45 replies to this topic

[ryukenden]

Hi all

I am thinking to take some supplements to reduce the chance of getting Covid 19 or Corona virus. Which supplements do you recommend?
 

I read in a news that Curcumin has some antiviral action against Coronavirus. Are you aware of anything else?

 

https://www.indiawes...0267c416fd.html

[Hebbeh]

https://www.longecit...om-coronavirus/

[kurdishfella]

yogurt or kefir larger quantities must be enjoyed, daily. it will help your immune system fight it off.

[experimenting]

Lactoferrin is a good start. Indicated against viruses, cheap, low side effects.

[maxwatt]

Resveratrol has potential as an IL-6 inhibitor. However, it's not been tested. The Chinese screened a number of substances, including polydatin which is the glycine of resveratrol which has similar metabolic effects. However they found chloroquine more effective at shortening the course if the illness. Possible prophylactic?

[geo12the]

I was just made aware of this article which suggests rapamycin:

 

 

https://www.nature.c...PTXr7Lr9FczW87Q

 

"Sirolimus (Z = –2.35 and GSEA score = 3), an inhibitor of mammalian target of rapamycin (mTOR), was reported to effectively block viral protein expression and virion release effectively50. Indeed, the latest study revealed the clinical application: sirolimus reduced MERS-CoV infection by over 60%51. Moreover, sirolimus usage in managing patients with severe H1N1 pneumonia and acute respiratory failure can improve those patients’ prognosis significantly50 "

[MrCrispr]

This just came out today:

 

FDA Grants Bellerophon Emergency Expanded Access for INOpulse® for the Treatment of COVID-19 Virus

WARREN, N.J., March 20, 2020 (GLOBE NEWSWIRE) -- Bellerophon Therapeutics, Inc. (Nasdaq: BLPH) (“Bellerophon” or the “Company”), a clinical-stage biotherapeutics company, today announced that the U.S. Food and Drug Administration (FDA) has granted emergency expanded access allowing its proprietary inhaled nitric oxide (iNO) delivery system, INOpulse®, to immediately be used for the treatment of COVID-19

 

I'm wondering if supplements used to improve NO would be a positive adjunct to others used to improve the immune system.  Others such as Neo40, L-Arginine (especially L-Arginine + Arona berry extract), etc.

[zorba990]

Interesting since high blood pressure is listed as a risk factor for complications. Could be related to compromised NO generation. Agmatine plus citrulline plus glutathione should fix that.

https://www.ncbi.nlm...les/PMC4472409/

[hamishm00]

Beta Glucans.

http://https://www.e...-infection.html

 

https://www.ergo-log...-infection.html

 

http://https://www.e...infections.html

 

[BioHacker=Life]

Right now chloroquine is the only clinically studied drug shown to be effective in COVID-19. I stocked up and suggest anyone do the same. It's a cheap drug and easy to acquire.

 

 

Quote

Biosci Trends. 2020 Mar 16;14(1):72-73. doi: 10.5582/bst.2020.01047. Epub 2020 Feb 19.

Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies.

 

Abstract

The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future.

 

https://www.jstage.j...7/_pdf/-char/en

 

[MrCrispr]

 

Right now chloroquine is the only clinically studied drug shown to be effective in COVID-19. I stocked up and suggest anyone do the same. It's a cheap drug and easy to acquire.

 

 

Quote

 

 

I thought Plaquenil required a prescription?  Not sure I would trust, especially at these times, a third party seller.
 

[BioHacker=Life]

I thought Plaquenil required a prescription?  Not sure I would trust, especially at these times, a third party seller.
 

 

You can get it from any pharmacy in the US. Do you not trust licensed pharmacies? If so I guess you don't believe in doctors or pharmacists. Not sure what to say to that. But good luck with your echinacea and snake oil.

[sthira]

You can get it from any pharmacy in the US. Do you not trust licensed pharmacies? If so I guess you don't believe in doctors or pharmacists. Not sure what to say to that. But good luck with your echinacea and snake oil.

