31 replies to this topic

[Turnbuckle]

 

In any case, the bioavailability of ursolic acid is very low, at around 1%. So although you get around 50 mg of ursolic acid in an apple peel, very little is actually absorbed, which may be a good thing if there are DNA damage issues.

 

 

 

 

The melting point of UA is very high -- 285 to 288 °C -- and it's very hydrophobic, thus the solubility in water is low. Possibly the Venezuelans have modified it to be more hydrophilic and thus more soluble. UA is reasonably soluble in warm ethanol -- 5 mg/ml -- so one ounce of pure ethanol could dissolve 140 mg of UA. This could then be mixed into olive oil to keep it from craping out. UA's solubility in DMSO is about 5 times higher. 

Edited by Turnbuckle, 27 October 2020 - 06:45 PM.

[EliotH]

This article might be of interest here. There is a discussion of mitochondrial fission and fusion modulation.

 

https://www.frontier...020.614650/full

 

Impact of COVID-19 on Mitochondrial-Based Immunity in Aging and Age-Related Diseases

 

Edit:

 

It also mentions

 

Mitochondrial ROS then stimulates additional proinflammatory cytokine production (Li et al., 2013) as the virus continues to persist, eventually leading to a “cytokine storm” in which over-inflammation can cause fatal harm if adaptive immunity does not take over in time.

 

 

Turnbuckle mentions that stearic acid might slow down the virus giving the immune system time to react in #3 in the OP.

Edited by EliotH, 18 April 2021 - 03:27 PM.