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Senescence-associated-β-galactosidase (SA-β-gal), NAD my issues

senescence-associated-β-galactosidase sa-β-gal fisetin quercetin jinfiniti dasatinib foxo4-dri

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#31 BrentS

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Posted 04 September 2023 - 02:52 AM

Well, it has taken more than a year, but I am ALMOST ready to start hyperbaric oxygen with my own personal chamber.  It is installed in my house and SHOULD be operational in the next month.  I am now updating what I did since the last cycle.

4 March 2022 3g Quercetin 3g Fisetin  

5 March 2022 3g Quercetin 3g Fisetin    

6 March 2022 3g Quercetin 3g Fisetin    

7 March 2022 3g Quercetin 3g Fisetin    

8 March 2022 3g Quercetin 3g Fisetin    

After this cycle I decided to switch from 5 days per 6 weeks to 2 days every ~2ish weeks.

Mostly because by the 5th day I was pretty sick of the taste of Fisetin.

 

16 Mar 2022 1 Hour at 2atm HBOT  

23 Mar 2022 1.5 Hours at 2atm HBOT  

30 Mar 2022 1.5 Hours at 2atm HBOT    

   

29 Apr 2022 3g Quercetin 3g Fisetin

30 Apr 2022 3g Quercetin 3g Fisetin    

 

12 May 2022 1.5 Hours at 2atm HBOT  

     

13 May 2022 3g Quercetin 3g Fisetin

14 May2022 3g Quercetin 3g Fisetin    

 

14 May 2022 1.5 Hours at 2atm HBOT  

17 May 2022 1.5 Hours at 2atm HBOT  

18 May 2022 1.5 Hours at 2atm HBOT  

19 May 2022 1.5 Hours at 2atm HBOT  

20 May 2022 1.5 Hours at 2atm HBOT  

21 May 2022 1.5 Hours at 2atm HBOT  

25 May 2022 1.5 Hours at 2atm HBOT  

26 May 2022 1.5 Hours at 2atm HBOT  

     

3 Jun 2022 3g Quercetin 3g Fisetin

4 Jun 2022 3g Quercetin 3g Fisetin

     

17 Jun 2022 3g Quercetin 3g Fisetin

18 Jun 2022 3g Quercetin 3g Fisetin  

   

1 Jul 2022 3g Quercetin 3g Fisetin

2Jul 2022 3g Quercetin 3g Fisetin  

   

22 Jul 2022 3g Quercetin 3g Fisetin

23 Jul 2022 3g Quercetin 3g Fisetin  

   

5 Aug 2022 3g Quercetin 3g Fisetin

6 Aug 2022 3g Quercetin 3g Fisetin

 

19 Aug 2022 3g Quercetin 3g Fisetin

20 Aug 2022 3g Quercetin 2.8g Fisetin

Changed from Swanson to DoNotAge brand Fisetin during above cycle      

 

9 Sep 2022 3g Quercetin 2.8g Fisetin

10 Sep 2022 3g Quercetin 3.2 g Fisetin      

 

23 Sep 2022 3g Quercetin 2.8g Fisetin

24 Sep 2022 3g Quercetin 3.2 g Fisetin      

 

7 Oct 2022 3g Quercetin 2.8g Fisetin

8 Oct 2022 3g Quercetin 3.2 g Fisetin      

 

28 Oct 2022 3g Quercetin 2.8g Fisetin

29 Oct 2022 3g Quercetin 3.2 g Fisetin      

 

11 Nov 2022 3g Quercetin 2.8g Fisetin

12 Nov 2022 3g Quercetin 3.2 g Fisetin      

 

25 Nov 2022 3g Quercetin 2.8g Fisetin

26 Nov 2022 3g Quercetin 3.2 g Fisetin      

 

16 Dec 2022 3g Quercetin 2.8g Fisetin

17 Dec 2022 3g Quercetin 3.2 g Fisetin      

 

30 Dec 2022 3g Quercetin 2.8g Fisetin

31 Dec 2022 3g Quercetin 3.2 g Fisetin      

 

13 Jan 2023 3g Quercetin 2.8g Fisetin

14 Jan 2023 3g Quercetin 3.2 g Fisetin      

 

3 Feb 2023 3g Quercetin 2.8g Fisetin

4 Feb 2023 3g Quercetin 3.2 g Fisetin      

 

17 Feb 2023 3g Quercetin 2.8g Fisetin

18 Feb 2023 3g Quercetin 3.2 g Fisetin      

 

3 Mar 2023 3g Quercetin 2.8g Fisetin

4 Mar 2023 3g Quercetin 3.2 g Fisetin      

 

24 Mar 2023 3g Quercetin 2.8g Fisetin

25 Mar 2023 3g Quercetin 3.2 g Fisetin      

 

7 Apr 2023 3g Quercetin 2.8g Fisetin

8 Apr 2023 3g Quercetin 3.2 g Fisetin      

 

21 Apr 2023 3g Quercetin 2.8g Fisetin

22 Apr 2023 3g Quercetin 3.2 g Fisetin      

 

5 May 2023 3g Quercetin 2.8g Fisetin

6 May 2023 3g Quercetin 3.2 g Fisetin      

 

30 May 2023 3g Quercetin 2.8g Fisetin

31 May 2023 3g Quercetin 3.2 g Fisetin      

 

9 Jun 2023 3g Quercetin 2.8g Fisetin

10 Jun 2023 3g Quercetin 3.2 g Fisetin      

 

23 Jun 2023 3g Quercetin 2.8g Fisetin

24 Jun 2023 3g Quercetin 3.2 g Fisetin      

 

14 Jul 2023 3g Quercetin 2.8g Fisetin

15 Jul 2023 3g Quercetin 3.2 g Fisetin      

 

28 Jul 2023 3g Quercetin 2.8g Fisetin

29 Jul 2023 3g Quercetin 3.2 g Fisetin      

 

11 Aug 2023 3g Quercetin 2.8g Fisetin

12 Aug 2023 3g Quercetin 3.2 g Fisetin      

 

25 Aug 2023 3g Quercetin 2.8g Fisetin

26 Aug 2023 3g Quercetin 3.2 g Fisetin      

 

1 Sep 2023 3g Quercetin 2.8g Fisetin

2 Sep 2023 3g Quercetin 3.2 g Fisetin

 

During above year I did a dozen sessions of Hyperbaric Oxygen at a private clinic, but the cost was a lot, so I decided to buy my own chamber instead of paying tens of thousands for more sessions.

I also switched from Swanson Fisetin to DoNotAge Fisetin, as I was annoyed at pulling the 100mg capsules apart and I despised the taste.  DoNotAge has 400mg capsules, and I only had to take 7 or 8 a day.

 

Edit:  tried to paste tables, didn't work, manually edited


Edited by BrentS, 04 September 2023 - 03:03 AM.


#32 BrentS

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Posted 04 September 2023 - 03:18 AM

Below is the test result for senescence for the last year and a half of treatment approximately every second weekend of 3g each Quercetin and Fisetin, with a few HBOT sessions a year ago. 

I did not do another telomere length test this year as I felt that a dozen HBOT sessions would be unlikely to be enough to give statistically significant results.

 

It appears that taking 6g (3g each per day) of the senolytics every second week was pretty much good enough to keep the levels low, but not enough to continue the decrease.

Attached Files


Edited by BrentS, 04 September 2023 - 03:20 AM.

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Also tagged with one or more of these keywords: senescence-associated-β-galactosidase, sa-β-gal, fisetin, quercetin, jinfiniti, dasatinib, foxo4-dri

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