any of this.

 

I.M. is ideal than subq.  I.V. if you can do it (I wouldn't by your description).   Honestly, I would wait 2 weeks (the half life is incredibly long) then just start taking 7,8 DHF from a trusted source.  Ditch the dihexa, go with something that is already proven to work.  You can always go back to it after.... You are also risking long term down regulation on the HGF module by long term use. 

 

Sure, Dihexa is strong but if it doesn't do the job properly then what is the point?  Go ditch the dihexa, ISRIB then start using 7,8 DHF.  You are just looking at EXTREME and POWERFUL solutions solely because they are EXTREME and POWERFUL. You are not looking if they can reverse the damage, the only thing that attracts you, is again, extreme and powerful. Go and try something that will work for sure (7,8 DHF)

 

If I need to tweak a microchip, I can either use tweezers or a sledge hammer.  Sure the sledge hammer is stronger and can do more but its not going to do the job I want.....

 

You see what I am saying?

 

You want the right tools for the job not just big and strong tools.... Be smart, work smart 

 

Also, how do you know your trusted source is actually trusted?  I dont mean to sound cocky, but theyre a lot of people that don't know what their talking about.  A user by the name, mentholflavoring (or something like that) suggested to use MCT oil with dihexa.... who knows where he\she got that info from but it is completely wrong, but yet he\she is acting like an expert. A non polar will dissolve a non polar but in this case do not use MCT oil with dihexa.... I am betting my money he got that from dissolving CBD or something similar... Be careful who you listen to... If people like mentholflavoring don't use actual sources then just ignore them.  There is also people that suggest stuff with the tidbit descriptions they read from articles, gamesguru is a huge culprit of this and got caught a couple of times (I have to dig but he once suggested to use modafinil for something from a short tidbit article and it turned out he was wrong....). He mainly just tries to help but still always look for reliable information. Subq isn't ideal either (its better than topical) but I.M. is the route you want.... (if you should take dihexa but in this case its not helping....)

 

Edited by Rorororo, 24 May 2020 - 11:37 PM.

[StevesPetMacaque]

I know lion's mane repairs meylin but does dihexa?

 

Yes. (It increases HGF binding to c-met, which in turn led to increased myelinization in the linked study)

[Rorororo]

Yes. (It increases HGF binding to c-met, which in turn led to increased myelinization in the linked study)

 

 

That paper stated it enhanced it's thickness not repair meylin.

 

This paper states BDNF repairs meylin:

 

https://www.ncbi.nlm...pubmed/11122329

 

Which 7,8 DHF is a BDNF promoter and directly linked to repair lead damage.

 

The reason I am stating to the complainant to use another approach is:

 

1) He has been using dihexa without much success already. 

2) Dihexa comes with psychological side effects which, without a doubt, will exacerbate his existing psychological condition

 

 

However, the complainant seems to be a little stubborn and is not following advise.  If anything, use 7,8 DHF for a period of time to reverse the lead damage then use dihexa to repair the downstream effects that followed the lead damage.  I believe the complainant is being desperate and thinking with emotion  which explains his attraction to high risk and strong tools in this case.   Which might actually work against him if its not used correctly. 

 

Please read:

 

https://www.longecit...ks/#entry722757

 

for reference on psychological side effects in laymans terms

 

Then there is a dissertation that exists that explain more detailed psychological side effects from dihexa. 

Edited by Rorororo, 30 May 2020 - 09:30 PM.

[FunSponge]

The complainant as paranoid psychosis and can't even think straight.

7.8 DHF was on my nootropic list along with cerebrolysin, I understand what your saying but I'm not stubborn, my damage is severe so yes I need the most powerful nootropics to get the job done, 7.8 dhf could work but will take much much longer and doesn't make sense when there's Dihexa.

I get my Dihexa from science.bio who seem to be one of the most trusted vendors.

