Obviously Lamictal (Lamotrigine) is known for it's anticonvulsant properties and treatment of bipolar disorders. This is because it inhibits the voltage-dependent sodium channels. This inhibits the release of glutamate and aspartate, the two dominant excitatory neurotransmitters in the central nervous system. I believe that glutamate is the prime cause of anxiety (besides low GABA sensitivity).
Why do I tell you this? Because for several decades we have been trying to find an ultimate and (hopefully) permanent cure for anxiety. Benzos haven't helped me, antidepressants haven't helped me, GABAergic supplements haven't helped me, NMDA antagonists haven't helped me, brain inflammation supplements haven't helped me... But Lamictal potentially can.
Unlike other anticonvulsants which act on the voltage-dependent calcium channels, Lamictal is unique. These anticonvulsants such as Gabapentin, Pregabalin, and even Phenibut are all prone to rapid tolerance and absolutely severe withdrawals. This is because they increase GABA. I hate to sound like ScienceGuy, but we need to socially distance away from anything that acts on GABA.
People have had luck with supplements that inhibit glutamate in some form or way, I haven't had such luck. Even Memantine failed to reduce the crippling anxiety that I suffer from.
So Lamictal might be the golden bullet everyone with "treatment-resistant" anxiety has been looking for. I plan to take my first dose later today.
I just thought I'd share this with you to see if anyone else had come to the same conclusion. Wish me luck.
References:
https://www.ncbi.nlm...books/NBK470442
https://pubmed.ncbi....nih.gov/9686247
https://www.ncbi.nlm...les/PMC2796047/
https://pubmed.ncbi....ih.gov/11830761