37 replies to this topic

[FunSponge]

I'm taking nac to balance glutamate / gaba, with Dihexa you need very large doses as it has low bio availability.

You said to look into pcp recovery well supposedly HA - FGL can reverse the damage caused by pcp, I don't know how closely linked pcp and solvent abuse are but hopefully it can work for both.

[wallheck]

Side effects of the FGL peptide do exist. In young rats on high doses (around 100mg Human equivalent dose) every other day for two weeks, huge brain loss was found, despite improving memory. The dosage was high, higher than other studies, and personally is a bizarre dosage to choose. This widespread apoptosis was completely blocked when administered with Amyloid plaques, a well-known cause and consequence of the Alzheimer’s pathology. It seems that these plaques interfere with apoptosis.

Interesting and terrifying.

 

Super interesting! The first thing that this reminded me of is neural pruning, which is crucial to learning/development. Loss of structure isn't always bad. Note there's a difference between neural pruning and apoptosis:

 

https://www.ncbi.nlm...les/PMC6503856/

 

 

 

During nervous system development neurons are produced in excess to ensure productive connections are made to the appropriate targets. Neurons that are unable to successfully innervate their targets, or are no longer necessary, are selectively eliminated by the activation of the apoptotic pathway.

 

I wonder if the apoptosis with NA-FGL is selective! Did the mice run into significant problems with the brain loss? It seems like this could be really beneficial at the sweet spot for efficiency.

 

Also maybe it'd open up the potential for neural reprogramming with combinations drugs that 1) promote nerve growth factors/neurogenesis and 2) promote transcription factors that determine cell fate. I.e., take NA-FGL to reduce useless neurons, then take NSI-189 to promote neuron growth (there's definitely a better drug than this, as this would be mostly hippocampus growth AFAIK) alongside 9-Me-BC (dopaminergic transcription factors). Boom, much higher density of dopamine neurons than before. 

 

Very speculative, need to do more research on NA-FGL's apoptosis for sure. 

Edited by wallheck, 18 July 2020 - 09:11 PM.

[FunSponge]

https://www.ncbi.nlm...les/PMC3840324/

Another study linking psychosis to blocking of the NMDA receptor and an imbalance of gaba / glutamate, they used pcp to deliberately block NMDA receptors to induce psychosis,Rohorro you weren't wrong when you said to research reversing damage from pcp, solvent abuse also blocks the NMDA receptor.

Iv been taking nac and glycine for over a month now to regulate glutamate / gaba and unlock the NMDA receptor, I feel I'm making progress, still not cured though.

I have access to HA - FGL but it's not cheap, it's sold as just 1mg, anyone know if 1mg is enough to be effective?

[Rorororo]

https://www.ncbi.nlm...les/PMC3840324/

Another study linking psychosis to blocking of the NMDA receptor and an imbalance of gaba / glutamate, they used pcp to deliberately block NMDA receptors to induce psychosis,Rohorro you weren't wrong when you said to research reversing damage from pcp, solvent abuse also blocks the NMDA receptor.

Iv been taking nac and glycine for over a month now to regulate glutamate / gaba and unlock the NMDA receptor, I feel I'm making progress, still not cured though.

I have access to HA - FGL but it's not cheap, it's sold as just 1mg, anyone know if 1mg is enough to be effective?

 

 

Sweet!  Now I have convinced you that I know what I am talking about.  I want you to take gastrodin.

 

Please look:

https://www.ncbi.nlm...les/PMC3137192/

 

I did a quick google search and found it in europe.

 

I think the company was x-nootropics. 

 

Or, a lot of tian ma will do the trick (which is more accessible).

 

 

Once the psychosis is done and over, I want you to message me and we will start working on repairing your brain.

Edited by Rorororo, 30 July 2020 - 03:06 PM.

[FunSponge]

Don't get too exited, I never said you knew what you were talking about just you weren't wrong when you said look up how to reverse pcp damage, you never mentioned a mdma receptor or a gaba / glutamate imbalance, this is still just theory without the convenience of a brain biopsy, ill probably never know what the fuck is wrong with me but I do know Iv gotten more success with a month of nac and glyceine then six months of Dihexa.

[Rorororo]

Don't get too exited, I never said you knew what you were talking about just you weren't wrong when you said look up how to reverse pcp damage, you never mentioned a mdma receptor or a gaba / glutamate imbalance, this is still just theory without the convenience of a brain biopsy, ill probably never know what the fuck is wrong with me but I do know Iv gotten more success with a month of nac and glyceine then six months of Dihexa.

 

Well, yes.....

 

Dihexa isn't going to do anything for you (as I kept telling you).

 

 

You should really look into gastrodin.....

[gintrux]

Well, yes.....

 

Dihexa isn't going to do anything for you (as I kept telling you).

 

 

You should really look into gastrodin.....

I just accidentally stumbled upon gastrodin yesterday but was unable to find a vendor. Actually every eager to try it. LifeExtension looks like discontinued their product. Do you know any other vendor? x-nootropics.com out of stock.

[Rorororo]

I just accidentally stumbled upon gastrodin yesterday but was unable to find a vendor. Actually every eager to try it. LifeExtension looks like discontinued their product. Do you know any other vendor? x-nootropics.com out of stock.

 

 

No, sorry.  https://www.alibaba.com/ probably has it though.