Please check your FERRITIN and Iron Transferrin Saturation (TSAT) levels. These are dirt cheap labs, and your doc shouldn't balk at ordering them. You can even get them yourself without a doctor through online labs.
https://www.lifeexte...0051/iron-panel
https://www.lifeexte...itin-blood-test
Iron elevation has been associated with gout, as well as other substantial health issues (cancer & heart disease). Your early onset gout may well be a lifesaving flag to a medical issue (hemochromatosis) many doctors miss as Iron labs are no longer routinely done in most blood testing.
https://academic.oup...12/1550/1784793
Near-iron deficiency-induced remission of gouty arthritis
Previous evidence supports a role for iron in the pathogenesis of gout. For example, iron, when added to media containing urate crystals, stimulated oxidative stress with subsequent complement and neutrophil activation. Conversely, iron removal inhibited these responses as well as urate-crystal-induced foot pad inflammation in rats in-vivo. The objective of the present study was to investigate whether or not iron removal may improve the outcome of gouty arthritis in humans as well.
Methods. Quantitative phlebotomy was used to remove iron in 12 hyperuricaemic patients with gouty arthritis and maintain their body iron at near-iron deficiency (NID) level (i.e. the lowest body iron store compatible with normal erythropoiesis and therefore absence of anaemia).
Results. During maintenance of NID for 28 months, gouty attacks markedly diminished in every patient, from a cumulative amount of 48 and 53 attacks per year before (year –2, –1), to 32, 11 and 7 during induction (year 0) and maintenance (year +1, +2) of NID, respectively. During NID, attacks were also more often of milder severity.
Conclusions. During a 28-month follow-up, maintenance of NID was found to be safe and beneficial in all patients, with effects ranging from a complete remission to a marked reduction of incidence and severity of gouty attacks.
https://arthritis-re...3075-018-1668-y
The relationship between ferritin and urate levels and risk of gout
"Increased ferritin levels associated with gout and flare frequency. There was evidence of a causal effect of iron and ferritin on urate."
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Warning! The "Normal Range" for ferritin is set quite high by most labs (300+ for males), however, "OPTIMAL" levels for ferritin are actually far lower (50 to 100). Do not let your doctor tell you ferritin of 150, 200, 250 is fine and normal. If your ferritin is this high at 30 years of age, you are absorbing way too much dietary iron and may have genetic hemochromatosis.
Ferritin can sometimes have a false positive elevation when infection or extreme inflammation is present. This is why you add transferrin saturation (TSAT) to confirm the iron elevation. Again, with TSAT, you don't want to be in the upper third of the "normal" range. You want to be in the middle third (20-30).
Excess iron is very easy to bleed off, but unfortunately blood donation of therapeutic phlebotomy is the only practical solution. Donate only "Whole Blood" as the iron is in the red cells. Plasma and Platelet donation does not remove any iron. Donate blood in the afternoon, at least an hour after lunch, and only when well hydrated; (not in the morning when you're hypoglycemic and dehydrated).
Research "Ferrotoxic Disease" for more on the dangers of iron elevation, & I hope this (iron reduction) might be an easy fix for you.
https://www.longecit...isease-omnibus/
Best Wishes for Better Health.
Edited by Dorian Grey, 01 May 2022 - 04:41 AM.