So you went to your doctor, asked for, received a prescription for chloroquine, and then had it filled at a pharmacy?

[BioHacker=Life]

So you went to your doctor, asked for, received a prescription for chloroquine, and then had it filled at a pharmacy?

 

Do you get your prescription drugs another way? Yes I went to my health clinic and their doctor gave me a script. Went to CVS and got my supply. You people seem confused about how prescriptions work. Are you outside the US?

 

A lot of doctors are writing themselves or their patients scripts now in case there's a massive run on the drug and it becomes very expensive or unavailable. I rather have it now than when every pharmacy and hospital is out of it if I get sick.

 

 

Edited by BioHacker=Life, 22 March 2020 - 12:53 AM.

[sthira]

A lot of doctors are writing themselves or their patients scripts now in case there's a massive run on the drug and it becomes very expensive or unavailable. I rather have it now than when every pharmacy and hospital is out of it if I get sick.

A lot of doctors are doing this? Really? Do you personally know a lot of doctors who are writing their patients chloroquine prescriptions as a preventative measure against coronavirus, or do you have a reference to share with us?

[BioHacker=Life]

A lot of doctors are doing this? Really? Do you personally know a lot of doctors who are writing their patients chloroquine prescriptions as a preventative measure against coronavirus, or do you have a reference to share with us?

 

Yes alot of doctors will off label prescribe drugs to patients. It's very a common practice. Like gabapentin for sleep or anxiety. Also see ahrq.gov/patients-consumers/patient-involvement/off-label-drug-usage.html.  Twitter has been reporting this for the past few days for both hydroxychloroquine and chloroquine.

 

I don't offhand know anyone prescribing it as a preventive it's meant to be taken if you have COVID-19. It's not a drug you want to take everyday.

 

Sure there's 2 lists of cutting edge doctors you can use LEF or A4M.

 

https://health.lifee...ovativedoctors/

 

https://www.a4m.com/find-a-doctor.html

 

I found my clinic and current doctor through here when I was looking for HGH and Testosterone for anti aging benefits. You can find a doctor near you in most states. If you have a long term doctor they can easily write you a script offlabel.

Edited by BioHacker=Life, 22 March 2020 - 01:08 AM.

[sthira]

Thanks, BioHacker, that’s interesting information.

[BioHacker=Life]

Thanks, BioHacker, that’s interesting information.

 

During medical outbreaks many rich or informed people stockup on vital drugs and basic supplies in advance. It's why they aren't like most people who by the time they got to the store had nothing in stock are desperate for tp. I'm really surprised most people are taking COVID-19 lightly. People are literally dying every few minutes from this.

[MrCrispr]

,

 

You like to jump to conclusions and are eager to respond with sarcasm.  It's obvious that others here understood what the the meaning of my question was, therefore I see no need to explain it to you. Well, good for you that you have a doctor that will give you an Rx for Plaquenil, HGH and Testosterone.  Perhaps you are overdosing on the latter since you display such aggressive language.  For your information, most doctors, as many here realize, will not prescribe medication "off label".  Even many pharmacies will not fill prescriptions for doctors for their own use.  Yes, I know quite a bit about what can and can not be prescribed.  I write them everyday in my practice.  Immature idiot.

 

Edited by MrCrispr, 22 March 2020 - 05:12 AM.

[Harkijn]

Here in the Netherlands IC doctors since very recently are allowed to use chloroquine or hydroxychloroquine, but only in extreme cases because of the safety doubts. Today their first impressions became public: they are not very impressed sofar. Also they report: depression, vomiting and strain on heart function as sides.

It's very early days and the patients are exclusively the most serious cases so this may skew the picture.

[kurdishfella]

testosterone will worsen your immune system that's why women have better immune system since they react faster to infections but with testosterone you react slower.

IGF-1/2 can probably help the immune system also along with hgh.

