15 replies to this topic

[RubiksKid]

Are there any telomerase-activating supplements/drugs apart from TA-65? And what about AGE breakers, specifically for glucosepane? I’ve kept up with my regimen, but it’s been a while since I’ve looked into new supplements.

[Castiel]

There's a big thread on telomerase activating compounds, thread name not intuitive but it covers a ton of compounds

Alternative methods to extend telomeres - Telomeres - LONGECITY

 

Also another interesting idea brought in that thread is to reduce mtor activity to reduce cell replication rate and allow even more effectiveness for telomerase activating compounds.

Edited by Castiel, 16 June 2021 - 05:41 PM.

[Believer]

Also another interesting idea brought in that thread is to reduce mtor activity to reduce cell replication rate and allow even more effectiveness for telomerase activating compounds.

Fasting is even better because it not only reduces cell replication and thus telomere attrition but it also removes the cells with the very shortest telomere lengths.

My father is doing this approach of fasting + epitalon.

[QuestforLife]

Telomerase activating molecules/compounds include:

TAM818 (strong but expensive)

Gotu Kola (asiaticoside/asiatic acid extract; looks like it could be a fairly strong activator)

Epitalon (likely strong, though evidence is mainly from Russia)

TA-65 (rather weak, also expensive, but lots of evidence)

A short cycle of a statin and sartan increase telomerase in vivo 

Various supplements like curcumin, milk thistle, Rhodolia, brocolli extract, Vit D, Omega-3s, astralagus, are all v.weak- weak telomerase activators, but you can buy combinations that are synergistic like from Enzymedica (for example)

 

Lots more information on my profile, particularly under 'Work on telomerase activators and other important telomere papers@

https://www.longecit...2-questforlife/

 

 

[RubiksKid]

Thank you all for taking the time to respond and share your knowledge with me. I'm following up with all of your suggestions.

 

There's a big thread on telomerase activating compounds, thread name not intuitive but it covers a ton of compounds

Alternative methods to extend telomeres - Telomeres - LONGECITY

 

Also another interesting idea brought in that thread is to reduce mtor activity to reduce cell replication rate and allow even more effectiveness for telomerase activating compounds.

 

That's an interesting idea. It makes sense.

 

 

Fasting is even better because it not only reduces cell replication and thus telomere attrition but it also removes the cells with the very shortest telomere lengths.

My father is doing this approach of fasting + epitalon.

 

I didn't know that. It seems like that would go hand in hand with CR.

 

 

Telomerase activating molecules/compounds include:

TAM818 (strong but expensive)

Gotu Kola (asiaticoside/asiatic acid extract; looks like it could be a fairly strong activator)

Epitalon (likely strong, though evidence is mainly from Russia)

TA-65 (rather weak, also expensive, but lots of evidence)

A short cycle of a statin and sartan increase telomerase in vivo 

Various supplements like curcumin, milk thistle, Rhodolia, brocolli extract, Vit D, Omega-3s, astralagus, are all v.weak- weak telomerase activators, but you can buy combinations that are synergistic like from Enzymedica (for example)

 

Lots more information on my profile, particularly under 'Work on telomerase activators and other important telomere papers@

https://www.longecit...2-questforlife/

 

Thank you! I'll absolutely be adding some of these to my regimen. 

[QuestforLife]

Fasting is even better because it not only reduces cell replication and thus telomere attrition but it also removes the cells with the very shortest telomere lengths.

My father is doing this approach of fasting + epitalon.

 

I can imagine a decent length fast would remove some old cells, in order to use their material to feed the body. I assume this is what you mean by removing cells with the shortest telomere lengths? Have their been any studies to this effect?

 

The reason I identified mTOR inhibition as being synergistic with telomerase comes from two places:

1. A study showed quite a convincing inverse correlation between the telomere length increase caused by epitalon and the increase in the proliferation rate of the lymphocytes exposed. Therefore slowing proliferation whilst increasing telomerase would lead to a bigger increase in telomere length. Also, there was another study showing how during a  short period (~2 weeks) mesenchymal stem cells were unable to divide because there was no more space in the culture, their telomeres actually got longer (see here )

2. I would be suspicious of 1 because of the inaccuracies of telomere length measurement except we have other evidence - with mouse cells senescing in 20% Oxygen but not in 3% Oxygen, which means their telomerase is at a sufficient level to prevent shortening (past a certain level) when growth conditions are reduced from a super oxygenated culture to a more physiological one(see here).

 

It all suggests we might be able to stop telomere shortening if we were to combine an telomerase activator or activators with mTOR inhibitor. To the extent that CR or fasting also reduces proliferation (via mTOR), it should also work. For me though an mTOR inhibitor is more reliable, as I don't know how long a fast would have to be to achieve the same effect. Reducing ROS might also combine well with a telomerase activator, but human cells' antioxidant capabilities are already pretty good, so it is unclear if, say, astaxanthin would make a big difference to telomere length. There is some evidence antioxidants do increase (relative) telomere length (see this thread). I also suspect that mTOR inhibition reduces ROS generation.

[Phoebus]

 

 

The isothiocyanate sulforaphane inhibits mTOR in an NRF2-independent manner

https://pubmed.ncbi....h.gov/31409554/

 

so  broccoli might help here, just be aware that if you cook it the enzyme that converts  glucosinolate into sulforaphane is destroyed. And if you cook it for a long time  much of the sulforaphane is destroyed. The best way to get sulforaphane is adding raw broccoli to a smoothie. 

[aribadabar]

so  broccoli might help here, just be aware that if you cook it the enzyme that converts  glucosinolate into sulforaphane is destroyed. And if you cook it for a long time  much of the sulforaphane is destroyed. 

