93 replies to this topic

[AgeVivo]

the tumors grew but the mice don't seems to suffer from it, no death
cage 1: 3 mice, the tumour is now ~1.4 cm
cage 6: 3 mice, the gray one was already big and is becoming a big bigger, and the black and white one was slightly frail and is slightly
cage 2 : 2 mice, actually no tumor, and healthy
cage 8: 5 mice - the tumor of the neck grew fast and is now ~1.6cm

[AgeVivo]

I didn't write lately but here are a few changes:

 

As a reminder, here was the state as of August 11:

"cage 1: 3 mice, the tumour is now ~1.4 cm

cage 6: 3 mice, the gray one was already big and is becoming a big bigger, and the black and white one was slightly frail and is slightly

cage 2 : 2 mice, actually no tumor, and healthy

cage 8: 5 mice - the tumor of the neck grew fast and is now ~1.6cm"

 

On August 14 I provided the mice with tumors to a friend who is developping anti-cancer therapies, along with 4 mice without visible tumors.
To know how to house them, and for the sake of testing the anti-cancer therapies and as we are reaching the end of the experiement, I decided to open the label with my son: cage 1 and 8 actually are under treatment and cage 2 and 6 are under water only. I prefer not to derive any conclusion for now (like mice with visible tumors are the ones with treatment): I will make the statistics later. So I remain partly blind.

 

So I provided him with cage 8 after having replaced one of the mice (the black mouse with reduced ears) with the mouse from cage 1 with a visible tumor

 

So on the side of my friend, for the anti-cancer potential therapies, we cage 8, with the 2 mice with a visible tumor and 3 mice without. As of today (September first), the ones with a visible tumor still look OK (despite the tumors), one or two (?) of the 3 mice died (I am waiting for pictures and details) and the 2 other ones are OK.

 

and on my side, we have cage 1, 6, 2:

cage 1: one black mouse died that was in cage 8 at the beginning of August died, the 2 other ones look fine
cage 2: the two mice are alive and look fine, I am adding the survivor of cage 6

cage 6: two mice died (the black and white and the white and beige), I am moving the remaining gray, large one mouse to cage 2

 

 

[maxwatt]

Looking at the study referenced in the introduction to this topic, which found life extension in men who had suffered a heart attack who took Viagra versus those heart attack sufferers who didn't, It occurred to me the benefit was due to Viagra relaxing blood vessels, thus lowering blood pressure.  Viagra was originally developed as a blood pressure medication, and such drugs are routinely prescribed for the elderly, especially  those who have had a heart attack.

 

Mice typically die of cancer, humans not as much, but death by cardiovascular event is a leading cause of death in humans.  I am interested in the results of this study in mice, to see if we can infer anything about the mechanisms of action if significant difference is found with the control group.

[AgeVivo]

Looking at the study referenced in the introduction to this topic, which found life extension in men who had suffered a heart attack who took Viagra versus those heart attack sufferers who didn't, It occurred to me the benefit was due to Viagra relaxing blood vessels, thus lowering blood pressure.  Viagra was originally developed as a blood pressure medication, and such drugs are routinely prescribed for the elderly, especially  those who have had a heart attack.

 

Mice typically die of cancer, humans not as much, but death by cardiovascular event is a leading cause of death in humans.  I am interested in the results of this study in mice, to see if we can infer anything about the mechanisms of action if significant difference is found with the control group.

Hi Maxmatt,

I had not posted since September because my computer crashed and the password recovery was not sending me anything. Just today I found my password in an old computer (I had an important deadline this last Friday and did not search for it before).
 

• I was planning to do a viagra mouse lifespan study and just before starting, when the mice were about 16 month old, I discovered that the Pfizer files for viagra FDA approval had been released and Pfizer had done lifespan studies with different doses of sildenafil in mice and in rats, together with necropsies (causes of death). The results are exactly like you suggest: longer lives in rats (esp males) with small doses (as would be expected in people actually), but no effect it seems on cancer, just on the cardiovascular system; less important effect in mice (who die much more from cancers compared to us), and lower lifespans at high doses
• I instead tried chlorogenic acid (something found in plums and good for the liver). At the dose used, in female mice, it seemed to lower lifespan
• For the last 3 mice I tried different things. And... one of them worked! PCC1, on a mouse that had had a stroke, which had been stabilized. in about two days the effect was spectacular. the improvement continued over 2 weeks. I don't know if it would apply for other mice but at least for some type of stroke it seems a wonder drug. Going to post items later today