caloric restriction optimum nutrition increases SIRT 6. So does excercise. I would say hey, just do those things.
Quercetin also activates SIRT 6, and so does luteolin and cyaninidins (the dark pigment in berries)
Pure quercetin and a couple other derivatives activate sirt6 at high concentration, and inhibits it at low concentration. I checked the type of quercetin in onion and cocoa, and they seem to contain mainly derivatives that don't have this effect at low concentration.
A Review of Sirtuin Inhibitors in Therapeutics, Pharmaceutics, and Plant Research -Journal of Life Science | Korea Science
Quercetin is a plant flavonol in the flavonoid group. Natural quercetin can be found in onions, leeks, and broccoli [46]. Two quercetin derivatives, diquercetin and 2-chloro-1,4-naphthoquinone-quercetin, were identified as SIRT6 inhibitors [23](Fig. 4). The IC 50 value of diquercetin and 2-chloro-1, 4-naphtoquinone-quercetin is 130 μM and 55 μM, respectively [24]. The mode of inhibition of these inhibitors is different because diquercetin competes with nicotinamide adenine dinucleotide (NAD+), whereas 2-chloro-1,4-naphthoquinone-quercetin competes with the acetylated substrate in the catalytic site of SIRT6 [24].
Onions don't have much pure quercetin:
Quercetin in onion (Allium cepa L.) after heat-treatment simulating home preparation - ScienceDirect
Quercetin content in onion (Allium cepa L.), represented mainly by 3,4′-O-quercetin diglucoside (3,4′-Qdg) and 4′-O-quercetin glucoside (4′-Qmg), was examined in five cultivars before and after three cooking treatments (sautéing, baking, and boiling). Baking and sautéing produced a 7–25% gain in quercetin concentration, while boiling produced an 18% decrease in quercetin concentration. Ratios of 3,4′-Qdg to 4′-Qmg in tissues ranged from 1:1.3 and 1:1.7, and combined the two conjugates represented 89–90% of total flavonol content in treatment and raw control means indicating heat stability of the flavonols. Changes in flavonol concentrations as a result of cooking method were consistent across all five cultivars.
Cocoa also:
More Antioxidants in Cocoa | The Journal of Nutrition | Oxford Academic (oup.com)
Our group has identified and quantified three flavonols, isoquercitrin, quercetin 3-glucuronide and quercetin, in cocoa powder using HPLC-DAD coupled with HPLC-MS. The major flavonols in cocoa are isoquercitrin (23 mg/100 g), quercetin 3-glucuronide (5 mg/100 g) and quercetin (2 mg/100 g). In general, cocoa powder contains 30 mg flavonols/100 g.
Pure quercetin supplements might cause a inhibition effect who knows.
Luteolin also seems to activate sirt6 only at high concentration and inhibit it at low concentration:
The Identification of a SIRT6 Activator from Brown Algae Fucus distichus (nih.gov)
Phenolic compounds, such as quercetin and luteolin, also enhance SIRT6 deacetylation activity, albeit at very high concentrations
I don't know if celery seeds for instance would have derivatives of luteolins that are more likely to work at all concentration.
All this is not in vivo so it's hard to know for sure how it would turn out in vivo. Luteolin should increase NAD+ via CD38 inhibition, that might help.
Cyanidins don't seem to have that dual effect of concentration and also is more effective so perhaps it's the best way to try and do it. The richest source of cyanidins by far is black currant AFAIK, I've tried it but darn it it's hard to digest.
As for fucoidan, it seems to inhibit sirt6 at high concentration:
The Identification of a SIRT6 Activator from Brown Algae Fucus distichus (nih.gov)
Both methods demonstrate that fucoidan is an activator of SIRT6. Interestingly, it was demonstrated that higher concentrations of fucoidan (>16 µg/mL in the Western blot analysis method) resulted in the reduced activation of SIRT6 activity (data not shown). A similar observation was made in the HPLC-based assay at higher concentrations as well, indicating that fucoidan may have a dual role in SIRT6, similar to what was observed for quercetin and luteolin [13].
Edited by OlderThanThou2, 05 July 2021 - 07:06 AM.
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