Submitted for your approval... A very deep dive into mRNA vaccines with a German Cellular Biologist.
http://enformtk.u-ai...chmidt_krueger/
Interview with Dr. Vanessa Schmidt-Kruger / Hearing # 37 of German Corona Extra-Parliamentary Inquiry Committee 30 January, 2021
I initially started skimming through this and became totally transfixed. Not your typical conspiracy rant. Attached a pdf, & here are a few excerpts to peak your curiosity.
*VSK: I’m a cell biologist and my specialist field is the functional characterisation and elucidation of proteins, i.e., I understand how proteins are produced, how they are transported in the cell, how they are taken up by cells, how they are metabolised, how intra- and intercellular communication takes place, including within tissue, and how organs interact. This is all very important if one wishes to conduct a risk assessment: how the vaccine functions for example, and the dangers/risks of the lipid nanoparticles (LNPs). This technology is not really new: it’s novel as a vaccine, but we have been using these LNPs in research for over 20 years, and we have always been struggling with the problem of toxicity of the lipids and balancing this against their efficacy.
The first point is that the BioNTech vaccine that is currently already being used is not highly purified, it contains contaminants of certain components. The problem that BioNTech had is that in the clinical phase the product, i.e. the RNA, was produced with completely different techniques to how it is being produced now. During the clinical phase they only needed small volumes of vaccine, they were able to use very expensive techniques that delivered highly purified end products. Now that they have entered mass production, that is no longer possible, they have had to switch to lower-cost processes.
t the RNA is transcribed from the DNA and then the DNA has to be eliminated, it is digested by enzymes: by DNAses. And if this DNA is not digested well enough, if residues are left, this harbours risks. BioNTech has admitted that there are DNA contaminants.
It was found that the integrity of the RNA always varies in the batches that had been made. So – the integrity of the RNA means of course the RNA quality. They have found that this is not very high: it was higher for the processes during the clinical phase. they have found new batches with only 55% RNA integrity, i.e., half of it is basically unviable.
VSK: To come back to Ms. Fischer’s question about the DNA. The problem is that when it contains DNA contaminants, then the situation is: well, with RNA it is relatively unlikely that it can integrate into the host’s cell nucleus. The situation is different with DNA, and especially in this case because you have contaminants of linearised DNA.
the lipid nanoparticles get into all cells, not just the muscle cells – it is an error to believe the latter
So it is theoretically possible that this linearised DNA that is in there as a contaminant could integrate into the host’s cell nucleus in a dividing cell, linearised DNA is optimal for integration.
The vaccine itself, even if the DNA – that contamination – were not in it – is still a genetic intervention.
there are further contaminants, there is double-stranded RNA for instance. The EMA Committee says it is slight, it is acceptable
There are also contaminants with regard to the lipids (30.32). There are two new lipids, they have focused on them. One is ALC-0315, that is the cationic lipid, and the other is ALC-0159, the PEGylated peptide, the PEG component. And they have found that the end product – that there are contaminants in the end product in some batches.
The technology of the nanoparticles. I don’t want to completely malign it. It’s a superb technology really. But the problem is that it is still much too early for use in human beings. The toxicity is still too high, that first needs to be eliminated, then it would really be a brilliant technology. There are many scientists working on getting rid of this toxicity, research has been conducted on that for years.
the LNPs consist of up to 50% of these cationic lipids: 50% is very high, they are toxic because they have this positive charge. This enables them to enter into interactions with other components of the cell really well, they can also basically interact with negatively charged amino acids. This destroys the proteins which lose their ability to function because they “unfold” as it is called. In principle they can interact with the DNA because the DNA is also negatively charged due to its phosphate groups, creating DNA strand breaks. They can also interact with other lipids because they are also negatively charged, especially the lipids of the cell membrane. E.g. the cell membrane of the mitochondria. If however these cationic lipids gain entry, it is confirmed in many publications that they destroy this membrane, and this leads to the formation of a large number of oxygen radicals. These oxygen radicals create a lot of damage in the cell. They interact – they alter the amino acids, the cell pours out as many cytokines as it can, the oxygen radicals also attack membranes and create lipid peroxidation.
The questions that arise before something like this comes onto the market are how long it remains in the body, divided up as follows: how long do the lipids remain, How long does the mRNA remain? How are they broken down? What is their distribution in the body?
So what is the distribution of the lipid nanoparticles (LNPs) in the animal trial? They injected the whole muscle and watched how the lipids spread out throughout the body, and found that these lipids were in many organs after just 15 minutes. They found evidence of the cationic lipid in the plasma for 12 days, and evidence of the PEG lipid for 6 days. So they remained for quite some time. The cationic lipids are exclusively degraded in the cells, only 1% was found in the stool. This means the cells take the full hit of the toxicity. One can still find 5% of the lipid in the liver after 4 - 6 weeks – that is incredibly long.
cationic lipids have a half life of 20 to 30 days in human beings, and the elimination to 5%, so not really eliminated, takes 4 - 5 months. That’s a long time.
So why exactly is the liver being damaged? It’s because the liver is the organ that takes up the most lipoproteins. And why does it take up the most? Because one of its functions is to break down cholesterol; I’ve explained that the nanoparticles are bound to ApoE proteins. These make their way directly back to the liver where the cholesterol is broken down, and that’s why the liver comes into contact with a huge amount of this. With the mice or rats, the damage disappears after 3 weeks: does some small damage remain in the liver, or does it regenerate completely? VSK: Yes, it regenerates completely. The liver is fairly robust.
Long-term studies and studies on possible autoimmune conditions were not conducted.
This mechanism crosses the blood-brain barrier due to the ApoE -mediated transport. So the LNPs can cause damage in the brain.
RF: How long does one need to hold one’s breath when one has been vaccinated. A lifetime, or does there come a time when you can relax again? VSK: It depends on which damage you are observing. The lipids are there for 4 - 5 months. Damage can arise for as long as the lipids are there.
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Don't know about you, but I'm hunting down the J&J jab!
