2 replies to this topic

[Judd Crane]

I’ve been planning on trying out inosine but think it might interact with my sleeping medication. Zopiclone and inosine have similar structure (1) and affinities (2). Lower concentrations of inosine seems to be antagonistic of the benzodiazepine receptor since it binds to the chloride ionophore site, whereas higher concentrations seem to bind directly to the benzodiazepine receptor and illicit benzodiazepine-like effect (3).

 

Inosine has a 15 h half life. Could this be a dangerous interaction? I’m not worried about any temporary competitive inhibition on inosines part, but it would be nice to know if zopiclone can be used safely if I have insomnia when I try it. I'm planning on taking 0.5-1 grams of inosine.

 

Thankful for input. 

 

1 https://repository.a...e=1&isAllowed=y

2 https://www.scienced...304394082902695

3 https://books.google...raction&f=false

[Believer]

I did try it for its supposed NGF-releasing properties but I noticed no such effects.

I tried large and small dosages, intranasal and oral.

It's rapidly metabolized to uric acid and other things.

For me it increases physical stamina and mental stamina and then rapidly causes fatigue.

 

Edited by Believer, 21 January 2021 - 09:11 PM.

[zorba990]

Inosine was dubbed a "dud" in the 80s as a ergogenic. Mostly due to the gout it caused.