AFAIK all the jabs produce this synthetic spike protein by design, and none contain copies of the actual viral Covid variant or anything close to it (like an inactivated version of it)Does this apply to mRNA (pfizer, moderna) ONLY?
Or does it ALSO apply to J&J?
So we can conclude the safest (yet not neccesarily safe) vaccine option at this point available in the US is the J&J? Since it lacks these lipid nanoparticles. Some of this gets very confusing
Without the actual Virus for your body to make immunity against, at least some of the puzzle is missing for it to be termed a vaccine.
Professional antigen-presenting cells would normally tear the virus up and present it to the next level of immunity - so that it takes a very big variant to not be recognized by T-cells, for instance.
In tis study they are proposing trying to emulate what your immune system does but what they are doing is a work in progress to try and simulate what the
body has been doing for a very long time. Also, I believe they are missing the part where pieces of the actual virus are presented. In any case you can see from
the table there that immune escape from jabs with spike proteins is very likely (Flexibility to match escape variants -> not easy) and isn't that convenient for needing 'top offs' continuously? $$$
from
T Cell Responses to Viral Infections – Opportunities for Peptide Vaccination
https://www.ncbi.nlm...les/PMC3997009/
"Once a virus infects a cell, the virus will use the protein-synthesis machinery of the host cell to synthesize its own proteins. During this process, some of the newly synthesized proteins will be degraded into peptide fragments and, if they have sufficient binding affinity, bind to MHC class I molecules. These MHC class I-peptide complexes will then be presented on the cell surface of an infected cell and activated CD8+ T cells, specific for the peptide, can recognize the MHC class I-peptide complex and induce apoptosis of the infected cell by releasing cytotoxic granules. Activation of these CD8+ T cells occurs in the draining lymph nodes, where antigen-presenting cells (APCs), such as dendritic cells (DCs), and naïve T cells encounter each other. In these lymph nodes, DCs and CD4+ T cells provide the co-stimulation necessary for proper activation of CD8+ T cells. This process is summarized in Figure Figure11 and will be further discussed in the next paragraphs."
Please jump in and correct any misunderstanding I have here, but broad immunity from any of the current jabs seems unlikely.
from https://www.nature.c...577-020-00436-4
"A recent report suggesting that antibodies to the virus may only be maintained for 2 months has caused speculation that ‘immunity’ to the virus may not be long lived3. Similarly, a rapid decline in antibodies was reported in mild cases4, although with a half-life of approximately 21 days for IgG we would expect this decrease. It is important to remember that memory B cells and T cells may be maintained even if there are not measurable levels of serum antibodies. Below, we outline our current understanding of B cell and T cell immunity to SARS-CoV-2 and potential immune correlates of protection that could inform vaccine efficacy studies (Fig. 1)."
"Studies of patients who became infected with SARS-CoV in 2003 suggested that the infection induced durable T cell responses lasting for 6 years but no long-term memory B cells9. Importantly, these T cells were shown to cross-react with the SARS-CoV-2 virus 17 years later10, but the extent to which they can provide protection is not known. Most importantly, the early global sharing of scientific data is vitally important to understand the complexities of the B cell and T cell responses in COVID-19 and to elucidate which immune responses provide protection from both the initial infection and reinfection."
I should state I am not sure I agree with the level of alarm presented below, but presenting it for completeness -- you decide for yourself.
Dr. M!chael Yead@n, Pf!zer former Vice President and Chief Scientist for Allergy & Respiratory who spent 32 years in the industry.
Full article : https://www.lifesite...d-to-your-death
Edited by zorba990, 17 June 2021 - 12:17 PM.
