14 replies to this topic

[Qowpel]

So there is the theory of programmed aging.   I recently have read a paper in which thousands of individuals had particular levels of particular blood proteins tested, and the main finding was, that these protein numbers changed drastically at roughly age 34, followed by consistency again, then changed again at roughly 60 years old, consistency again, then once more at roughly 78 years old. Each time these protein levels changed there were specific aging-like changes to many bodily/systems and tissues, such as the ECM for example. 

 

This has me wondering if any of us here have noticed something similar in ourselves, and I think it is very important for us all to discuss of course. 

 

Did anyone here at roughly the above mentioned ages, notice sudden shifts in their external looks (skin quality suddenly getting worse, sagging in skin/fat/other facial features, hair loss, hair greying? Did anyone notice sudden aging around perhaps not only looks but also regarding their bodily health as well? I am very interested in hearing from you guys and think we should actually perhaps start a poll on this. If we could all contribute here perhaps we could uncover a great clue as to this theory of programmed aging, and try to figure out ways to delay it/lessen the severity.

 

For those of us that did NOT notice such aging shifts at the above-mentioned hallmark ages, did you notice aging spikes at any other ages? Regardless if you did or did not what are your anti aging strategies?

Edited by Qowpel, 24 July 2022 - 02:17 AM.

[Qowpel]

Here is a link to the paper https://sci-hub.st/d...-019-0673-2.pdf

[johnhemming]

I am not sure that link works.  I thnnk the domain name is wrong in some way.  The paper is an interesting paper.

 

I haven't noticed any particular phases myself and this page talks about how I am handling my protocol

https://johnhemming....cent-cells.html

 

 

[Danail Bulgaria]

It is consistent with a hormonal theory of aging, that I red some (long) time ago. It postulated, that each period of our life, is controlled by different levels of hormones. From zygote to a child, from child to puberty, from puberty to adult, and from adult to several periods until aged person. That was the reason many people to take human growth hormoe (HGH) to stop thier aging. We may eventually suggest, that different levels of the hormones would result in different levels of certain proteins in the blood. I wonder what happened with the HGH taking people.

[Qowpel]

It is consistent with a hormonal theory of aging, that I red some (long) time ago. It postulated, that each period of our life, is controlled by different levels of hormones. From zygote to a child, from child to puberty, from puberty to adult, and from adult to several periods until aged person. That was the reason many people to take human growth hormoe (HGH) to stop thier aging. We may eventually suggest, that different levels of the hormones would result in different levels of certain proteins in the blood. I wonder what happened with the HGH taking people.

I do wonder if this is the case here, if hormones are the reaasn for this specific protein blood level change. I have to wonder thouhg, what hormone or hormones would it be? Ses hormones, HGH, something else? Very difficult to tell. Plus it would have to be a sudden hormone change known to happen in individuals at around those hallmark ages. For example, in men, if we are talking sex hormones, the androgens specifically, there are only gradual yearly losses after puberty for quite a while so it isnt like testosteronem or dht is just plummeting dramatically at 34. Or, idk. Maybe this is a stupid take on my part. I am just thinking out loud.

[Danail Bulgaria]

It is not that hard to be correlated hormnal chnges with protein fraction levels.

The above experment can be repeated with a hormonal exams and a status taken from an endocrynologist.

 

Proving the correlation is not a coincidence is hard though,

Protein elctroforesis should be able to give a perspective what exact fractions of proteins are there in the blood in young and old. If a correlation is made with a speciphic protein fraction in a particular age, the proteins in these fractions can be sequenced and determined what exactly these proteins are. Then it may be suggested would and how the proteins correlate with the speciphic hormone. The suggestion guessed have to be tested and proved or disproved.

It is not as being impossible the work to be continued.

 

[mbdrinker]

I agree that aging is more in steps than gradual. By 40 suddenly many illnessess start to manifest and from 34 ageing speed increases and especially after 40. 40 is start of old age... mortido becomes dominating over libido and many people lose aim to live further... a lot of info on this site is bullshit imho for example all concerning immortality. What you only can do is taking care of your health to look better at a given ageing step but you cant extend your life. Some people die young and healthy and others old and ill.. 