I was told by probably the best authority on Dihexa ( can't reveal there identity or they might be in legal trouble) it as very low bio availability so daily 30mg doses won't do much, you need very large doses and subcutaneous works best so I will be taking 250mg for its half life every 12 day's, it was menthol flavouring who said this is just an afterglow and not its half life.

Some other silly bitch chemist told me it would be fine to inject 99% dmso with the Dihexa in it, barely a drop went in and it's like somewhat hit me with a hammer.

Menthol flavouring said you could use mct oil to dissolve Dihexa for injection?, what can be used?, maybe a 70%.dmso solution, it would be a big help if you could tell me what solvent can be injected subQ.

Not a hope I'm doing IM in my condition, subQ is easy but still very daunting to me.

I'm not ruling out 7.8 dhf or saying your wrong but I have another gram of dihexa already ordered.

Also spent the past four days injecting 5ml cerebrolysin.

I'm sure there's plenty of people trying to heal there brains after drug use but I was addicted to literally the most destructive drug experience on the face of the earth, there finally writing me a referral for a nuero psychiatrist who can hopefully diagnosis my toxic brain injury, I was told by the same source theoretically Dihexa should work for my injury and that person is an actual nuero scientist.

[Rorororo]

The complainant as paranoid psychosis and can't even think straight.

7.8 DHF was on my nootropic list along with cerebrolysin, I understand what your saying but I'm not stubborn, my damage is severe so yes I need the most powerful nootropics to get the job done, 7.8 dhf could work but will take much much longer and doesn't make sense when there's Dihexa.

I get my Dihexa from science.bio who seem to be one of the most trusted vendors.

I was told by probably the best authority on Dihexa ( can't reveal there identity or they might be in legal trouble) it as very low bio availability so daily 30mg doses won't do much, you need very large doses and subcutaneous works best so I will be taking 250mg for its half life every 12 day's, it was menthol flavouring who said this is just an afterglow and not its half life.

Some other silly bitch chemist told me it would be fine to inject 99% dmso with the Dihexa in it, barely a drop went in and it's like somewhat hit me with a hammer.

Menthol flavouring said you could use mct oil to dissolve Dihexa for injection?, what can be used?, maybe a 70%.dmso solution, it would be a big help if you could tell me what solvent can be injected subQ.

Not a hope I'm doing IM in my condition, subQ is easy but still very daunting to me.

I'm not ruling out 7.8 dhf or saying your wrong but I have another gram of dihexa already ordered.

Also spent the past four days injecting 5ml cerebrolysin.

I'm sure there's plenty of people trying to heal there brains after drug use but I was addicted to literally the most destructive drug experience on the face of the earth, there finally writing me a referral for a nuero psychiatrist who can hopefully diagnosis my toxic brain injury, I was told by the same source theoretically Dihexa should work for my injury and that person is an actual nuero scientist.

 

Silly bitch chemist?  I no longer want to help you.  These people are trying to help you yet you're only listening to someone giving you potential wrong advice. Hopefully you will listen to the nueropsychiatrist.  

Edited by Rorororo, 31 May 2020 - 07:10 PM.

[FunSponge]

A nuero psychiatrist at best will probably be only able to diagnose with the proper brain scans, I don't think there are any nuerogenic drugs they can prescribe in my country.

Maybe drop the attitude, I never said you were wrong but why would I take the advice of some random person online probably with no training when an actual nuero scientist says Dihexa should work.

Actually Rohoro will you kindly fuck off out of this tread, your ego seems more important then actually wanting to help.

Edited by FunSponge, 31 May 2020 - 07:28 PM.

[Rorororo]

A nuero psychiatrist at best will probably be only able to diagnose with the proper brain scans, I don't think there are any nuerogenic drugs they can prescribe in my country.

Maybe drop the attitude, I never said you were wrong but why would I take the advice of some random person online probably with no training when an actual nuero scientist says Dihexa should work.

Actually Rohoro will you kindly fuck off out of this tread, your ego seems more important then actually wanting to help.

 

Sure, I already said I was going to.  

 

P.S. you spelt my username wrong.

