3 replies to this topic

[Targz]

Recently, an orally active drug with the same MOA as Dihexa, NDX-1017, got approved for a phase II/III clinical trial. Interested to see where this goes.

 

https://www.biospace...inancing-round/

 

I can't find much about it, not even a structure. Anyone else able to find anything?

[megatron]

Where did you get it's orally active? In the phase 1 clinical trial they delivered the drug via subcutaneous injections.  

 

From the page linked above: "Athira Pharma was founded to commercialize the technology, and further development (of Dihexa) led to NDX-1017" 

[Targz]

Where did you get it's orally active? In the phase 1 clinical trial they delivered the drug via subcutaneous injections.  

 

From the page linked above: "Athira Pharma was founded to commercialize the technology, and further development (of Dihexa) led to NDX-1017" 

 

My bad, but in their pipeline they do have a drug referred to as "2nd generation NDX" (which is likely very similar to NDX-1017) that's orally active. Not quite sure how I missed that...

Edited by Targz, 28 July 2020 - 03:41 AM.

[William Sterog]

Very interesting.