[Mind]

I agree that aging is more in steps than gradual. By 40 suddenly many illnessess start to manifest and from 34 ageing speed increases and especially after 40. 40 is start of old age... mortido becomes dominating over libido and many people lose aim to live further... a lot of info on this site is bullshit imho for example all concerning immortality. What you only can do is taking care of your health to look better at a given ageing step but you cant extend your life. Some people die young and healthy and others old and ill.. 

 

As with everything, the data is probably a bell curve around those transition points, not everyone will have the same changes at the same years. My hair did not start getting a little grey until my upper 40s. I felt vigorous into my late 30s (still felt I had similar vigor as in my mid to late 20s).

 

It is true there are no proven rejuvenation therapies available right now, but many are in the pipeline, more than ever before. We will find out within a couple of years whether or not our current theories about aging is correct.

[mbdrinker]

All your theories will fail. It's impossible to fool the nature and silly. The earth is just a planet in unknown universe. Jew einstein was a lier. I only hope that their moshiah will be dethroned soon and at least people will live happily their short lives.

Legalizing ephtonasia would be a great step in helping people

[Rocket]

As with everything, the data is probably a bell curve around those transition points, not everyone will have the same changes at the same years. My hair did not start getting a little grey until my upper 40s. I felt vigorous into my late 30s (still felt I had similar vigor as in my mid to late 20s).

It is true there are no proven rejuvenation therapies available right now, but many are in the pipeline, more than ever before. We will find out within a couple of years whether or not our current theories about aging is correct.

I'm still getting pimples but not many. My hair and beard have small touches of gray. Others may age are really gray. I have the vitality and mental attributes of people much younger. I'm taken aback when someone 22 thinks i should be wearing sweater vests and lying down on the couch after work of they're surprised that I take may kid to an amusement park and ride the rides or that i train with weights and do physics in my spare time.

Someone 27 told me today that by my age its useless do eatb healthy and exercise because it won't add any time to life and i should just eat and drink whatever because at my age there's no point trying to be healthy..... And he really meant it. Other people my age think i look years younger and I'm in great health because i have muscles.

Idk but different people age differently and i feel i got lucky. But it doesn't happen in phases. Its gradual and uniform

Edited by Rocket, 18 November 2022 - 02:28 AM.

[mbdrinker]

Big muscles does not mean you have good skin or health inside. Sometimes diseases manifest abruptly even with energetic people boasting of good genetics... it's like some people live unhealthy but long and others abruptly die young. No evidence for bodybuioders and athlets to be healthier.... Just get rid of your weight to become very thin and then you may judge how actually you are young....

[mbdrinker]

This is kind of a test, my patented knowhow that you should lose weight to match your 20 year old weight to objectively compare degradation process. If you had same bodybuilder's weight at 20 you should get your teen weight you had had before bodybuilding... don't deceive yourself

Edited by mbdrinker, 18 November 2022 - 08:31 PM.

[mbdrinker]

The thing is that excessive muscle mass may make your body think that you are young and support younger metabolism but with teen weight this won't work.... and your actual age will manifest probably with loss of libido. I know slender 80 year old guys who fucked at that age without your tricky deceptive tricks

[Avatar of Horus]

The study's title is:
Undulating changes in human plasma proteome profiles across the lifespan - 2019 Dec
https://pubmed.ncbi....h.gov/31806903/

 

Two figures from the study:
Figure 3 c
c) Number of plasma proteins differentially expressed during aging. Three local peaks at the ages of 34, 60 and 78

 
Figure 2 a

 
These changing protein profiles seem to correlate well with the overall aging-related deterioration, especially its speed-up after the age of 60 years.

[mbdrinker]

Death is an inherent constituent of living beings. So all attempts aimed at immortality are doomed to fail and are against nature and its priciples. I would better give people the right to pass to a better world painlessly instead of lengthening boring life without future where only the children of the rich thieves have all rights and chances for pleasures.