38 replies to this topic

[Perry23]

Nice to hear that. I read a lot about supplementation and there are a lot out there, most of them probably are some bullshit some of them are good. But one of the few supplements that I have huge trust after reading a lot in recent years is just melatonin, and it is the only supplement that I take almost 8 years. Now I take 750mcg long release Live Extension - seems to be the best from which I have try. For years I have learn that more not always is better, long release for me much better and over 1mg seems to worse my sleep but under even 300mcg works great . For sure melatonin is more of a supplement not to get sleep but to sleep deeper and better,if you are stressed if your cortisol is high, malotonin don't help too much, phosphatidylserine seems to help in getting sleep.

[Thingsvarious]

Thingsvarious,

 

Would you like to try large doses of melatonin for the regeneration of the thymus?

 

https://pubmed.ncbi....h.gov/12880677/

 

 Analyzing various studies, I conclude that even at a young age it makes sense to already start to engage in its regeneration. 

 

Recently, it was found that aging cells of the immune system appear to be potentially some of the most damaging of all senescent cells, as they spread tissue damage and rapid aging to other organs and systems of the body:

https://www.nia.nih....hout-aging-body

 

Personlly, I would not under any circumstance take high doses of melatonin (everything above 3mg/d), mainly because of the way melatonin regulates the other hypothalamic hormones (reduces all of them but GH)

[Thingsvarious]

Update:

 

I have now been off the GH and the cortisol for 5 months. I just got my blood results.

After weaing off GH and cortisol, these two axes are now at higher levels than they were before. On this weeks blood test ACTH was at the 85th percentile (very pulsatile so take it with a grain of salt), cortisol at the 75rth percentile, and IGF1 at around the 75th percentile as well.

 

This shows that -at least for me- replacing these axes with a full replacement dose for a few years did not cause any sort of permanent downregulation (and in fact, my hormones are now higher compared to where they were before -whether this is due to lifestyle changes or whether hormone treatment increased my setpoint for these hormones I do not know).

[Kentavr]

Update:

I have now been off the GH and the cortisol for 5 months. I just got my blood results.
After weaing off GH and cortisol, these two axes are now at higher levels than they were before. On this weeks blood test ACTH was at the 85th percentile (very pulsatile so take it with a grain of salt), cortisol at the 75rth percentile, and IGF1 at around the 75th percentile as well.

This shows that -at least for me- replacing these axes with a full replacement dose for a few years did not cause any sort of permanent downregulation (and in fact, my hormones are now higher compared to where they were before -whether this is due to lifestyle changes or whether hormone treatment increased my setpoint for these hormones I do not know).

Many animal studies show that higher growth hormone levels are associated with lower maximum life expectancy. You keep your growth hormone at a very high level. What do you think about this?

[Thingsvarious]

Many animal studies show that higher growth hormone levels are associated with lower maximum life expectancy. You keep your growth hormone at a very high level. What do you think about this?

 

Data regarding GH/IGF1 is very conflicting. Read my thoughts on whether GH prolongs or shortens lifespan HERE

[Thingsvarious]

Many people keep emailing me how to best test for cortisol. Well, thats complicated. Generally, cortisol is incredibly hard to test for. I have seen an elevated cortisol many times in total cortisol, but often CBG is high. Generally, a good indicator of adrenal health is DHEA-S. Other than that, in my experience, urinary and salivary cortisol are not worth much. The best may simply be a trial and error of a small dose of HC (e.g. 5mg). If you strongly feel it, you may assume that cortisol is low. If you feel nothing, then cortisol is likely not your problem. Read more about this topic at hormetheus.com/cortisol

 

[Thingsvarious]

Update: Now I have been off all the hormones for some time (the last I stopped was thyroid). LH and TSH are normal again, IGF-1 slightly elevated and cortisol at the 60th percentile. So, whatever the cause, it seems that I have more than recovered from 2 years of complete hormone replacement. Though, I used a special protocol to wean off involving some neuropharmaceuticals to kickstart things again.

 

However, if I again in the future need to hop back on hormone treatment, I am willing to do so as the benefits can be life-changing

[Thingsvarious]

Update: After replacing my thyroid for 3 years, I have been off any thyroid meds now for 4 weeks. Blood test revealed a TSH of 1.8 and a fT4 at the top of the reference range and a fT3 at the bottom - so it seems that at least my hypothalamus has perfectly recovered. The most important "ingredient" has been semaglutide (Ozempic)

[Galaxyshock]

What's next? Replace all your endorphins with opiates?

 

Sounds like unnecessary and possibly even dangerous route to start doing these things, especially in young adulthood.