5 replies to this topic

[cjacek]

Hello,

My apologies if this was answered before but could someone please give an opinion as to what possible oral dose of Apigenin would be recommended for effective CD38 inhibition? I am working on a cocktail of sorts and would like to add Apigenin as one of the compounds, would also likely mix it into some fat containing meal before consuming. I am just asking about dosage.

Thank you,

Dan

Edited by cjacek, 07 June 2021 - 07:08 AM.

[Phoebus]

 this study showed that apigenin supplementation in mice prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity. The dose was 10 mg/kg and the human equivalent dose would be only about 50 mg or so if my math is correct (feel free to correct me if wrong)

 

https://journals.plo...al.pone.0195502

 

So if that dose is effective for calming inflammation, its a good bet it also suppressed CD38. 

Edited by Phoebus, 08 June 2021 - 02:08 AM.

[cjacek]

Interesting, thank you very much. It's strange that there isn't much human data available on this substance for more definitive dosing guidelines. 

Edited by cjacek, 08 June 2021 - 05:34 AM.

[drgs]

Keep in mind apigenin has 72 hour half-life, so if you're taking it every day, the dosage keeps building up

[orion22]

Keep in mind apigenin has 72 hour half-life, so if you're taking it every day, the dosage keeps building up

so what does that mean that it  suppresses cd 38 for 72 hours?

Edited by orion22, 04 September 2021 - 06:53 PM.

[rarefried]

I see research finding apigenin suppresses the vitamin d receptor, and, vitamin d responsiveness "in normal human keratinocytes".  

 

EG:

 

https://pubmed.ncbi....h.gov/10652242/

 

Above article mentions this suppression is counteracted by "the NFkappaB inhibitors sodium salicylate and caffeic acid phenethyl ester."   I assume, even with this counteracting effect, the suppression of vitamin d responsiveness remains a potential concern.

 

If so perhaps supplementing vitamin D on off-days (after clearance of Apigenin) a wise approach.