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P A Y W A L L E D S O U R C E : Mechanisms of Ageing and Development
Highlights
• Review of the nature of aging physiology in the skin.
• Summary of recent findings to uncover the molecular origins of aging in the skin.
• A look forward to potential rejuvenative interventions based on previous studies.
Abstract
Perhaps the most recognizable consequences of tissue aging are manifest in the skin. Hair graying and loss, telltale wrinkles, and age spots are indicative of physiological aging symptoms, many of which are analogous to processes in other tissues as well with less visible outcomes. While the study of skin aging has been conducted for decades, more recent work has illuminated many of the fundamental molecular and physiological causes of aging in the skin. Recent technological advances have allowed for the detection and quantification of a variety of physiological triggers that lead to aging in the skin and molecular methods have begun to determine the etiology of these phenotypic features. This review will attempt to summarize recent work in this area and provide some speculation about the next wave of studies.
Outline
1. Hallmark phenotypes of aging in skin
1.1. Thinning of skin
1.2. Thinning hair
1.3. Hair graying
1.4. Increased susceptibility to cancer
2. The cell biology of skin aging
2.1. DNA damage
2.2. Stem cell exhaustion
2.3. Wound Healing Defects
2.4. Circadian rhythm
2.5. Mitochondrial mutations
2.6. Cell competition and Senescence
3. Conclusion
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