3 replies to this topic

[Michael Lustgarten]

https://www.youtube....MWATxO9x4AaABAg

 

Papers referenced in the video:

Sirtuins, Healthspan, and Longevity in Mammals https://www.scienced....com/science...

 

Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH https://pubmed.ncbi....ih.gov/24011...

 

Resveratrol improves health and survival of mice on a high-calorie diet https://pubmed.ncbi....ih.gov/17086...

 

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice https://pubmed.ncbi....ih.gov/20974...

 

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer https://www.nature.c...ticles/ncomm...

 

Restoration of energy homeostasis by SIRT6 extends healthy lifespan https://pubmed.ncbi....ih.gov/34050...

 

The sirtuin SIRT6 regulates lifespan in male mice https://pubmed.ncbi....ih.gov/22367...

 

SIRT6 in Senescence and Aging-Related Cardiovascular Diseases https://pubmed.ncbi....ih.gov/33855...

 

Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling https://pubmed.ncbi....ih.gov/26940...

 

Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6 https://pubmed.ncbi....ih.gov/27101...

 

A Comprehensive Analysis into the Therapeutic Application of Natural Products as SIRT6 Modulators in Alzheimer’s Disease, Aging, Cancer, Inflammation, and Diabetes https://pubmed.ncbi....ih.gov/33920...

 

Acute Exercise Leads to Regulation of Telomere Associated Genes and MicroR A Expression in Immune Cells https://pubmed.ncbi....ih.gov/24752...

 

The effect of 12-week resistance exercise training on serum levels of cellular aging process parameters in elderly men https://pubmed.ncbi....ih.gov/32919...

[thompson92]

IIRC, some in the pro-reserveratrol camp would attribute the lack of life extension to the lack of NAD+ availability.  As such, SIRT1 may have been raised by reserveratrol but without NAD+ as a cofactor there was no resulting life extension.  I think this is why Elysium still went forward with a resveratrol-like activator in Pterostilbene, but added the NR for an NAD+ source.

 

I think Icariin and Oleic acid as SIRT6 activators warrant a closer look.  Vincent had a nice write-up on Icariin here:

 

http://www.anti-agin...um-and-icariin/

 

[Qowpel]

IIRC, some in the pro-reserveratrol camp would attribute the lack of life extension to the lack of NAD+ availability.  As such, SIRT1 may have been raised by reserveratrol but without NAD+ as a cofactor there was no resulting life extension.  I think this is why Elysium still went forward with a resveratrol-like activator in Pterostilbene, but added the NR for an NAD+ source.

 

I think Icariin and Oleic acid as SIRT6 activators warrant a closer look.  Vincent had a nice write-up on Icariin here:

 

http://www.anti-agin...um-and-icariin/

 

Good input thank you. I wonder if fasting activates Sirt6 at all. I sure hope it does.

[Phoebus]

 

https://www.nature.c...598-018-22388-5

 

 

The most potent SIRT6 activator, cyanidin, belonged to anthocyanidins, and produced a 55-fold increase in SIRT6 activity compared to the 3–10 fold increase for the others.

 

Elderberry contains the highest levels of cyanidin of any plant by far 

 

https://myintakepro....din-rich-foods/

 

Fucoidan quercetin and luteolin are all modulators of SIRT6, meaning they sometimes activate it and sometimes suppress it 

 

https://www.ncbi.nlm...les/PMC5484140/

 

 

 

 Using this technique, it was found that fucoidan activated SIRT6 deacetylation activity in a dose-dependent manner (Figure 7). Both methods demonstrate that fucoidan is an activator of SIRT6. Interestingly, it was demonstrated that higher concentrations of fucoidan (>16 µg/mL in the Western blot analysis method) resulted in the reduced activation of SIRT6 activity (data not shown). A similar observation was made in the HPLC-based assay at higher concentrations as well, indicating that fucoidan may have a dual role in SIRT6, similar to what was observed for quercetin and luteolin [13].