Based on the data available from the human D&Q senolytics trial, the reduction in senescent cells was as follows from a single cycle:
p21 cells = 35%
p16 cells = 17%
Sgal cells = 62%
Mathematically, it requires 3-4 passes to reduce the Pool of all 3 cell types to below 50%.
Some sources state that it takes 6-8 weeks for cells to become senescent. Data also shows that SASP will convert normal cells to a senescent state.
I propose to have significant effect, at least 3 cycles of senolytic treatment must be performed every 8 weeks to be effective.
Or the effectiveness of one cycle of senolytics must be significantly enhanced.
Edited by sensei, 07 February 2022 - 03:52 PM.