8 replies to this topic

[Believer]

A Hypoxanthine deriviative is under development for increasing nerve growth factor and treating neurodegenerative diseases. However it seems Hypoxanthine itself has an ability to stimulate nerve growth or nerve growth.

 

Hypoxanthine riboside, also known as inosine.

I want to try inosine for brain health, nerve growth.

Has anyone tried it yet?

[Believer]

I tried inosine today, 2 grams orally.

It gives a very odd tingling feeling in all my nerves in my body, exactly the feeling I get when I overdose on anti-estrogen medication.

It does provide energy, just like carnitine and other supplements do.
it seems to sharpen some of my senses like nerve growth factor does, however it lacks some of the effects I associated with nerve growth factor increases like memory enhancement, clarity of mind, vastly improved sense of smell and other things.

 

I tried intranasal but did not see much of a difference between oral and intranasal, probably because it very easily crosses the BBB and is active in the brain.

[Daniel Cooper]

Looks interesting. Where did you get it from?

 

 

 

 

[Believer]

Looks interesting. Where did you get it from?

Inosine is a dietary supplement easily purchased from most major supplements websites. I bought from amazon.co.uk

I haven't tried the patented drug neotrofin yet but am looking to try it if it really does what it says it does.
I suspect it's actually because they can't patent inosine they changed the molecule to make a drug out of it.

I will trial inosine in my father who had the brain bleeding and lack of ability to move  half of his body. we'll see what happens. Hoping for the best.

 

[Daniel Cooper]

 

I suspect it's actually because they can't patent inosine they changed the molecule to make a drug out of it.
 

 

I suspect you're probably exactly right.

 

The model for much of drug development these days is to find some exiting natural compound that provides some positive effect.  Then tweak the molecule such that it becomes patentable regardless if whether the tweak makes it work somewhat better or somewhat worse.

 

It's hard to look at the pharmaceutical industry very hard without becoming somewhat jaded.

[Believer]

I suspect you're probably exactly right.

 

The model for much of drug development these days is to find some exiting natural compound that provides some positive effect.  Then tweak the molecule such that it becomes patentable regardless if whether the tweak makes it work somewhat better or somewhat worse.

 

It's hard to look at the pharmaceutical industry very hard without becoming somewhat jaded.

 

As forums like these have proven, many medical problems can be cured or treated very easily without expensive drugs but evidently we're not allowed to solve problems.

I think politically there is an attempt to prevent the treating of various disorders that can kill people or limit their life.

 

At least if they simply slightly alter a natural chemical and patent it, the chance's that it's toxic to people is a lot lower than if they invent some chemical structure never seen in nature.

 

[sedentary]

i read about it, and this is what i got; After ingestion, inosine is metabolized into uric acid, which has been suggested to be a natural antioxidant and peroxynitrite scavenger with potential benefits to patients with multiple sclerosis"

 

so basically it raises uric acid. and from other studies on it, they correlate its benefits with uric acid in all of them. and as usual problem with high uric acid levels, kidney stones were an issue.

now i have a question, why not raise uric acid using a lot of other things? A LOT of things raise uric acid. if you benefit from extra raise of uric acid, you might be low OR genetically predisposed. im not sure i need to buy some supplement made in china to raise uric acid when i can find many other things.

[Believer]

i read about it, and this is what i got; After ingestion, inosine is metabolized into uric acid, which has been suggested to be a natural antioxidant and peroxynitrite scavenger with potential benefits to patients with multiple sclerosis"

I did try intranasal, which produced the exact same effects as oral ingestion.
If it is metabolized by the liver into uric acid then intranasal should surely have different effects but it does not.

Inosine does a whole lot more than what uric acid does. Inosine raises energy and endurance levels.

What is it they do when they want to reduce a supplement's breakdown, add an acetyl group? Shouldn't be too difficult to make acetyl-inosine?
 

[sedentary]

it seems isopronisonine is antiviral; https://www.amazon.c...82913915&sr=8-7

also this one; https://www.amazon.c...0S5XSGXA4MFT7X8