36 replies to this topic

[Castiel]

 

 

1.  I don't understand why you regularly take melatonin.  How old are you that you think your own endogenous melatonin production is so diminished that you need to replace it with supplementation?  I can understand if you were a shift worker or dealing with jet lag intermittently.

 

 

I don't know about him but melatonin seems vital.   

 

It drops drastically from puberty, it seems to do a ton of stuff, raise multiple endogenous antioxidants raise positive antiaging hormones, inhibit negative proaging hormones, increase telomeres, is a potent antioxidant, and some say it is the master conductor of the aging program, so powerful that in females can even reverse menopause if taken shortly after it(for how long unknown.).   Melatonin supplementation lengthens the lifespan of rodents by 30%.  And primates on CR do not experience the age related decline in melatonin production they keep youthful production for a longer period of time, and CR increases healthspan and lifespan in many species(suggesting perhaps part of the benefits are from maintaining youthful high melatonin at night.).

 

Remember mortality starts doubling every like 7-9 years, maybe the constant decline in melatonin production has no contribution to that, but it could be affecting it. (mortality lowest in humans when melatonin production is highest, could be coincidence) Also melatonin inhibits prostate tissue growth in some animals, a lot of men getting prostate growth and prostate issues, by later ages most men are having enlarged prostate issue, perhaps due to decades of lowered melatonin production.

 

Below graph of melatonin age related decline, it ain't pretty.   

Attached Thumbnails

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Edited by Castiel, 07 June 2021 - 03:57 PM.

[thompson92]

OK.  But he's a med student, not a 50 year old man.  Are we really optimizing hormone levels around a 15-18 year old?

[Castiel]

OK.  But he's a med student, not a 50 year old man.  Are we really optimizing hormone levels around a 15-18 year old?

 

Well the primate data suggests it'd likely stay that high if he had practiced CR from youth. 

 

Few people gonna practice CR, and the body will say lot of resources for the next generation of kids, lets ramp down melatonin and put the accelerator to the aging program to get rid of this person and make way for the next generation.    When resources are scarce the body will say the kids might not make it in this environment, better make sure to keep this person around lets ramp up repair and maintenance.

[Thingsvarious]

Well the primate data suggests it'd likely stay that high if he had practiced CR from youth. 

 

Few people gonna practice CR, and the body will say lot of resources for the next generation of kids, lets ramp down melatonin and put the accelerator to the aging program to get rid of this person and make way for the next generation.    When resources are scarce the body will say the kids might not make it in this environment, better make sure to keep this person around lets ramp up repair and maintenance.

I am using rapamycin for that -which is a perfectly apt CR-mimetic (without the downsides of caloric restriction -e.g. cortical atrophy, feeling cold, low energy levels).

[Thingsvarious]

 

 

1.  I don't understand why you regularly take melatonin.  How old are you that you think your own endogenous melatonin production is so diminished that you need to replace it with supplementation?  I can understand if you were a shift worker or dealing with jet lag intermittently.

 

2.  I don't understand your concept of 'non-endogenous' supplements.  Humans do not make Vitamin C.  Is that non-endogenous under your definition?  Sulforaphane is a highly researched hormetic phytochemical that probably has enormous benefits in upregulating endogenous antioxidant pathways.  It has been validated in the lab and there are supplements produced from reliable manufacturers that adhere to dosage and quality levels.  Personally, I'd rather take a broccoli-supplement assuming I had sufficient mineral and vitamin amounts through diet or a multivitamin.  I don't have time to write a dissertation on sulforaphane.  But why wouldn't this be a fairly good risk/reward approach or how is this lack of endogenous even relevant? 

 

See:  Xenohormesis by Howitz, et al.

 

Howitz, K., & Sinclair, D. (2008). Xenohormesis: Sensing the Chemical Cues of Other Species. Cell, 133(3), 387-391. doi: 10.1016/j.cell.2008.04.019

 

 

 

1. I do not take melatonin anymore.

 

2. Well, Sinclair is a goofball and idiot. I do not understand why that guy has come into the position he is now. Both sulphoraphane, resveratrol, and NAD-boosting hogus do nothing. While they cause some in-vitro change (if cells are drenched in these substances), they do absolutely nothing in vivo. If you truly want some benefits go for rapamycin, which is truly highly researched (and not just from a few affiliated "research" groups).

[Thingsvarious]

Another supplement I think highly of is glycine. Just 5g of glycine pre bed do increase my deep sleep numbers by quite a bit

[AlxM]

1. I do not take melatonin anymore.

 

2. Well, Sinclair is a goofball and idiot. I do not understand why that guy has come into the position he is now. Both sulphoraphane, resveratrol, and NAD-boosting hogus do nothing. While they cause some in-vitro change (if cells are drenched in these substances), they do absolutely nothing in vivo. If you truly want some benefits go for rapamycin, which is truly highly researched (and not just from a few affiliated "research" groups).

 

Did you stop taking melatonin because of your younger age?  

 

Great post by @Castiel regarding the chart on melatonin. I didn’t realize levels dropped so quickly.