I am happy to share. Just thought I’d be brief in the initial posting.
Let me say at the outset regarding the various putative ageing biomarkers, that I have come to regard these, at best, as secondary to the seemingly simplistic ones already known for decades – resting heart rate, BP, etc – which will anyway be the reference of the gene-based ones. Why? Because if, say, a gene-based one showed a person was getting younger but was frailer, rising resting heart rate, couldn’t walk far, etc, then I’d go with the latter as being a better assessment of longevity than a gene-based one predicting longer life. Having said that, I base my life and research on direct factors – my BP, resting heart rate, hand-grip, creatine levels, CRP, etc.
An additional caution of the gene-based ageing measures is that these are necessarily based on averages, and any individual may/will vary from this. So a person needs to know their own ageing – probably dubiously based on this average. Whereas said individual can tell if they are walking more slowly, cannot get up off the chair quickly, etc.
I looked at your link to the loss of resilience as a putative predictor. Too complex for an individual to easily access.
However, to my own approach>
I measure over a hundred biomarkers, many via serum and urine analysis – as you correctly thought, not daily but about monthly. I have taken these up to about 100 times over the last 13 years, giving me fairly robust correlations.
I have reduced them to about 30, in three groups, for lifestyle action – for cardio-vascular, kidney, and cancer. I have a further 3 for body composition, done daily – muscle-mass, bone-mass and body-fat (trunk and visceral fat correlates highly with the overall body-fat, so I no longer analysis this separately). And a host of others: sleep, temperature, oximeter, morning HRV. I use an iterative approach – check the correlations with my present lifestyle; change what I do in the light of these, and test again in about a month.
My CV ones are: BP, resting heart rate, morning PNN50 when exercising, CRP, LDL, Total Cholesteral:HDL, Apolipoprotein-B, Migraines, Total Cholesterol, and HbA1ac.
My kidney ones are: creatinine, urea, cystatin, potassium, albumin, bilirubin, albumin:globulim.
My cancer ones are: Cxbladder, NMP22, CA19-9, CEA, CRP, AST:ALT, Neutrophil:Lymphocytes, Hb:PLT, Basophils, Eosinophils, CRP: Albumin
I look to see whether I’ve improved on all of these over time, and have a combined score for each health/illness group (based on normalising each variable).
Please see attachment for graphs and tables.