8 replies to this topic

[sub7]

https://www.prnewswi...-301179606.html

"Company Expands Leadership Team as it Advances Preclinical Studies of rGDF11 in Stroke and Other Age-Related Diseases"

 

This is the company with which Amy Wagers (the discoverer of GDF-11) is involved. In the press release they say: 

 

"We are focused now on advancing our first drug, rGDF11 toward the clinic both to promote recovery after stroke and to treat obesity.  The expansion of our executive team and the additions to our board of directors will help to guide Elevian as we enhance our understanding of aging and age-related diseases."

 

but how will they patent GDF-11? Will they simply demonstrate efficacy of GDF-11 for specific applications and then obtain a use-patent, such that they will be the only ones who can use GDF-11 for, let's say, recovery from stroke, while the molecule GDF-11 itself will be unpatentable? 

The r in front of GDF-11 in the press release stands for "recombinant" which simply refers to how they manufacture it.

[QuestforLife]

Agree, this is not a 'drug' as they claim, so can't be patented in that way. I see similar arguments with E5. 

[ortcloud]

Agree, this is not a 'drug' as they claim, so can't be patented in that way. I see similar arguments with E5. 

 

Same goes for Katchers much hyped "blue gel" which is just GHK-cu.

 

I think they are going to try to get creative with the patent in an effort to get some IP.

[rodentman]

I thought they were producing a drug that would be a pre-cursor for GDF11, so it would be easier to administer?

 

If the 'r' just stands for recombinant, that doesn't really denote much of anything.   Pretty much all GDF11 that is available is recombinant in one way or another.

[ortcloud]

I thought they were producing a drug that would be a pre-cursor for GDF11, so it would be easier to administer?

 

If the 'r' just stands for recombinant, that doesn't really denote much of anything.   Pretty much all GDF11 that is available is recombinant in one way or another.

 

They were going to but I think they abandoned that idea if I recalll in some press release.

 

It will be interesting to see what their dose is, because I have been taking gdf11 for 2 years and the dose is really tricky

and has an unusual dosing approach.

[QuestforLife]

It will be interesting to see what their dose is, because I have been taking gdf11 for 2 years and the dose is really tricky

and has an unusual dosing approach.

 

I agree. I've been taking it for almost a year and you do have to calibrate the dose. I am guessing this is because of the similarity of GDF11 to GDF8 (Myostatin); if you take too much GDF11 you might trigger the myostatin receptors. 

 

I noticed increased inflammation at the site of old injuries when my (cumulative) GDF11 dose got too high. This seems to be in agreement with myostatin inhibition reducing circulating cytokines. 

 

 

 Myostatin inhibition suppressed the levels of circulating inflammatory cytokines including TNF-α and IL-6. In exploring the influence of myostatin on these cytokines, we found that TNF-α stimulates myostatin expression in muscle cells, whereas myostatin stimulates IL-6 production. These responses provide support for the hypothesis that inflammation causes the CKD (Chronic kidney disease)-induced loss of muscle mass (21). Our results suggest that inhibition of myostatin might reverse muscle atrophy associated with CKD and possibly other catabolic conditions that share characteristics of CKD. Source: doi: 10.1096/fj.10-176917

Edited by QuestforLife, 03 November 2021 - 01:32 PM.

[ortcloud]

I agree. I've been taking it for almost a year and you do have to calibrate the dose. I am guessing this is because of the similarity of GDF11 to GDF8 (Myostatin); if you take too much GDF11 you might trigger the myostatin receptors. 

 

I noticed increased inflammation at the site of old injuries when my (cumulative) GDF11 dose got too high. This seems to be in agreement with myostatin inhibition reducing circulating cytokines. 

 

Interesting. How much were you taking?

 

I take smaller doses than Steve Perry recommends. I took 75pg daily until I hit the wall or downregulate as steve would say.

 

My body just feels better and things have healed. To me, its the closest thing you can get to stem cell infusions.

[Kentavr]

Interesting. How much were you taking?

 

I take smaller doses than Steve Perry recommends. I took 75pg daily until I hit the wall or downregulate as steve would say.

 

My body just feels better and things have healed. To me, its the closest thing you can get to stem cell infusions.

 

Where did you order the GDF11?

[ortcloud]

bucky labs