Not sure about extreme doses but in general yeah. idk about other effects of chloride itself but supplementing potassium as a good chunk of RDA looks to be fine.
the gastrointestinal side effects are way overblown it seems (20 / 26 studies reviewed did not show gastrointestinal distress from between 500mg - 3000mg potassium chloride, and of the 6 that did only 2 of them were in healthy individuals, and in 1 of those it matched the control group anyway)
The only consideration is if you have kidney problems / are on stuff that increases potassium absorption. if not it's good and can split the doses if still concerned. personally I would elevate the doses day to day to be on the safe side still.
A separate meta-analysis of 22 RCTs in individuals with normal kidney function that specifically searched for and recorded all available data on potential adverse effects concluded that there were no increased adverse effects, minor complaints, or major adverse events in the increased-potassium groups compared with the control groups in both adults and children.24 The intake of potassium in these trials ranged from less than 3500 to greater than 6000 mg (<90 to >155 mmol/d) and was from both diet and supplements
In (kidney disease) patients, safety concerns associated with potassium supplementation require medical supervision. Otherwise, in healthy adults who are the target of any UL value, there have been no reports of hyperkalemia.4 Clinical trials including potassium supplementation as high as 15600 mg (400 mmol/d) for several weeks and 4500 mg (115 mmol/d) for up to a year reported increased plasma concentrations but not beyond the reference range (3.5–5 mmol/L).69,70 Similar results were observed in a recent RCT comparing the bioavailability of potassium from potatoes and potassium supplement in healthy men and women. Supplementation with 2300 mg (60 mmol) of potassium gluconate added to a controlled diet containing 2300 mg (60 mmol/d) of potassium increased the plasma concentration from 3.6 to 4.1 mmol/L, but the increase was transient, lasting for approximately 4 hours, and followed immediately by increased renal potassium excretion.71 These findings suggest that the body is able to efficiently adapt to high potassium intake
https://www.ncbi.nlm...s/PMC6181280/
It doesn't have to be potassium chloride, if you don't want to raise your chloride levels. i just started taking potassium bicarbonate as bicarbonate may have some separate health benefits too.
there's a clinical trial that used 2.6g potassium bicarbonate with meals x3 daily, for 82 days. which is like 1 gram elemental potassium after each meal. didn't report adverse effects.
so I keep it to 900mg/1000mg elemental potassium at a time from 2.2g - 2.4g potassium bicarbonate (2x flat 1/4 tsp scoop) to be on the safe side, and I sip it slowly. I just leave about 30 / 40 mins after a meal to let it digest a bit, as idk how much the 1.4g alkaline bicarbonate could dilute stomach acid (??)
https://www.nejm.org...99406233302502 The potassium bicarbonate was given orally for 18 days in doses (60 to 120 mmol per day) that nearly completely neutralized the endogenous acid.
^ 60 - 120 mmol is about 6 - 12 grams potassium bicarbonate, which they said nearly completely neutralized their renal acid. wonder if <2.5 grams significantly hinders stomach acid though ?
there's about 500mg potassium in 250ml of orange juice
post above apparently our systems were designed around high intakes of potassium. but i'd like to know how they figured out that amount as >10,000mg. another one here says they were on 4x more potassium than our average intakes at like 2.5 grams https://pubmed.ncbi....h.gov/17275582/
Also I found higher potassium bicarbonate intake may prevent muscle wasting during periods of physical inactivity (through reducing nitrogen excretion or other mechanisms)
In a separate paper,6 researchers studying the effect of an oral potassium bicarbonate supplement (60–120 mmol/day for 18 days) in 14 healthy postmenopausal women found that the supplements reduced urinary nitrogen excretion [*good for gainz?] , an indicator of preserved lean body mass. The authors concluded that “[t]he magnitude of the KHCO3[potassium bicarbonate]-induced nitrogen sparing effect is potentially sufficient to both prevent continuing age-related loss of muscle mass and restore previously accrued deficits.” The amount of potassium bicarbonate supplement used in this study was 6 to 12 grams per day, which supplied 2.34 to 4.68 grams of potassium per day.
another one https://pubmed.ncbi....gov/29739680/ Alkalinization during long-term inactivity is associated with improved glutathione status, anti-inflammatory lipid pattern in cell membranes and reduction in protein catabolism at whole body level. This study suggests that, in clinical conditions characterized by inactivity, oxidative stress and inflammation, alkalinization could be a useful adjuvant therapeutic strategy.
examine: When it comes to potassium, benefits are seen when it comes to circulatory disorders such as cardiovascular disease and particularly stroke when potassium intake is increased.
This benefit is seen when potassium is consumed in minor increases (additional 500 mg a day) or large increases of a few grams over the course of the day, has similar protective effect regardless of the form of potassium consumed (food or supplemental), and shows benefit even if sodium is held constant.
Any beneficial effect of potassium on CVD is likely due to its antihypertensive effects. However, some research shows a benefit even when blood pressure is accounted for. For example, a 2016 meta-analysis of 16 cohort studies with a total of 639,440 participants found that those with the highest potassium intakes (median 103 mmol [4,027 mg] per day) had a 15% lower risk of stroke than those with the lowest potassium intakes (median 52.5 mmol [2,053 mg] per day). In addition, participants who consumed 90 mmol potassium/day (approximately 3,500 mg) had the lowest risk of stroke
In a review assessing studies using potassium supplements and whether or not they can induce hyperkalemia, it was found that doses of 50-75 mmol (1,950-2,925 mg) taken in divided doses over the course of the day increased serum potassium in a manner which did not appear dose dependent; no side-effects were reported in the review while biomarkers of renal function (urinary and serum sodium and creatinine) were unaffected.
Edited by CarlSagan, 28 July 2021 - 05:57 PM.
