2 replies to this topic

[TMNMK]

I have a question for folks who take PQQ and vitamin C.

 

I've noticed that PQQ is reduced by vitamin C:

 

Pyrroloquinoline quinone (PQQ) is reduced to pyrroloquinoline quinol (PQQH2) by vitamin C, and PQQH2 produced is recycled to PQQ by air oxidation in buffer solution at pH 7.4

https://pubmed.ncbi....h.gov/26264520/

 

And in the study:

 

Pyrroloquinoline quinone inhibits the production of inflammatory cytokines via the SIRT1/NF-κB signal pathway in weaned piglet jejunum

https://pubs.rsc.org...0/fo/c9fo02609f

 

it states "... however, the addition of 200 mg kg−1 VC to the diet containing PQQ reduced most of the effects of PQQ" and "... higher concentrations of VC react with PQQ, which inhibits the regulatory mechanism of PQQ." in the abstract.

 

So my question is whether there is concern by those taking PQQ simultaneously with vitamin C that perhaps they are negating some of the potential positive effects of PQQ by its reduction with vitamin C? If there is not concern, why not?

Edited by TMNMK, 19 September 2020 - 03:20 AM.

[Oakman]

The 1st linked study says VC helps PQQ, 

 

"As reported in the previous studies, PQQ coexists with α-TocH in foods and biological systems (such as plasma, blood, and various tissues).2,19,20,22) Consequently, the above-mentioned synergistic effects, Table 3. Changes in the absorbance of PQQH2 at 307.5 nm due to the reaction of PQQH2 with air (molecular oxygen) in the buffer solution (pH 7.4) at 25.0 °C.   ... Recycling of PQQH2 and PQQ under the coexistence of Vit C 185 i.e., an increase in the free-radical scavenging rate and the suppression of the pro-oxidant reaction may also function in foods and biological systems. Recently, in light of its beneficial physiological effects, PQQ has been identified as a potential candidate for its use in the dietary supplements.47) The results obtained in the present study suggest that the use of supplements including PQQNa2, Vit C, and α-TocH at the same time is preferable in maintaining a good health."

 

As to the 2nd lined study, the amt of VC is quite a lot, even for a pig. If "mg kg−1" means 200mg/kg then for a 70kg person, 200 mg x 70 or 14 grams of Vitamin C. That's a lot.

 

"However, the addition of 200 mg kg−1 VC to the diet containing PQQ reduced most of the effects of PQQ. We further show that PQQ reduced (P < 0.05) the expression of inflammation-related genes (IL-2, IL-6, TNF-α, and COX-2) via the SIRT1/NF-κB deacetylation signaling. In conclusion, our data reveals that PQQ exerts a certain protective effect on the intestines of piglets, but higher concentrations of VC react with PQQ, which inhibits the regulatory mechanism of PQQ."

 

Overall, I'd say normal VC and PQQ intake is complementary, and doesn't cancel each other. Just an opinion, I'd need to see studies, but at 1st glance anyway...

 

[TMNMK]

Ah, excellent, thank you Oakman. Good eye, thank you for pointing that out!