[BioHacker=Life]

,

 

You like to jump to conclusions and are eager to respond with sarcasm.  It's obvious that others here understood what the the meaning of my question was, therefore I see no need to explain it to you. Well, good for you that you have a doctor that will give you an Rx for Plaquenil, HGH and Testosterone.  Perhaps you are overdosing on the latter since you display such aggressive language.  For your information, most doctors, as many here realize, will not prescribe medication "off label".  Even many pharmacies will not fill prescriptions for doctors for their own use.  Yes, I know quite a bit about what can and can not be prescribed.  I write them everyday in my practice.  Immature idiot.

 

I cite facts and experience. You think doctors don't prescribe offlabel? Clearly you know nothing of doctors or their practices. Or the research on drugs for other conditions. Anyone can google offlabel prescriptions and come to their own conclusions. Here is my cited source. 

 

 

 

 Off-label prescribing is common; it accounts for 10 to 20 percent of all prescriptions written.

 

http://www.aafp.org/...t?pmid=24444499

 

 

Doctors write each other scripts it's very common but not done very often. Usually insurance is not involved to avoid being flagged.

 

You really should read and learn about things before you talk about them. Ignorant much? So you now claim to be a doctor and are telling people what other doctors do without so much as a google or pubmed search or any experience working with other doctors? Wow I would have to seriously question your intelligence on anything. 

 

Many patients are treatment resistant and do not respond to drugs FDA approved for their condition. Those patients are given other FDA approved drugs when research supports its use in those conditions. This is common knowledge by healthcare professionals and the FDA.

 

https://www.fda.gov/...ved-drugs-label

 

 

You may be asking yourself why your healthcare provider would want to prescribe a drug to treat a disease or medical condition that the drug is not approved for.  One reason is that there might not be an approved drug to treat your disease or medical condition.  Another is that you may have tried all approved treatments without seeing any benefits.  In situations like these, you and your healthcare provider may talk about using an approved drug for an unapproved use to treat your disease or medical condition.

 

 

You are not a doctor. You are a fraud. You've only been a member here for 4 days and suddenly you're a M.D. Post any proof of your claim. 

Edited by BioHacker=Life, 22 March 2020 - 04:01 PM.

[BioHacker=Life]

Here in the Netherlands IC doctors since very recently are allowed to use chloroquine or hydroxychloroquine, but only in extreme cases because of the safety doubts. Today their first impressions became public: they are not very impressed sofar. Also they report: depression, vomiting and strain on heart function as sides.

It's very early days and the patients are exclusively the most serious cases so this may skew the picture.

 

Cite your source. Otherwise this is pure bs.

 

I'm citing a controlled study and it was found to be effective for all cases not just serious cases tested without serious side effects in most. Yet you're claiming the exact opposite? Hell this drug is taken daily for years by many US patients with arthritis.

 

https://t.co/J7ZdKICmM5?amp=1

Edited by BioHacker=Life, 22 March 2020 - 03:32 PM.

[Harkijn]

Cite your source. Otherwise this is pure bs.

 

 

You sound a bit overheated. Hope you don't run a fever?

 

I do not need to quote any source since I don't take any special position, don't want to make a scientific point just offering some info from a place where corona is already a reality not a debating point...

However, to satisfy you here is a link from a national paper which you can run through Google translate. If you are really interested....

https://www.ad.nl/bi...ingen~a21b9548/

[BioHacker=Life]

You sound a bit overheated. Hope you don't run a fever?

 

I do not need to quote any source since I don't take any special position, don't want to make a scientific point just offering some info from a place where corona is already a reality not a debating point...

However, to satisfy you here is a link from a national paper which you can run through Google translate. If you are really interested....

https://www.ad.nl/bi...ingen~a21b9548/

 

Alot of people are making false claims during a worldwide crisis where people are dying so yes I take that very seriously as anyone should.

 

If you are making a medical claim you should have facts to back it up. Anything thinking otherwise either is a idiot, a fraud or has their own agenda.

 

I'll read this tabloid and reply shortly but I would take clinical research over a news article with selected unconfirmed quotes any day as any intelligent person would.

Edited by BioHacker=Life, 22 March 2020 - 04:36 PM.

[BioHacker=Life]

Alot of issues with this article.