 

Or you can sprinkle ground mustard seeds over cooked broccoli to re-add myrosinase.

[Phoebus]

Or you can sprinkle ground mustard seeds over cooked broccoli to re-add myrosinase.

 

Sure but you better chew chew chew 

 

The only time the myro does anything is in your mouth. 

 

See here for complete explanation 

 

https://www.reddit.c...large_doses_of/

 

I am telling you, adding raw broccoli to your smoothie is the easiest, most efficient method of ingesting sulforaphane 

[Mind]

Fasting is even better because it not only reduces cell replication and thus telomere attrition but it also removes the cells with the very shortest telomere lengths.

My father is doing this approach of fasting + epitalon.

 

Is the combination working? Are you doing any testing to get objective data.

[Believer]

Is the combination working? Are you doing any testing to get objective data.

So far there is nothing to report visually as far as I can see although he says that the day after fasting when he refeeds he feels more mental clarity and his muscle function is better than it was before fasting. I have photos of him from a year back and every year or so I take new photos and compare them.

Unfortunately we don't have the money or the ability to get proper testing.

 

[QuestforLife]

So far there is nothing to report visually as far as I can see although he says that the day after fasting when he refeeds he feels more mental clarity and his muscle function is better than it was before fasting. I have photos of him from a year back and every year or so I take new photos and compare them.

Unfortunately we don't have the money or the ability to get proper testing.

 

Recovery from exercise should be noticeably better; I noticed that with both TAM818 and (injecting) epitalon.

 

If your father exercises he can keep a record of this.

 

He needs to be careful with fasting at advanced age; it is possible to do more harm than good. 

 

Oh, and as telomere tests are hard to find now/expensive/unreliable, the neutrophil: leukocyte ratio (NLR) will give you a rough idea if you are going in the right direction with telomere length in the immune system (see post #549), a white blood cell test is inexpensive and you are aiming for a low score. 

Edited by QuestforLife, 25 June 2021 - 07:37 AM.

[Mind]

 

 

He needs to be careful with fasting at advanced age; it is possible to do more harm than good.

 

Could you expound a little more about this point? Any studies on this?

[QuestforLife]

Could you expound a little more about this point? Any studies on this?

Intermittent fasting can occasionally induce arrythmia, see: https://www.thecardi...in-case-report/

I was a follower of Wulf Droge, who was an early advocate of intermittent fasting and cysteine supplementation (as whey).

See: https://www.ncbi.nlm...les/PMC1569588/

He died unexpectedly of a heart attack.

Admittedly the evidence isn't overwhelming but nevertheless to me it's obvious that if you are carrying extra fat around the waist fasting will probably benefit you, whereas someone who is suffering from loss of body mass is probably going to harm themselves. For some reason everyone thinks going catabolic is anti-aging.

[manofsan]

Telomerase activating molecules/compounds include:

TAM818 (strong but expensive)

Gotu Kola (asiaticoside/asiatic acid extract; looks like it could be a fairly strong activator)

Epitalon (likely strong, though evidence is mainly from Russia)

TA-65 (rather weak, also expensive, but lots of evidence)

A short cycle of a statin and sartan increase telomerase in vivo 

Various supplements like curcumin, milk thistle, Rhodolia, brocolli extract, Vit D, Omega-3s, astralagus, are all v.weak- weak telomerase activators, but you can buy combinations that are synergistic like from Enzymedica (for example)

 

Lots more information on my profile, particularly under 'Work on telomerase activators and other important telomere papers@

https://www.longecit...2-questforlife/

 

 

So is there any particular type of physical activity that can also activate telomerase production? I was just wondering if I could, for example, perform that relevant physical activity in coordination with taking the oral substance. Like, for instance, I'd then take the Gotu Kola (or whatever) and then perform the particular physical activity.

 

I'm saying that because I've had better luck using the Fisetin in connection with doing vigorous cardiovascular exercise.

So that leads me to believe that activity+supplement is better than just supplement alone.

 

Is there any known exercise or activity that can activate telomerase production?

Anybody have any idea?

[QuestforLife]

So is there any particular type of physical activity that can also activate telomerase production? I was just wondering if I could, for example, perform that relevant physical activity in coordination with taking the oral substance. Like, for instance, I'd then take the Gotu Kola (or whatever) and then perform the particular physical activity.

 

I'm saying that because I've had better luck using the Fisetin in connection with doing vigorous cardiovascular exercise.

So that leads me to believe that activity+supplement is better than just supplement alone.

 

Is there any known exercise or activity that can activate telomerase production?

Anybody have any idea?

 

Lots of lifestyle interventions supposedly increase telomere length, for example:

1. aerobic exercise seems to have some evidence of a small benefit

https://www.scienced...30773X?via=ihub

2. meditation; this meta analysis shows a small benefit

https://systematicre...643-021-01699-1

3. diet: this meta analysis shows no clear benefit 

https://www.karger.c...FullText/486586

 

I am highly suspicious of these kinds of studies; I suspect lifestyle interventions may either reduce the rate of telomere shortening through reduced inflammation (the three above interventions could conceivably do this), for example, or perhaps increase the rate of turnover of cells from the underlying stem cell compartment (one could imagine aerobic exercise might do this). Either of these mechanisms may have its own benefit, but need to be separated out from increasing telomerase. For example, the aerobic exercise study above (1.) had a small but measurable benefit to telomere length over the study duration, but no effect on telomerase. 

 

Drinking coffee (here) and potentially eating dark chocolate (here) may increase telomerase, so could be paired with a telomerase activator.