 

Good luck  

Edited by Rorororo, 31 May 2020 - 08:44 PM.

[FunSponge]

Your a fucking rude ass hole and anyone else reading this thread would probably agree, yes I spelled your name wrong, I have psychosis you fucking dumb shit.

[Rorororo]

Your a fucking rude ass hole and anyone else reading this thread would probably agree, yes I spelled your name wrong, I have psychosis you fucking dumb shit.

 

I know you do.  Yet, you have been attacking people trying to help you and are listening to a neuroscientist(?) that is potentially giving you bad advice.  I then told you something that is proven to work alongside proof that you're going to make your symptoms worse with Dihexa, and you attacked me.  Who sounds like the dumb shit?

Edited by Rorororo, 31 May 2020 - 09:15 PM.

[FunSponge]

You are a fucking idiot, I attacked no one, you have been nothing but rude and obnoxious and not in the least bit helpful, what in Christ makes you qualified to be giving medical advice over a nuero scientist?, now your just making thing's up to win a pissing contest to save face, I asked you nicely to fuck off, please stop replying, stop trying to get the last word with your stupid fucking smiley face.

Go jump on someone else's thread with your year's of training in bio chemistry, your expertise is just been wasted here when you have the power to help so many others.

Hopefully there's a block button, I don't want to hear any more from you.

[Rorororo]

You are a fucking idiot, I attacked no one, you have been nothing but rude and obnoxious 

 

Mmmmm, lets back track a bit ( a few moments ago):

 

 

 

Some other silly bitch chemist

 

 

 

of some random person online probably with no training when an actual nuero scientist says Dihexa should work.

 

 

Actually Rohoro will you kindly fuck off out of this tread, your ego seems more important then actually wanting to help.

 

 

Your a fucking rude ass hole and anyone else reading this thread would probably agree, yes I spelled your name wrong, I have psychosis you fucking dumb shit.

 

 

Now this...

 

 

 

and not in the least bit helpful, , 
Go jump on someone else's thread with your year's of training in bio chemistry, your expertise is just been wasted here when you have the power to help so many others.

 

I literally told you what will fix you and told you what you are taking will make your symptoms worse.  I also provided proof and evidence to back it up.  If this isn't helping, I don't know what is. 

 

 

what in Christ makes you qualified to be giving medical advice over a nuero scientist?

 

First of all, I don't think you were talking to an actual neuroscientist.  Also, you are making an argument that is trying to appeal to authority and not facts. It doesn't matter what my 'qualifications' are.  I can say absolutely anything or have absolutely everything but if the facts don't line up, then its useless. 

 

 

 

now your just making thing's up to win a pissing contest to save face, I asked you nicely to fuck off, please stop replying, stop trying to get the last word with your stupid fucking smiley face.

 

 

Edited by Rorororo, 31 May 2020 - 10:30 PM.

[FunSponge]

I only attacked you after you were been rude, obnoxious and behaving like a fucking ass hole, you deserved to be attacked, I have severe tissue damage from injecting 99% dmso on the advice that chemist gave me and when I sent her a photo of the tissue damage she gave it a like so that's why I called her a silly bitch.

You don't want to look bad on an anonymous internet form as this seems to be the only way you can get any validation in life so your trying to win an argument with absolutely no rationality because you were already in the wrong.

Yes I actually did receive correspondence from a nuero scientist who is currently testing Dihexa in human trials, you have no qualifications in this field and have the nerve to think you know better, alot of people on this forum talk like there experts but have never studied it in school, I was been polite at first, I said I didn't think you were wrong and I asked you to drop the attitude but you kept behaving like a fucking ass hole so I told you to fuck off.

I think I already came across you on reddit nootropics unless that was just another fucking ass hole, I can't block you and your spamming my thread trying to protect your precious ego.

Please please please fuck off out of my thread, I actually have serious medical issues I'm trying to fix and don't have time for dick heads like you.

