What spermidine supplement do you take?
My (extensive and expensive?) regimen
#31
Posted 25 April 2023 - 07:56 PM
#32
Posted 25 April 2023 - 10:51 PM
What spermidine supplement do you take?
DoNotAge
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#33
Posted 28 April 2023 - 12:49 PM
Another update, some removals and some newish additions
Male, aged 53
On waking
A scoop of Collagen Peptides, one tablespoon Cacao and 2.5 grams Creatine in a black coffee
With breakfast
Zinc Picolinate 15 mg
Nicotinamide Riboside 350 mg
Urolithin A 250 mg
Ubiquinol 100 mg
Hyaluronic acid 200 mg
Alpha Ketoglutaric acid 300 mg
Fish Oil 1000 mg (685mg EPA 310mg DHA)
N-Acetyl Cysteine 600 mg
Dinner
Fish Oil 1000 mg (685mg EPA 310mg DHA)
Vitamin D3 2000iu
Tocotrienols 125mg (Delta & Gamma)
Vitamin K2 90mg
Lycopene 15 mg
Lutein 20mg & Zeaxanthin 4mg
Astaxanthin 6 mg
Alpha Ketoglutaric acid 300mg
Spermidine 8mg
Urolithin A 250 mg
Apigenin 50mg
Night
Magnesium Glycinate 200mg
Glycine 1000mg
Probiotic (20 strains, 65 billion CFU's)
Nice stack, similar to my own. Why don't you add senolytics to it such as quercetin or better yet fisetin?
And what about metformin/acarbose?
Additionally, why did you stop taking Rutin?
Edited by forever freedom, 28 April 2023 - 01:03 PM.
#34
Posted 30 April 2023 - 04:32 PM
Nice stack, similar to my own. Why don't you add senolytics to it such as quercetin or better yet fisetin?
And what about metformin/acarbose?
Additionally, why did you stop taking Rutin?
I am considering senolytics - but just haven't got around to the research yet.
I have no idea if Metformin is a good idea or not? and I stopped Rutin due to some tendon soreness every time I took it
I added an Ergothioneine supplement, Whey protein isolate, a multivitamin and a sublingual B12 (due to lowish blood test levels). Also doubled my NAC intake to 1200 mg per day
Male, aged 53
On waking
A scoop of Collagen Peptides, one tablespoon Cacao and 2.5 grams Creatine in a black coffee
With breakfast
Zinc Picolinate 15 mg
Nicotinamide Riboside 350 mg
Urolithin A 250 mg
Ubiquinol 100 mg
Hyaluronic acid 200 mg
Alpha Ketoglutaric acid 300 mg
Fish Oil 1000 mg (685mg EPA 310mg DHA)
N-Acetyl Cysteine 600 mg
Multivitamin
Lunch
Whey protein isolate
Sublingual B12 Methylcobalamin
Dinner
Fish Oil 1000 mg (685mg EPA 310mg DHA)
Vitamin D3 2000iu
Tocotrienols 125mg (Delta & Gamma)
Vitamin K2 90mg
Lycopene 15 mg
Lutein 20mg & Zeaxanthin 4mg
Astaxanthin 6 mg
Alpha Ketoglutaric acid 300mg
Spermidine 8mg
Urolithin A 250 mg
Apigenin (Liposomal) 50mg
Ergothioneine 5mg
Night
Magnesium Glycinate 200mg
Glycine 1000mg
NAC 600mg
Probiotic (20 strains, 65 billion CFU's)
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#35
Posted 26 May 2023 - 06:54 PM
You can get that 50mg quercetin with an inconsequential amount of dried parsley I think? 1-2 tablespoons? I think 1g of dried parsley has like 40-50mg apigenin which is so much cheaper of a route to go than the supplements online.
RE Taurine (Needs references, but I haven't got time. These are easy to verify with Google)
- Taurine inhibits PARP-1
- Excessive PARP-1 uses up cytosolic NAD+.
- Inhibiting PARP-1 can restore cytosolic NAD+ with amazing immediate benefits
- But PARP-1 participates in DNA repair
- Inhibiting PARP-1 with Taurine will reduce DNA repair.
- DNA repair is one of the main activities of cells occurring many times per second
- When DNA repair lags behind DNA damage, the DNA damage will accumulate
- I will not personally inhibit PARP on purpose (Rutin also inhibits PARP)
- Taking TRU Niagen and Grape Seed Extract likely has your cytosolic NAD+ levels good without Taurine
Re Apigenin
- Nuclear CD38 is the main consumer of nuclear NAD+ in old age
- Apigenin with Quercetin inhibits nuclear CD38 and will restore nucNAD+ in old age
- Without nuclear NAD+ there is no benefit from boosting SIRT1
- Apigenin 50mg/day will build up to a steady state level of about 300mg due to its long half life. This is sufficient
- Quercetin inhibits DNA polymerases (POLS) which are used to make DNA & RNA.
- Quercetin has a very short half life. So taken once daily in normal dose (250-500mg) it will not inhibit POLS very long. However I would not take it multiple times per day
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