 

Whether people in the Netherlands have been saved with this drug? "You can't say that, we don't know much about it yet," admits the foreman. Moreover, he emphasizes: "Of course you don't know what would have happened to those people if you had not used the drug."

 

 

 

So they admit they have no idea at this point.

 

The guideline recommends that specialists use the controversial products only in patients with 'serious complaints' and when people are in mortal danger. Yesterday, doctors spoke via video conference about the guideline: "Unfortunately, the burden of proof for the substances mentioned in the guideline is wafer-thin," acknowledges Van den Toorn. “That is why there is continuous consultation, many patients keep track of what the treatment has been and we try to become wiser in the end. In the meantime, we are also waiting for the results of studies that are still ongoing. Only it will take a while before the results come in: that will not happen in a week. ''

 

So they are using the drug only when the patient is near death? Sounds very smart and a great way to determine how effective it is.....

 

In addition to chloroquine, there is also another malaria drug 'hydroxychloroquine', "It resembles chloroquine and is also used in some hospitals," says Van den Toorn. And then there is the virus inhibitor 'remdesivir'. This medicine was originally used against the extremely deadly disease Ebola, but was dropped because other medicines were found to work better. According to Van den Toorn, it is hardly prescribed in the Netherlands, because it is very poorly available. '

 

 

Sounds like they don't even have any or much to really evaluate it. 

 

 

So they are giving it to dying patients only as a last resort and have no idea if it's working or not since they are already near death and no one is reviewing cases as you would in a clinical trial so we could compare placebo to treatment.

 

Yeah I'm not going to base anything on this example. Just hearsay and few facts.

[BioHacker=Life]

Here in the Netherlands IC doctors since very recently are allowed to use chloroquine or hydroxychloroquine, but only in extreme cases because of the safety doubts. Today their first impressions became public: they are not very impressed sofar. Also they report: depression, vomiting and strain on heart function as sides.

It's very early days and the patients are exclusively the most serious cases so this may skew the picture.

 

Ok now that I read your tabloid piece.

 

You stated they are allowed to use it only in extreme cases because of safety issues.

 

When in fact they have supply issues with the drugs and are only giving it to dying or near death patients. Because it's safer in dying patients? OK...

 

You stated they reported depression, vomiting, and strain on heart function.

 

When in regards to this drug they only reported 

 

"But at least patients suffer from side effects, such as depressive complaints, nausea and vomiting."

 

 

I would be depressed too if I was dying of COVID-19.

 

Your last statement is the only one I find accurate.

 

Now did you read the actual clinical study published in China on the drug and what are your thoughts on that? Or do you solely use tabloids as your source of medical knowledge?

Edited by BioHacker=Life, 22 March 2020 - 04:43 PM.

[BioHacker=Life]

Even the CDC has confirmed doctors are offlabel prescribing drugs for COVID-19 patients.

 

https://www.cdc.gov/...ic-options.html

 

some U.S. clinicians have reported anecdotally different hydroxychloroquine dosing such as: 400mg BID on day one, then daily for 5 days; 400 mg BID on day one, then 200mg BID for 4 days; 600 mg BID on day one, then 400mg daily on days 2-5.

 

 

Why? Because there is no approved treatment for COVID-19...

[BioHacker=Life]

,

 

For your information, most doctors, as many here realize, will not prescribe medication "off label".  Even many pharmacies will not fill prescriptions for doctors for their own use.  Yes, I know quite a bit about what can and can not be prescribed.  I write them everyday in my practice.  Immature idiot.

 

Doctors Are Hoarding Unproven Coronavirus Medicine by Writing Prescriptions for Themselves and Their Families

https://www.propubli...-their-families

 

You know nothing and apparently don't even read the news. I really don't get how grossly ignorant some people are when all the facts are clearly showing otherwise.

Edited by BioHacker=Life, 24 March 2020 - 05:03 PM.

[osris]

The attached article says that the drugs nelfinavir and lopinavir will treat Covid-19.

 

 preprints202003.0226.v1.pdf   1MB   11 downloads