[Rorororo]

I only attacked you after you were been rude, obnoxious and behaving like a fucking ass hole, you deserved to be attacked, I have severe tissue damage from injecting 99% dmso on the advice that chemist gave me and when I sent her a photo of the tissue damage she gave it a like so that's why I called her a silly bitch.

You don't want to look bad on an anonymous internet form as this seems to be the only way you can get any validation in life so your trying to win an argument with absolutely no rationality because you were already in the wrong.

Yes I actually did receive correspondence from a nuero scientist who is currently testing Dihexa in human trials, you have no qualifications in this field and have the nerve to think you know better, alot of people on this forum talk like there experts but have never studied it in school, I was been polite at first, I said I didn't think you were wrong and I asked you to drop the attitude but you kept behaving like a fucking ass hole so I told you to fuck off.

I think I already came across you on reddit nootropics unless that was just another fucking ass hole, I can't block you and your spamming my thread trying to protect your precious ego.

Please please please fuck off out of my thread, I actually have serious medical issues I'm trying to fix and don't have time for dick heads like you.

 

Look man,I know you have serious medical issues.  I am legitimately trying to help.  If someone, anyone, disagrees with you then you think they're wrong.  That wasn't me on reddit. That guy and I do not care if you follow our advice.  If I came in saying yeah, keep doing these drugs (that wont work) then, without a doubt, you would listen.  Anyone that opposes you is incorrect and your listening to someone doing human trials(?).  I honestly do not think you're in contact with them. If you are, then I doubt they are who they are saying they are. 

 

Dihexa - will make your symptoms worse.  I honestly think it will dig you from a bigger hole and I have valid reasons for it. 

ISRIB - is no use for you and wont even work at this point. 

HA - FGL - seems to increase glutamate (IIRC) which will cause excitotoxicity. This explains why the rats tested lost portions of their brains.  Also, an increase in glutamate will, without a doubt, make your symptoms worse. 

 

You need to increase your BDNF, repair meylin then once your psyche is fixed then you can consider making new synapses with dihexa. Otherwise, your just telling your brain to mold faster in your current stance (to put it in laymans terms). 

 

Think of you brain like play-doh.  It is moldable.  Dihexa makes the play-doh wet, making it super moldable.  I first have the play-doh in a certain shape (prior to your gasoline).  Then during and after the gasoline, the play doh got molded a certain shape BUT it slightly resembles the original shape. It's possible to recreate the original shape.  However, I put dihexa in the play-doh, make it wet, so its super moldable.  I then mold it further AWAY from the shape after the gasoline.  It now looks less like the original shape and the original shape will be harder to get back to.

 

Now, I could do this.  I have the play-doh after the gasoline, then I start putting the correct clay (BDNF) inside it.  The clay fixes the shape (as it is proven with the articles I gave you).  It is now looking the original shape but its a little weak.  I then make the play-doh wet with dihexa then it reinforces the shape and makes it strong again.

 

The choice is yours.  Realize how much time I spent writing this out to someone arguing with me.  I am trying to help you.  Take my advice and get back on your feet in a couple of weeks or keep digging my friend.  If you genuinely want help, then DM me.  I will help you further there, personally and tailored help. Also, realize I am not a registered doctor so any advice I give, shouldn't be taken as medical advice but for theoretical purposes. I am sure you came in with presumption already.  As you came to the internet for help, after all.  Not only the internet, but a site tailored towards research topics, LOL. Also, I don't even know if gasoline damages meylin to be honest.  I never had to study it. I just took your word for it. If you are serious and want help, I can look more into it for you. I just ask that you realize I am here to help and anything that I tell you (for research purposes) will be backed up by direct evidence that I find. I research, I don't practice medicine. That is all I can do. 

Edited by Rorororo, 01 June 2020 - 03:23 PM.

