2 replies to this topic

[reason]

When various talking heads unite to tell us that the longevity industry isn't actually working to extend human life span, and it is all about letting you die at the usual time with less arthritis and pain, I'm not entirely sure who they think needs to be reassured in this way. The character of the powers that be, in the English language world anyway, appears to be that they are terrified of all possible change, and project that fear onto the populace. Their propaganda follows that apparent view. Under the hood, from person to person, who knows why they think it is necessary to toe the current party line that work on the mechanisms of aging will not lengthen life spans. It continues to puzzle me.

Altos Labs has signed up a dream team of scientists, numerous Nobel laureates among them. They will start work in the spring at two labs in the US and one in the UK, with substantial input from researchers in Japan. Their aim is to rejuvenate human cells, not with an eye on immortality - as some reports have claimed - but to stave off the diseases of old age that inexorably drive us to the grave. "This is not about developing the first 1,000-year-old human; it's about ensuring old age is enjoyed and not endured. Who wants to extend lifespan if all that means is another 30 years of ill health? This is about increasing healthspan, not lifespan."

Phrases such as "solving ageing" and "solving death" are seen as wrong-headed. "Apart from being silly at the moment, it raises all kinds of societal issues. I think it's morally dubious. Huge things would percolate through society with a substantial increase in life expectancy brought about by human intervention. We're living longer and longer already. People are suffering from disability and loss of quality of life because of ageing. That's what we should be trying to fix. We should be trying to keep people healthier for longer before they drop off the perch. Stay healthy then drop dead, die in your sleep. I think that's what most people want."

Link: https://www.theguard...-ageing-process

View the full article at FightAging

[Kentavr]

If the longevity industry was working on the problem of aging, then it would be working on the extracellular matrix and microRNAs that code for aging proteins. It would also solve the problem of how to remove these aging proteins.

 

In fact, only a few laboratories are involved in aging. These are Irina Konboy, who recently gave a good talk on the proteins of aging, and Dmitry Veremeenko from Russia, who is working on the extracellular matrix.

 

No intervention on a LONG-LIVING animal has extended MAXIMUM lifespan more than diet. Why?

 

1. When you have a lot of proteins in your body that prevent stem cells from regenerating organs and tissues, you will die, no matter how well you remove aging cells. Even if you take HMN and SkQ1 every day. MicroRNA that are sent by the hypothalamus and pituitary to synthesize proteins that initiate aging will not leave you a chance. They will also age your cells and you will be drinking senolytics for the rest of your life. Until the moment of his death.

 

But there will be no use, since senolytics destroy aging cells but not proteins.

 

All LONG-LIVING (!) mice that took NMN and senolytics died despite being in good physical shape, with smooth coats, no hump, etc. But they became corpses. Yes, it improved their fitness, but they didn't live longer than mice that were on a diet.

 

2. No matter how good you are at removing senescent cells, if the extracellular matrix squeezes you, you too will die. Only with healthy cells. Yes, your average life expectancy will increase, but not your maximum life expectancy. 120 years cannot be overcome in this way. And the hard matrix also makes your cells old, and it can also initiate cancer. 

 

Because it sends signals to cells to become senescent, and also, by squeezing them, activates cancer genes.

 

He will simply CRUSH you at 90, and you will not live to 100. With good cells and senolytics.

 

The longevity industry largely fails to see the true causes of body aging. May God bless everyone who reads this information.

Edited by Kentavr, 24 February 2022 - 04:43 PM.

[Mind]

There are definitely some discussions to be had about what the true cause of aging is...but the main point is the "marketing".

 

New well-funded efforts in the longevity field are going out of their way to say "we are not trying to help people live longer...don't freak out....that would be horrible, of course". (paraphrasing)

 

I don't see hardly any problems with people living healthy and longer, except for the "immortal dictator" problem. With more and more power and control being concentrated within a small number of elite billionaire psychopaths, it could be a miserable future for the average human.