Hello,
I have no idea what psychiatrists and researchers are talking about with their prejudice against 5-HT2A receptors. It seems they can attach anything with a negative label and never need to explain themselves clearly or make sense. And they like to stay unclear about what they want to achieve with antagonism, just a nullification or a long-term upregulation. Even if it's the opposite, it is rarely deemed worth a remark (or an investigation on their own part).
I think if you try anything with a 5-HT2A antagonism, you will probably feel absolutely miserable while it's effective, with a strong feeling of relief and possibly improvement when it has worn off.
White Willow bark (Salix Alba) extract and Feverfew are two examples of strong natural 5-HT2A antagonists. Though Salix Alba also has 5-HT1D agonism, which dampens its effect a litte (not totally), and a much shorter half-life. After 3 or 4 hours one will probably feel fine, but a little down inbetween.
Feverfew is both an antagonist of 5-HT2A and 5-HT2B, and the latter seems to be its intended main effect. Nonethelss both of these natural agents feel fairly similar. Though Feverfew takes about 9 hours to wear off. It also has some other biochemical effects which may give one an "interesting" feeling (or aroused) before the end of 2 hours, but after that to the end of 9 hours it's misery. (At the end of it you might feel aroused again, just to take up that sidenote. Also overall relieved.)
I've tried Mirtazapine too, it's crap, simply crap.
The antagonism has nothing positive about it, nothing whatsoever, it hampers normal psychological functioning and makes one feel cranky, maybe even with pains and headache, and in dire need of some dopamine or happiness/equilibrium. It is a fundamental mechanism with a definite bias towards being positive rather than negative.
Edited by DaveX, 31 October 2021 - 05:13 AM.