[FunSponge]

Look man, you are straight up just an ass hole who's now trying to play nice to further save face, you weren't legitimately trying to help you were been an obnoxious little prick, not once did I say you were wrong, I don't care if you don't believe I'm in touch with this person, I don't make shit up to win arguments.
Maybe work on yourself as a person and try to be more respectful in the future if you want more positive interactions, whatever you choose is up to you but please stay off this thread.

[Rorororo]

Look man, you are straight up just an ass hole who's now trying to play nice to further save face, you weren't legitimately trying to help you were been an obnoxious little prick, not once did I say you were wrong, I don't care if you don't believe I'm in touch with this person, I don't make shit up to win arguments.
Maybe work on yourself as a person and try to be more respectful in the future if you want more positive interactions, whatever you choose is up to you but please stay off this thread.

 

 

My advice to you is take a day or two (without any Research Chemicals) then think about this and our interaction.  

[FunSponge]

Took 250mg Wensday, was going to dose weekly but due to desperation and really bad suffering these past few days I took another 250mg today, my condition would drive anyone to suicide and I'm close to eating a bullet right now despite the fact I have no access to a hand gun.

The only time I'm not suffering from psychosis is when I'm asleep, it's the only escape I have in life, I wake up completely at peace, feeling good and happy and then in an instant the psychosis start's and I'm back to been sick and demented.

Spent my entire 20's suffering from severe depression, I would have done anything to cure it and now I haven't had depression in year's but I'm still suffering severe psychosis so I'm still going through psychiatric hell daily.

I don't know what human being deserves this, pre huffing everything in my life couldn't have been better, addicted to the most destructive drug experience on earth and no one even fucking noticed let alone helped get me of it and literally decade's of isolation and psychiatric illness ever since.

I'm taking omega 3 fish oil and vitamin b complex, it's meant to provide the building blocks for Dihexa to work off, I'm doing everything I can to get better but fuck me I'm still suffering really badly and I don't know if this even is curable.

[Rorororo]

Took 250mg Wensday, was going to dose weekly but due to desperation and really bad suffering these past few days I took another 250mg today, my condition would drive anyone to suicide and I'm close to eating a bullet right now despite the fact I have no access to a hand gun.

The only time I'm not suffering from psychosis is when I'm asleep, it's the only escape I have in life, I wake up completely at peace, feeling good and happy and then in an instant the psychosis start's and I'm back to been sick and demented.

Spent my entire 20's suffering from severe depression, I would have done anything to cure it and now I haven't had depression in year's but I'm still suffering severe psychosis so I'm still going through psychiatric hell daily.

I don't know what human being deserves this, pre huffing everything in my life couldn't have been better, addicted to the most destructive drug experience on earth and no one even fucking noticed let alone helped get me of it and literally decade's of isolation and psychiatric illness ever since.

I'm taking omega 3 fish oil and vitamin b complex, it's meant to provide the building blocks for Dihexa to work off, I'm doing everything I can to get better but fuck me I'm still suffering really badly and I don't know if this even is curable.

 

 

You should get on anti-psychotics.  Try and ask your doctor about these.  

[FunSponge]

Iv been on anti psychotics for years they don't do anything for this, I'm literally fucking loosing it and going to go stay in a psych ward.

[Rorororo]

Iv been on anti psychotics for years they don't do anything for this, I'm literally fucking loosing it and going to go stay in a psych ward.

 

 

You should really stop the dihexa, read the post I linked.  It makes things worse, read the 'symptoms' it stated. 

[FunSponge]

I was already suffering long before Dihexa, there's no way in hell it could be making me worse, it might well be working but it's not an instant magical fix, I'm in no shape to be arguing about Dihexa, I'm seriously just going to go stay at a psych ward it's probably what's best for me.

[Rorororo]

I was already suffering long before Dihexa, there's no way in hell it could be making me worse, it might well be working but it's not an instant magical fix, I'm in no shape to be arguing about Dihexa, I'm seriously just going to go stay at a psych ward it's probably what's best for me.

 

 

Try and go to one that is more advanced.  They will know more about your condition and how to treat you.  I am sure you will be back on your feet in a matter of weeks.